ABBRUPT logoABBRUPT is an emergency care trial comparing two treatments for patients in ICU with new onset atrial fibrillation (NOAF) 

The aim of the ABBRUPT Trial is to find out which treatment works better.  

LATEST NEWS! ABBRUPT is now open to recruitment. Thank you to our collaborators who have worked so hard to open sites.  

Birmingham Clinical Trials Unit will be closed from 5pm Friday 20th December 2024 and will reopen Thursday 2nd January 2025. The ABBRUPT website and REDCap database will remain active during this time for routine data entry and trial randomisations. Serious Adverse Events should continue to be reported as normal during this time. Any issues please contact the ABBRUPT inbox.

Can we please take this opportunity to wish everyone a Merry Christmas and a Happy New Year!

 

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Design

ABBRUPT is a randomised controlled trial to investiagte the clinical and cost effectriveness of Amiodarone vs Beta Blockade for treating new onset atrial fibrillation.

 

Aim of the Study

The primary aim of the study is to see how well patients are recovering 90 days after being randomised into the trial.

Setting

Suitable patients will be identified in Intensive Care Units at NHS Trusts across the UK.

Target Population

Adult patients in ICU who develop new onset atrial fibrillation.

Intervention

Participants will be randomised to receive eiether amiodarone or beta blockade.

Measurement of outcomes

The objectives are:

Primary objectives

  • To assess 90 day mortality

Secondary objectives

  • To assess ICU and hospital mortality
  • To assess rates of cardiovascular events including stroke, myocardial infarction or thromboembolism up to 90 days
  • To assess the rate of established AF by the end of ICU stay/death/day 90
  • To assess the number of episodes of bradycardia
  • To assess the number of bradycardia and bradycardic arrhythmias with haemodynamic compromise requiring intervention
  • To assess the number of significant hypotension episodes requiring intervention
  • To assess heart block
  • To assess arrhythmia with haemodynamic compromise requiring intervention including DC cardioversion
  • To assess the cost-effectiveness of the interventions
  • To assess the health care resource use including ICU and hospital length of stay