MAJIC

MAJIC: A RandoMised study of best Available therapy versus JAK Inhibition in patients with high risk Polycythaemia Vera or Essential Thrombocythaemia who are resistant or intolerant to HydroxyCarbamide

Change of Staff

If there is a change of staff working on the trial please print off and complete the relevant registration form below. Please also ensure that the Signature and Delegation Log is updated. 

Trial Documents

Links to the current protocol, Patient Information Sheet, Informed Consent Form are provided below. If there has been a recent amendment to the trial please ensure you have R&D approval before using these documents.

Other documents (e.g. Amendments, Case Report Form, Serious Adverse Event Form, Guidelines, GP Letter, Release of Medical Information Form etc) can be found by clicking on the other menu items below. If you cannot find what you are looking for please contact the MAJIC Trial Office.

Protocol

Patient Documents

Version Control Lists

The version numbers and dates of all documents used for the trial are captured on a Version Control List. Links to the Version Control Lists used in this trial are below in reverse date order.

Amendments

Below is a link to a document which lists all of the substantial protocol amendments which have been made for this trial. The folders below contain the relevant amended documentation and approval letters. Please ensure that you have R&D approval (if applicable) before using the latest versions of these documents.

 Guidelines

Other Trial Documents

Case Report Form

Case Report Forms

Pharmacy

Pharmacy Documents

Pharmacy Version Control Documents

Publications

Harrison, C ; Mead, A; Panchal, A; Fox, S; Yap, C; Houlton, A; Aliman, S; Wood, M;  Chen, F; Coppell, J; Panoskaltsis, N; Scherber, R; Geyer, H; Dueck, A; Mesa, R;  McMullin, M. "Ruxolitinib Compared with Best Available Therapy for Essential Thrombocythemia PatientsResistant or Intolerant to Hydroxycarbamide in MAJIC - An Investigator-Led Randomised Trial." European Hematology Association 2016

Harrison, C; Mead, A; Fox, S; Bell, H; Alimam, S; Green, A; Wood, M; Ewing, J; Chen, F; Yap, C; Ahmed, I; Coppell, J; Knapper, S; McMullin, M. "Feasibility of recruitment of hydroxyurea-resistant or intolerant Essential Thombocythaemia and Polycythaemia Vera patients into the MAJIC study." British Society of Haematology 2015

Scherber, R; Fox, S, Kosiorek, H, Shah, M; Abdi-Moradi, S; Mead, A; Bell, H; Dueck, A; Aliman, S; Green, A; Wood, M; Ewing, J; Chen, F; Coppell, J; Knapper, S; McMullin, M; Geyer, H; Mesa, R; Harrison, C. "Baseline Quality of Life and Symptom Burden Characteristics of Patients Intolerant to Hydroxyurea: Preliminary results from the MAJIC Trial." British Society of Haematology 2015

Harrison, C; Mead, A; Fox, S; Bell, H; Alimam, S; Green, A; Wood, M; Ewing, J; Chen, F; Yap, C; Ahmed, I; Coppell, J; Knapper, S; McMullin, M. "Feasibility of recruitment of hydroxyurea-resistant or intolerant Essential Thombocythaemia and Polycythaemia Vera patients into the MAJIC study." NCRI Cancer Conference 2015

Scherber, R; Fox, S, Kosiorek, H, Shah, M; Abdi-Moradi, S; Mead, A; Bell, H; Dueck, A; Aliman, S; Green, A; Wood, M; Ewing, J; Chen, F; Coppell, J; Knapper, S; McMullin, M; Geyer, H; Mesa, R; Harrison, C. "Baseline Quality of Life and Symptom Burden Characteristics of Patients Intolerant to Hydroxyurea: Preliminary results from the MAJIC Trial." NCRI Cancer Conference 2015

News and Events

No current news or upcoming events

Newletters

Contact Details

Chief Investigator
Name: Professor Claire Harrison
Addresss:
Guy’s Hospital
Great Maze Pond
London, SE1 9RT

Tel:      +44 (0)121 415 9181
Fax:     +44 (0)121 414 6061
Email: majic@trials.bham.ac.uk

MAJIC Trial Office
Trial Coordinator:       Sonia Fox                            
Trial Administrator:       Samuel Bicknell                                
Trial Monitor:       Poonam Patel/Semsem Abdulle                     
Trial Management Team Leader:       Shamyla Siddique
Trial Statistician:       Anesh Panchal               

Cancer Research UK Clinical Trials Unit (CRCTU)
Department of Cancer and Genomic Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT

Enquiries
Telephone: +44 (0)121 415 9181
Fax:              +44 (0)121 414 6061
Email:        majic@trials.bham.ac.uk

Trial Entry
Telephone: +44 (0)800 371 969              (9.00 am till 5.00 pm Monday to Friday)

Serious Adverse Event Reporting
Fax: +44  (0)121 414 6061   Or   +44 (0)121 414 3700

Sponsor: The University of Birmingham