Pushpa Patel

MSc by Research in Molecular Pharmacology, Coventry University, 2007

BSc (Hons) Biological Sciences, Coventry University, 2005

Before starting her PhD Pushpa worked in multitude of disciplines in the College of Medical and Dental Sciences at the University of Birmingham. Pushpa worked with Prof Mark Cooper and Prof Wiebke Arlt in the centre for endocrinology, diabetes and metabolism. She spent two years working with Prof Mark Drayson at the University of Birmingham `spin out’ company Serascience (now Abingdon Health). She worked with Prof Paulus Kirchhof in the Translational Research on Heart Failure and Arrhythmias group. In 2016 Pushpa joined the Birmingham Platelet group working with Dr Alexandra Mazharian on megakaryocyte development and platelet production.

Pushpa’s research focuses on the effect of the PEMFC nanocatalyst on human health. Nanomaterials such as the PEMFC nanocatalyst may gain access to the bloodstream via inhalation and can cause excessive activation and aggregation of platelets. The aim of the project will be to synthesise nanoparticles with different physiochemical properties, such as particle size and surface chemistry and evaluate their ability to induce activation of human platelets in vitro both in solution and on surfaces.

Outside of the lab Pushpa enjoys a range of activities including baking, running and travelling.   

Smith CW, Raslan Z, Parfitt L, Patel P, Khan AO, Senis YA, Mazharian A. TREM-like transcript 1: a more sensitive marker of platelet activation than P-selectin in humans and mice. Blood Advances 2018 August 28;2(16):2072-2078

Smith CW, Thomas SG, Raslan Z, Patel P, Byrne M, Lordkipanidzé M, Bem D, Meyaard L, Senis YA, Watson SP, Mazharian A. Mice Lacking the Inhibitory Collagen Receptor LAIR-1 Exhibit a Mild Thrombocytosis and Hyperactive Platelets. Arteriosclerosis, Thrombosis and Vascular Biology. May 2017^.37^.823-835

Holmes AP, Yu TY, Tull S, Patel P, Syeda F, Kuhlmann SM, O’Brien SM, Brain KL, Pavlovic D, Brown NA, Fabritz L, Kirchhof P. A Regional Reduction in Ito and IKACh in the Murine Posterior Left Atrial Myocardium Is Associated with Action Potential Prolongation and Increased Ectopic Activity. PLoS One. 2016 May 5;11(5):e0154077

Patel P, Hardy R, SumathiVP, BartleG, KindblomLG, GrimerR, BujalskaI, StewartPM, Rabbitt E, GittoesN, CooperMS. Expression of 11ß-Hydroxysteroid Dehydrogenase Enzymes in Human Osteosarcoma: Potential role in pathogenesis and as targets for treatments. Endocrine Related Cancer. 2012 Jul 22;19(4):589-98

Idkowiak J, Randell T, Dhir V, Patel P, Shackleton C, Krone N & Arlt W. A Missense Mutation in the Human Cytochrome b5 Gene causes 46,XY Disorder of Sex Development due to True Isolated 17,20 Lyase Deficiency. Journal of Clinical Endocrinology and Metabolism, March 2012, 97(3)

Patel P, Vatish M, Heptinstall J, Wang R, Carson RJ. The endogenous production of hydrogen sulphide in intrauterine tissues. Reproductive Biology Endocrinology. 2009 Feb 6;7:10.