Programme
Leonard Deacon Lecture Theatre and Wolfson Common Room
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9:00
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Welcome
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Ferenc Mueller
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Chair: Conny Bonifer
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09:10
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Short talk (12 min +3)
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Ben Edginton-White
A genome-wide relay of signalling-responsive enhancers drives hematopoietic specification
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09:25
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Short talk (12 min +3)
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Alice Ormrod
Investigating how MRE11 lysine methylation regulates DNA metabolism
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09:40
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Short talk (12 min +3)
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Megan Burley
Deregulation of CTCF-YY1-dependent oncogene transcription regulation in HPV-driven disease
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09:55
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Short talk (12 min +3)
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David McQuarrie
ELAV forms a saturable complex on extended RNA, but can nucleate requiring multiple spaced U-rich motifs
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10:10
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Short talk (12 min +3)
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Claire Palles
Germline MBD4-deficiency causes a multi-tumor predisposition syndrome
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10:25
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Refreshments
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Tea/Coffee Water
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Chair: Matthias Soller
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10:55
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Short talk (12 min +3)
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Hannah Dixon
UPF1 is required for productive pre-mRNA splicing of ribosomal protein genes
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11:10
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Short talk (12 min +3)
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George Ronson
The basis of the synthetic lethal relationship between BRCA gene deficiency, 53BP1 deficiency and DNA Polymerase theta loss.
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11:25
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Short talk (12 min +3)
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Csilla Varnai
3D genome organisation in spermatozoa
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11:40
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Short talk (12 min +3)
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Rachel Bayley
MYBL2 is required for maintaining pluripotency and DNA repair in triple negative breast cancer stem cells
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11:55
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Short talk (12 min +3)
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Rui Monteiro
Lineage skewing and genome instability underlie marrow failure in a zebrafish model of GATA2 deficiency
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12:10
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Lunch and posters. Poster Panel Judges:
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Platters served
Tea/Coffee Water
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Chair: Rui Monteiro
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13:50
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Short talk (12 min +3)
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Matthew Gillespie
Investigating the Role of PRMT5 in the DNA Damage Response of Breast Cancer Stem Cells
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14:05
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Short talk (12 min +3)
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Assunta Adamo
Definition and interrogation of the gene regulatory network of CEBPA double-mutated Acute Myeloid Leukaemia
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14:20
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Short talk (12 min +3)
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Anoop Singh Chauhan
Isomerization dependent SUMOylation of RNF168 restrains its chromatin accumulation
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14:35
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Short talk (12 min +3)
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Paul Badenhorst
Combinatorial histone modifications direct ATP-dependent chromatin remodeling by NURF to promoter proximal nucleosomes.
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14:50
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Refreshments
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Tea/Coffee Water
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Clare Davies
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15:10
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Short talk (12 min +3
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Ada Jimenez-Gonzalez
Intergenerational effects of paternal starvation manifests in variation in metabolic gene expression in zebrafish development.
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15:25
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Short talk (12 min +3
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Shaun Scaramuzza
The ubiquitin ligase TRAIP plays an essential role during S-phase of unperturbed cell cycles for the resolution of DNA replication – transcription conflicts
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15:40
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Keynote Speaker (30 mins +10)
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Chair and introduction: Ferenc Mueller Kristian Helin, ICR, London
Novel Targets for the Treatment of Acute Myeloid Leukaemia
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16:20
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Prizes, thanks and close
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Ferenc and members of the executive
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16:30-
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Wine reception (donations accepted) and bring in share: Venue to be determined
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The Best of International BCGB Grub, Bring and Share!
To see what others are bringing (and to give a two-word description of your contribution) go to:https://doodle.com/meeting/participate/id/bmZ1XE9d
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Talks
A genome-wide relay of signalling-responsive enhancers drives hematopoietic specification
Edginton-White, B.1+, Maytum, A1+; Kellaway, S.G.1, Goode, D.K.2, Keane, P.1, Pagnuco, I.3,1, Assi, S.A.1, Ames, L.1, Clarke, M1, Cockerill, P.N., Göttgens, B.2, Cazier, J.B.1,3, and Bonifer, C1.
+Equal contribution
Investigating how MRE11 lysine methylation regulates DNA metabolism
Alice Ormrod, Amalia Goula, Shabana Begum and Martin Higgs
Deregulation of CTCF-YY1-dependent oncogene transcription regulation in HPV-driven disease
Megan Burley
ELAV forms a saturable complex on extended RNA, but can nucleate requiring multiple spaced U-rich motifs
David McQuarrie and Matthias Soller
School of Biosciences, University of Birmingham, Birmingham, UK, B15 2TT
Germline MBD4-deficiency causes a multi-tumor predisposition syndrome
Claire Palles1,*, Hannah D. West2,*, Edward Chew3,*, Sara Galavotti1,*, Christoffer Flensburg3,*, Judith E. Grolleman4,*, Erik A.M. Jansen4, Helen Curley1, Laura Chegwidden1, Edward H. Arbe-Barnes5, Nicola Lander2, Rebecca Truscott2, Judith Pagan6, Ashish Bajel7, Kitty Sherwood8, Lynn Martin1, Huw Thomas9, Demetra Georgiou10, Florentia Fostira11, Yael Goldberg12,13, David J. Adams14, Simone A.M. van der Biezen4, Michael Christie3,15, Mark Clendenning15,16, Laura E. Thomas17, Constantinos Deltas18, Aleksandar J. Dimovski19, Dagmara Dymerska20, Jan Lubinski20, Khalid Mahmood15,16, Rachel S. van der Post21, Mathijs Sanders22, Jürgen Weitz23, Jenny C. Taylor24, Clare Turnbull25, Lilian Vreede4, Tom van Wezel26, Celina Whalley1, Claudia Arnedo-Pac27, Gulio Caravagna25, William Cross28, Daniel Chubb25, Anna Frangou5, Andreas J. Gruber29, Ben Kinnersley25, Boris Noyvert1, David Church5, Trevor Graham30, Richard Houlston25, Nuria Lopez-Bigas27, Andrea Sottoriva28, David Wedge29, Genomics England Research Consortiuma, The CORGI Consortiumb, WGS500 Consortiumc, Mark A. Jenkins16,31, Roland P. Kuiper4,32, Andrew W. Roberts3,6,16,33, Jeremy P. Cheadle2, Marjolijn J.L. Ligtenberg4,21, Nicoline Hoogerbrugge4, Viktor H. Koelzer34, Andres Dacal Rivas35, Ingrid M. Winship36,37, Clara Ruiz Ponte38, Daniel D. Buchanan15,16,36, Derek Power39, Andrew Green40, Ian P.M. Tomlinson8,#,$, Julian R. Sampson2,#,$, Ian J. Majewski3,31,#, Richarda M. de Voer4,#
UPF1 is required for productive pre-mRNA splicing of ribosomal protein genes
Hannah L. Dixon1, Anand K. Singh1,2, Matthew Wright1, Saverio Brogna1.
School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK Interdisciplinary School of Life Sciences, Banaras Hindu University, Varanasi, 221005, India
The basis of the synthetic lethal relationship between BRCA gene deficiency, 53BP1 deficiency and DNA Polymerase theta loss.
George Ronson, Katarzyna Starowicz, Elizabeth Anthony, Lucy Clarke, Alexander J. Garvin, Andrew D Beggs1,2, Celina M Whalley2, Matthew Edmonds1,, James Beesley1 and Joanna R Morris
1: Birmingham Centre for Genome Biology and Institute of Cancer and Genomic Sciences, College of al and Dental Schools, University of Birmingham, B15 2TT, UK.
2. Genomics Birmingham, College of Medical and Dental Schools, University of Birmingham, B15 2TT, UK.
3D genome organisation in spermatozoa
Csilla Várnai*1, Gregor Jessberger*2, Roman R Stocsits2, Wen Tang2, Georg Stary2, Jan-Michael Peters2
1: Centre for Computational Biology, University of Birmingham, Birmingham, UK Institute of Cancer and Genomic Sciences, University of Birmingham, UK
2: Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria
MYBL2 is required for maintaining pluripotency and DNA repair in triple negative breast cancer stem cells
Rachel Bayley, Anna Munsey, Amber Stiby, Bohdana-Myroslava Briantseva, Marco Saponaro, Clare Davies, Paloma Garcia
Lineage skewing and genome instability underlie marrow failure in a zebrafish model of GATA2 deficiency
Christopher B. Mahony1,2, Pavle Vrljicak4, Boris Noyvert3, Chrystala Constantinidou4, Lucy Copper1,2,3, Sofia Browne1,2, Yi Pan3, Claire Palles1,2,3 ,Sascha Ott4, Martin R. Higgs1,2,3, Rui Monteiro1,2,3,
1 Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham (UK)
2 Birmingham Centre of Genome Biology, University of Birmingham, UK
3 Cancer Research UK Birmingham Centre and Centre for Computational Biology, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, UK
4 Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK
Investigating the Role of PRMT5 in the DNA Damage Response of Breast Cancer Stem Cells
Matthew Gillespie, Debashish Sahay, Kelly Chiang, Paloma Garcia, Clare Davies
Definition and interrogation of the gene regulatory network of CEBPA double-mutated Acute Myeloid Leukaemia
Assunta Adamo1, Paulynn Chin1, Peter Keane1, Salam A. Assi1, Sandeep Potluri1, Sophie G. Kellaway1, Daniel Coleman1, Anetta Ptasinska1, H. Ruud Delwel2, Peter N. Cockerill1 and Constanze Bonifer1
1Institute of Cancer and Genomic Sciences, School of Medicine and Dentistry, University of Birmingham, Birmingham, UK
2Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands
Isomerization dependent SUMOylation of RNF168 restrains its chromatin accumulation
Anoop Singh Chauhan1, Matt MacKintosh1,2 Alexander James Garvin1, Mohammed Jamshad1, Aneika Leney2, Joanna R. Morris1 Birmingham Centre for Genome Biology and Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, B15 2TT, UK.
School of Biosciences, University of Birmingham, B15 2TT, UK.
Combinatorial histone modifications direct ATP-dependent chromatin remodeling by NURF to promoter proximal nucleosomes.
So Yeon Kwon1, Boyun Jang1, Valentina Grisan1, Michelle AC Reed1, Hyeim Jung1, Ye Eun Lee1, Robyn Halston1, Giovanni Bottegoni2, Ulrich Gunther3,4, Carl Wu5, and Paul Badenhorst1
1 Institute of Cancer and Genomic Sciences, University of Birmingham, Edgbaston, B15 2TT, United Kingdom
2 Università degli Studi di Urbino Carlo Bo, Via Aurelio Saffi, 2, 61029 Urbino PU, Italy
3 Wellcome Trust Biomolecular NMR facility, University of Birmingham, Edgbaston, B15 2TT
Intergenerational effects of paternal starvation manifests in variation in metabolic gene expression in zebrafish development.
Ada Jimenez-Gonzalez1, Federico Ansaloni1,3,4 Ghazal Alavioon2, Constance Nebendahl2, Remo Sanges3,4, Ferenc Müller1, Simone Immler2
1 Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Vincent Drive, Edgbaston, B15 2TT, Birmingham, UK
2 Department of Evolutionary Biology, Uppsala University, Uppsala, Sweden, School of Biological Sciences, University of East Anglia, Norwich, United Kingdom 3 Central RNA Laboratory, Istituto Italiano di Tecnologia (IIT), Genova, Italy
4 Area of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy
The ubiquitin ligase TRAIP plays an essential role during S-phase of unperturbed cell cycles for the resolution of DNA replication – transcription conflicts
Shaun Scaramuzza, Martina Muste Sadurni, Divyasree Poovathumkadavil, Toyoaki Natsume, Patricia Rojas, Masato Kanemaki, Marco Saponaro, Agnieszka Gambus
Poster Presentations
1. Understanding the roles of the RNA helicases FaL1 and Upf1 on gene expression in Schizosaccharomyces pombe
Md Nazmul Hossain, Reece P Summers, Precious O Owuamalam and Saverio Brogna*
School of Biosciences and Birmingham Centre of Genome Biology (BCGB), University of Birmingham, UK
2. A versatile vertebrate cell-free extract system to observe replication fork collisions with non-canonical DNA structures and protein-based obstacles at the ensemble and single-molecule level.
Neville S Gilhooly and Agnieszka Gambus
Institute of Cancer and Genomic Sciences, Birmingham Centre for Genome Biology, University of Birmingham, UK.
3. Phosphorylation of ubiquitin as a novel post-translational modification in the double strand break response
Abigail Farrell, Dr Agnieszka Gambus
Institute of Cancer and Genomic Sciences, University of Birmingham, UK
4. USP50 promotes replication fork progression and restart via a ubiquitin interaction and WRN-FEN1 mediation.
Hannah L. Mackay1, Helen R. Stone1 George E. Ronson1, Alexandra K. Walker1, Katarzyna Starowicz1, Alexander J. Garvin1, Alina Vaitsiankova2, Sobana Vijayendran1,3, Katherine Ellis1, Anoop Singh Chauhan1, James Beesley1, Keith W. Caldecott2, Eva Petermann1, Eric J. Brown4, Ruth M. Densham1 and Joanna R Morris1.
Birmingham Centre for Genome Biology and Institute of Cancer and Genomic Sciences, University of Birmingham. B15 2TT. UK Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9RQ, UK.
Present address: University Hospital Birmingham NHS Foundation Trust Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Birmingham. B15 2TH. UK
Abramson Family Cancer Research Institute, Perelman School of Medicine University of Pennsylvania Institute, 421 Curie Boulevard 421 Curie Boulevard PA 19104-6160. USA.
5. Investigating the role of PRMT1 mediated methylation of FXR1 in DNA repair.
Karan Sharma, Agnieszka Zielinska, James Jarrold, Mark Skehel and Clare C. Davies.
6. Modification of the SUMO activating enzyme directs SUMO isoform bias and mitotic fidelity
Alexandra K Walker1, Alexander Lanz1, Mohammed Jamshad1, Alexander J Garvin1, Peter Wotherspoon2, Benjamin F Cooper2, Joanna R. Morris1
Birmingham Centre for Genome Biology and Institute of Cancer and Genomic Sciences, College of al and Dental Schools, University of Birmingham, B15 2TT, UK.
School of Biosciences, University of Birmingham, Birmingham, B15 2TT, U.K.
7. Characterisation of PRMT5-mediated gene regulation in breast cancer
Kelly Chiang, Debashish Sahay1, Clare C Davies
Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Vincent Drive, Birmingham, B15 2TT, UK.
8. Identification of signalling-responsive cis-regulatory elements regulating blood development
Maytum, A1+; Edginton-White, B.1+*, Kellaway, S.G.1, Goode, D.K.2, Keane, P.1, Pagnuco, I.3,1, Assi, S.A.1, Ames,
L.1, Clarke, M1, Cockerill, P.N., G ttgens, B.2, Cazier, J.B.1,3, and Bonifer, C1*.
9. Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair
Maria Pilar Sanchez-Bailon1,4,6, Soo-Youn Choi1,6, Elizabeth R. Dufficy1,6, Karan Sharma1, Gavin S. McNee1, Emma Gunnell2, Kelly Chiang1, Debashish Sahay1, Sarah Maslen3, Grant S. Stewart1, J. Mark Skehel3,5, Ingrid Dreveny2 and Clare C. Davies1
- Institute of Cancer and Genomic Sciences, University of Birmingham, UK
- Biodiscovery Institute, School of Pharmacy, University of Nottingham, Nottingham, UK
- MRC Laboratory of Molecular Biology, Cambridge, UK
- Present address: Max Delbrück Center for Molecular Medicine, Berlin, Germany
- Present address: The Francis Crick Institute, London, UK.
10. Small Ubiquitin-like Modifier 4 regulates DNA double strand break repair independently of conjugation
Alexander J. Garvin, Alexander Lanz, Ruth Densham & Joanna R. Morris
Birmingham Centre for Genome Biology, Institute of Cancer and Genomic Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
11. The differential activity of TRAIP in replisome disassembly in S-phase and mitosis
Divya Poovathumkadavil and Agnieszka Gambus
Institute for Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
12. Investigation into PIN1’s interaction with various DNA damage response proteins.
Matt Mackintosh1,2, Anoop Chauhan1, Aneika Leney2, Joanna R. Morris1
Birmingham Centre for Genome Biology and Institute of Cancer and Genomic Sciences, College of al and Dental Schools, University of Birmingham, B15 2TT, UK.
School of Biosciences, University of Birmingham, B15 2TT, UK.
13. Stratifying tumour heterogeneity through imaging and transcriptomic profiling of colorectal organoids.
Paige-Louise White1, Joseph Wragg1, Yavor Hadzhiev1, Louise Tee1, Aleksandar Atanasov1, Andrew Beggs1, Ferenc Mueller1
1 Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Vincent Drive, Edgbaston, B15 2TT, Birmingham, UK
14. Leukaemic stem cells cell hijack lineage inappropriate signalling pathways to activate growth
Alice Worker1, Sophie G Kellaway1, Sandeep Potluri1, Luke Ames1, Peter Keane1, Paulynn S Chin1, Anetta Ptasinska1, Salam Assi1, Helen Blair2, Olaf Heidenreich3, Peter N Cockerill1, Constanze Bonifer1
Institute of Cancer and Genomic Sciences/Birmingham Centre for Genome Biology, University of Birmingham, B15 2TT, UK Translation and Clinical Research Institute, Newcastle University, NE1 7RU, UK
Prinses Máxima Centrum voor kinderoncologie, 3584CS Utrecht, Netherlands
15. Questioning the Nonsense: What mechanism(s) connect pre-mRNA splicing with Nonsense Mediated mRNA Decay in fission yeast?
Precious O. Owuamalam and Saverio Brogna
School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, United Kingdom
16. Protein Arginine Methyltransferase 5 interacts with LMO2 in Human T-cell Acute Lymphoblastic Leukaemia
Fatma Saleman, Sarah Binhassan, Shorog Al Omair, Doug Ward, Sylvia Miller, Vesna Stanulovic and Maarten Hoogenkamp
17. Investigating the spatiotemporal patterning of zygotic genome activation in the yolk syncytial layer of the zebrafish embryo
H.K. Qureshi1, K. T. Wozniak , F. Mueller Co-first authors, both presenting
1Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT
18. Replication associated developmental defects are caused by hypomorphic mutations in Treslin/TICRR and MTBP
Satpal Jhujh1, Anika Marko2, Paulina Prorok3, Clara Collart4, Philip J. Byrd1, Gavin Scott McNee1, Stephen RF Twigg5, Beth Woodward1, Anil N Ganesh1, John J Reynolds1, Christopher G Mathew6, Michael A Simpson6, Raimundo Freire7, A Malcolm R Taylor1, Noa Ruhrman Shahar8, Helen V Firth9, Sander Pajusalu10, Philip Zegerman4, Christina Cardoso3, Andrew O Wilkie5, Dominik Boos2, Grant S Stewart1*.
Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK. 2. Wellcome Trust/Cancer Research UK Gurdon Institute, The Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Cambridge, UK. 3. Clinical Genetics Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK 4. Cell Biology and Epigenetics, Department of Biology, Technische Universität Darmstadt, Darmstadt, Germany. 5. Centre for Medical Biotechnology, Molecular Genetics II, University Duisburg- Essen, Essen, Germany. 7. Department of Medical and Molecular Genetics, Faculty of Life Science and Medicine, King’s College London, Guy’s Hospital, London, UK. 8. Universidad de La Laguna, La Laguna, Santa Cruz de Tenerife, Spain 9. Raphael Recanati Genetics Institute, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel 10. Cambridge University Hospitals, Addenbrooke’s Hospital, Cambridge, UK 11. Department of Clinical Genetics, United Laboratories, Tartu University Hospital, Tartu, Estonia
19. RRM3-mediated multimerization is required for ELAV function and splicing fidelity of its putative target mRNAs
Thomas, C. Dix1, Irmgard, U. Haussmann2, Ulrike Brauer1*, Min Li1*, and Matthias Soller1
School of Biosciences, College of Life and Environmental Sciences, University of Birmingham
2*. Former lab member, School of Biosciences, College of Life and Environmental Sciences, University of Birmingham Department of Life Science, Faculty of Health, Education and Life Sciences, Birmingham City University
20. Investigation of small ubiquitin-related modifier E1 phosphorylation in DNA damage repair and mitosis.
Alexander Lanz1, Alexandra K Walker1, Mohammed Jamshad1, Alexander J Garvin1, Joanna R. Morris1
Birmingham Centre for Genome Biology and Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, B15 2TT, UK
21. The impact of C/EBPa c-terminal mutation on the development of haematological disorders
Yara Alyahyawi, Ruba Al Maghrabi, Paloma Garcia
22. Targeting RNase H2-deficient malignancies
Angelo Agathanggelou1†, Sael Alatawi1, Ceri Oldreive1, Nicholas Davies1, Anne-Marie Hewitt1, David Parry2, Martin Reijns2, Diana Rioz Szwed2, Andrew Jackson2, Tatjana Stankovic1.
1-ICGS, University of Birmingham; 2- MRC Institute of Genetics and Molecular Medicine The University of Edinburgh
23. Understanding the Mechanisms by which the RNA Helicase UPF1 Reduces Cellular Stress and Degeneration
Matthew Wright and Saverio Brogna
24. New insights into molecular mechanisms of T cell differentiation, memory and homeostasis.
Peter Cockerill1, Sarah Bevington1, Peter Keane1 and David Withers2
1 Institute of Cancer and Genomic Sciences
2 Institute of Immunology and Immunotherapy
25. Investigating the Role of PRMT5 in the DNA Damage Response of Breast Cancer Stem Cells
Matthew Gillespie, Debashish Sahay, Kelly Chiang, Paloma Garcia, Clare Davies
26. Runx1 priming controls synovial fibroblast pathogenicity in inflammatory arthritis
Mahony, CB, Kemble, S, Marsh, L, Turner, J and Croft, AP.
27. The effect of Danazol as a treatment for Myelodysplastic Syndromes (MDS/AML)
Ola Abdullah Alshahrani, Manoj Raghavan, Paloma García
Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham (UK)
28. A strategy to identify transcription factors which drive resistance to histone deacetylase inhibitor treatment
Mairi MacRae1, Xiaojing Yang2, Yi Xu2, Bryan Turner1 and John Halsall1
1Chromatin and Gene Regulation Group, ICGS, University of Birmingham
2Zymo Research, CA, USA
29. Mechanisms of RAS-induced replication stress
Richard D.W. Kelly and Eva Petermann
30. Characterising replisome disassembly in human cells
Rebecca M. Jones*1, Joaquin Herrero Ruiz*1,4, Shaun Scaramuzza*1, Sarmi Nath1, Marta Henklewska1,5, Toyoaki Natsume2,3,#, Francisco Romero4, Masato T. Kanemaki2,3, Agnieszka Gambus1
1: Institute of Cancer and Genomic Sciences, Birmingham Centre for Genome Biology, University of Birmingham, UK; 2: Department of Chromosome Science, National Institute of Genetics, Research Organization of Information and Systems, Mishima, Shizuoka, Japan; 3: Department of Genetics, The Graduate University for Advanced Studies (SOKENDAI), Mishima, Shizuoka, Japan; 4: Department of Microbiology, University of Seville, Seville, Spain; *: Equal contribution; 5: Department of Pharmacology and Toxicology, Wrocław University of Environmental and Life Sciences, Wrocław, Poland; #: Current affiliation; Research Center for Genome & Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.