Substantial Amendment 15 Back to 'For participating sites' All documents are pdf unless otherwise specified and require username and password login to access. SA15 MHRA Acknowledgement of Amendment dated 24-Oct-2018 [pdf 44 KB] SA15 MHRA Notice of Acceptance of Amendment dated 23-Nov-2018 [pdf 47 KB] SA15 HRA Approval of the Amendment dated 28-Nov-2018 [pdf 17 KB]