GAD antibody on primate pancreas (Islet cell antibody has similar distribution). The target antigens are GAD 67 and GAD 65 which are associated with Stiff-man syndrome and insulin dependent diabetes mellitus respectively.
Low magnification: GAD staining the granular layer in the primate cerebellum. In contrast to amphiphysin there is a lack of staining in the molecular layer.
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Neurological syndrome: Stiff person’s syndrome or diffuse hypertonia. GAD has also been reported in cerebellar ataxia, epilepsy and myoclonus.
Tumour associated: Breast, colon, small cell lung carcinoma