Substantial Amendment 08 Back to 'For participating sites' SA08 MHRA Cover Letter dated 08-Feb-2017 (invalidated) [pdf] SA08 MHRA Cover Letter dated 23-Mar-2017 (resubmission) [pdf] SA08 MHRA Acknowledgement of Amendment dated 28-Mar-2017 [pdf] SA08 MHRA Notice of Acceptance of Amendment dated 27-Apr-2017 [pdf] Arm A: AZD4547 Investigator’s Brochure edition 10 dated 27-Jul-2015 [pdf] Arm B: Vistusertib Investigator’s Brochure edition 6 dated 31-Mar-2016 [pdf] Arm C: Palbociclib Investigator’s Brochure dated Dec-2015 [pdf] Arm E: Selumetinib Investigator’s Brochure edition 16 dated 06-Jan-2016 [pdf] Arm E: Docetaxel Summary of Product Characteristics dated 29-May-2015 [pdf] Arm F: AZD5363 Investigator’s Brochure edition 7 dated 08-Dec-2015 [pdf] Arm G: Osimertinib Investigator’s Brochure edition 6 dated 26-Jan-2016 [pdf] Arm NA Cohort NA1: Durvalumab Investigator’s Brochure edition 9 dated 22-Jan-2016 [pdf]