Amphiphysin In 'Paraneoplastic Neurological Antibodies' IntroductionHu (ANNA1)Ri (ANNA2)Yo (PCA-1)AmphiphysinCV2 (CRMP5)Ma antibodyTr (PCA-Tr)Glutamic acid decarboxylase (GAD)Myelin associated glycoprotein (MAG)Skeletal muscle antibody Back to 'Neuroimmunology' Amphiphysin Amphiphysin (128 kDa dimeric, synaptic protein) is found in cerebellar presynaptic nerve terminals. The cell processes in the molecular are stained more intensely than the nerve terminals in the granular layer. The pattern in the granular layer resembles that of GAD. Amphiphysin Amphiphysin can also coexist with Hu, CV2 or PCA-2. Clinical conditions: Stiff person’s syndrome (5%), paraneoplastic encephalomyelitis. Associated tumours: Most common malignancies are small cell lung carcinoma and breast cancer