Amendments Back to 'TIER Trial' Substantial Amendments SA1 [.zip] - Site addition SA2 [.zip] - Site addition SA3 [.zip] - Site addition SA4 - MHRA Approval [.pdf] Ethics Approval [.pdf] Documents [.zip] Amendment form [.pdf] MHRA products form [.pdf] Ethics cover letter [.pdf] MHRA cover letter [.pdf] SA5 [.zip] - Site addition SA6 [.zip] MHRA Approval [.pdf] Ethics Approval [.pdf] Amendment form [.pdf] Ethics cover letter [.pdf] MHRA cover letter [.pdf] Documents Protocol version 3.0 [.pdf] HRA approval documents [.zip] HRA Approval letter [.pdf] Schedule of Events [.pdf] Statment of Activities [.pdf] SA10 - HRA approval letter [.pdf] REC approval letter [.pdf] MHRA approval letter [.pdf] Amendment form [.pdf] Non-Substantial Amendments NS2 Notification form [.pdf] Acknowledgement [.pdf] NS3 Notification form [.pdf] Acknowledgement [.pdf] NS4 Notification form [.pdf] Acknowledgment [.pdf]