Dr Cristina L Ronchi MD, PhD

Dr Cristina Ronchi

Department of Metabolism and Systems Science
Reader in Endocrine Oncology and Consultant Endocrinologist
President-Elect of ENSAT

Contact details

Address
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Cristina Ronchi is a clinician scientist with long-standing translational expertise in endocrine tumors. Her research field mostly focuses on mechanisms involved in the pathogenesis of adrenal tumours, as well as prognostic biomarkers and novel drug targets for adrenocortical cancer.  She is particularly active in research dissemination and collaborates with several world-leading groups around Europe. Clinically active as a Consultant in Endocrinology, she leads the Adrenal Tumour Service at Queen Elizabeth Hospital Birmingham. Dr Ronchi is regularly involved in teaching undergraduate and postgraduate students at the School of Medicine.

Qualifications

  • Reader in Endocrine Oncology 2021 (UoB, UK)
  • Honorary Consultant in Endocrinology 2018 (UHB NHS Trust, UK)
  • MsSc 2014 (Germany)
  • PhD in Endocrine Sciences 2008 (Italy)
  • CCT in Endocrinology & Diabetes 2005 (Italy)
  • MBChB 2000 (Italy)

Biography

Dr Ronchi studied medicine and obtained the Specialisation in Endocrinology and Metabolic Diseases at the University of Milan (Italy). From 2010 to 2017 she worked at the Division of Endocrinology at the University Hospital of Würzburg (Germany), where she also led the section “Translational Tumor Endocrinology”.

She has been a core member of the European Network for the Study of Adrenal Tumours Executive Board since 2021 and recently elected President of the ENSAT.

She has obtained several fellowships, prizes and grants as financial support for her research projects. She has published more than 110 peer-reviewed journal articles and attended more than 160 national and international conferences as presenting author or invited speaker.

Dr Ronchi is a member of four scientific societies, two editorial boards and active as peer-reviewer for journals, grants and conferences. She is member of the Editorial Board of JCEM and Endocrine Oncology.

She coordinates the Birmingham Adrenal Team and organises regular educational activities as well as public and patient involvement and engagement events.

Dr Ronchi takes part in regular didactic activities at UoB and UHB including the supervision of undergraduate students. She also mentors and supervises visiting International Clinical Fellows. 

Teaching

  • Adrenal Lecture MBChB Year 1
  • SGT MBChB Year 1 and 2 (Adrenal, Endocrine Disorders)
  • Personal Academic Tutor MBChB Year 1 and 2 since 2019
  • Leader of MBChB Year 1 research Taster Experience
  • Undergraduate supervision: BMedSc (Clinical Sciences Intercalated Degree) course

Postgraduate supervision

2013-2020 supervision of three MD Students at the University Hospital of Wuerzburg (Esther Henning graduated 2020, Valeria Laufs graduated 2020, Raimunde Liang graduated 2021)

2014-2020 Co-Supervision of two PhD Students

  • Juliane Lippert (collaboration with the Institute of Human Genetics, Würzburg, PhD finished 2021)
  • Barbara Altieri (collaboration with the University of Rome, PhD finished 2019)

Dr Ronchi is currently available for supervision of self-funded PhD students on projects related to adrenocortical tumours

Research

  • Adrenocortical tumors

-       Pathogenesis of adrenocortical tumors and adrenal Cushing Syndrome.

-       Prognostic and predictive molecular markers in adrenocortical carcinoma (ACC)

-       Molecular targets for innovative therapies for ACC.

-       Precision medicine for adrenocortical tumours.

  • Genetic studies in endocrine tumors.
  • Pituitary tumors: patho-physiology, clinic characterisation and treatment.
  • Neuroendocrinology: patho-physiology, clinic and therapy of GH excess and deficiency. Therapeutic applications of somatostatin analogs. Regulation of ghrelin secretion in physiological and pathological conditions.
  • University Hospital of Wuerzburg
  • European Network for the Study of Adrenal Tumours 

Other activities

  • Dr Ronchi is Associate Editor for the journal Endocrine Oncology (Bioscientifica) and member of the Editorial Board of the Journal of Precision Medicine
  • Dr Ronchi is elected member of the Clinical Committee of the national Society for Endocrinology.
  • Since 2021, Dr Ronchi is head of the NAPACA working group and member of the Executive Board of the European Network for the Study of Adrenal Tumours 
  • Dr Ronchi has been active in clinical activities as Consultant Endocrinologist since 2005
  • Since 2018, she is leading the Adrenal Tumour Service at QEHB and the Adrenal Multi-Disciplinary Team at UHB (Queen Elizabeth Hospital)

Publications

Recent publications

Article

Tourigny, D, Altieri, B, Secener, KA, Sbiera, S, Schauer, MP, Arampatzi, P, Herterich, S, Sauer, S, Fassnacht, M & Ronchi, C 2024, 'Cellular landscape of adrenocortical carcinoma at single-nuclei resolution', Molecular and Cellular Endocrinology, vol. 590, 112272. https://doi.org/10.1016/j.mce.2024.112272

Lippert, J, Smith, G, Appenzeller, S, Landwehr, L-S, Prete, A, Steinhauer, S, Asia, M, Urlaub, H, Elhassan, Y, Kircher, S, Arlt, W, Fassnacht, M, Altieri, B & Ronchi, C 2024, 'Circulating cell-free DNA-based biomarkers for prognostication and disease monitoring in adrenocortical carcinoma', European Journal of Endocrinology, vol. 190, no. 3, lvae022, pp. 234-247. https://doi.org/10.1093/ejendo/lvae022

Mangone, A, Favero, V, Prete, A, Elhassan, Y, Asia, M, Hardy, R, Mantovani, G, Chiodini, I & Ronchi, C 2024, 'Inflammation-based scores in a large cohort of adrenocortical carcinoma and adrenocortical adenoma: role of the hormonal secretion pattern', Journal of endocrinological investigation. https://doi.org/10.1007/s40618-024-02426-y

Parazzoli, C, Prete, A, Favero, V, Aresta, C, Pucino, V, Ayuk, J, Asia, M, Elhassan, Y, Chiodini, I & Ronchi, C 2024, 'Inflammation-based scores in patients with pheochromocytoma', Journal of Clinical Endocrinology and Metabolism. https://doi.org/10.1210/clinem/dgae284

Aggarwal, S, Prete, A, Chortis, V, Asia, M, Sutcliffe, R, Arlt, W, Ronchi, C, Karavitaki, N, Ayuk, J & Elhassan, Y 2024, 'Pheochromocytomas Most Commonly Present As Adrenal Incidentalomas: A Large Tertiary Center Experience', European Journal of Endocrinology, vol. 109, no. 1, pp. e389–e396. https://doi.org/10.1210/clinem/dgad401

Suntornlohanakul, O, Mandal, S, Saha, P, Saygili, ES, Asia, M, Arlt, W, Elhassan, Y, Prete, A & Ronchi, C 2024, 'Presentation and management of patients with adrenal masses: a large tertiary centre experience', European Journal of Endocrinology. https://doi.org/10.1093/ejendo/lvae131

Elhassan, Y, Appenzeller, S, Landwehr, L-S, Lippert, J, Popat, D, Gilligan, L, Abdi, L, Goh, E, Diaz-Cano, S, Kircher, S, Gramlich, S, Sutcliffe, RP, Thangaratinam, S, Chan, LF, Fassnacht, M, Arlt, W & Ronchi, C 2024, 'Primary Unilateral Macronodular Adrenal Hyperplasia With Concomitant Glucocorticoid And Androgen Excess And KDM1A Inactivation', European Journal of Endocrinology, pp. 334-333. https://doi.org/10.1093/ejendo/lvae106

Altieri, B, Secener, KA, Sai, S, Fischer, C, Sbiera, S, Arampatzi, P, Kircher, S, Herterich, S, Landwehr, L-S, Vitcetz, SN, Braeuning, C, Fassnacht, M, Ronchi, C & Sauer, S 2024, 'Single-nucleus and Spatial Transcriptome Reveal Adrenal Homeostasis in Normal and Tumoral Adrenal Glands', Clinical and Translational Medicine, vol. 14, no. 8, e1798. https://doi.org/10.1002/ctm2.1798

Ko, YL, Kumar, V, Lippert, J, Diaz-Cano, S, Skordilis, K, Kimpel, O, Kircher, S, Asia, M, Elhassan, Y, Altieri, B & Ronchi, C 2023, 'Coincidence of primary adrenocortical carcinoma and melanoma: three CASE reports', BMC Endocrine Disorders, vol. 23, 4. https://doi.org/10.1186/s12902-022-01253-7

Elhassan, YS, Iqbal, F, Arlt, W, Baldeweg, SE, Levy, M, Stewart, PM, Wass, J, Pavord, S, Aled rees, D & Ronchi, C 2023, 'COVID-19-related Adrenal Haemorrhage: Multicentre UK Experience and Systematic Review of the Literature', Clinical Endocrinology, vol. 98, no. 6, 766-778. https://doi.org/10.1111/cen.14881

Catalano, R, Altieri, B, Angelousi, A, Arosio, M, Bravi, F, Canu, L, Croci, G, Detomas, M, Esposito, E, Ferrante, E, Ferrero, S, Fuss, C, Kaltsas, G, Kimpel, O, Landwehr, L-S, Luconi, M, Morelli, V, Nesi, G, Nozza, E, Sbiera, S, Serban, AL, Ronchi, CL, Mantovani, G & Peverelli, E 2023, 'High filamin A expression in adrenocortical carcinomas is associated with a favourable tumor behaviour: a European multicentric study', International Journal of Molecular Sciences, vol. 24, no. 23, 16573. https://doi.org/10.3390/ijms242316573

Mangone, A, Altieri, B, Detomas, M, Prete, A, Abbas, H, Asia, M, Elhassan, Y, Mantovani, G & Ronchi, C 2023, 'Inflammation-based scores as predictors of treatment response in advanced adrenocortical carcinoma', Endocrine-related cancer, vol. 30, no. 4, e220372. https://doi.org/10.1530/ERC-22-0372

Favero, V, Prete, A, Mangone, A, Elhassan, Y, Pucino, V, Asia, M, Hardy, R, Chiodini, I & Ronchi, C 2023, 'Inflammation-based Scores In Benign Adrenocortical Tumours Are Linked To The Degree Of Cortisol Excess: a retrospective single centre study', European Journal of Endocrinology, vol. 183, lvad151, pp. 517-526. https://doi.org/10.1093/ejendo/lvad151

Abstract

Altieri, B, Tamburello, M, Sbiera, S, Holmstoen, T, Schauer, MP, Weber, J, Kircher, S, Landwehr, LS, Kimpel, O, Lippert, J, Detomas, M, Urlaub, H, Steinhauer, S, Wierman, ME, Hantel, C, Sigala, S, Ronchi, CL, Hudecek, M, Kiseljak-Vassiliades, K & Fassnacht, M 2024, '8526 The WEE1 Kinase Inhibitor Adavosertib - A Promising Therapeutic Enhancer Of Cytotoxic Therapies In Advanced Adrenocortical Carcinoma', Journal of the Endocrine Society, vol. 8, no. Supplement_1, bvae163.305, pp. A163-A163. https://doi.org/10.1210/jendso/bvae163.305

Comment/debate

Saygili, ES, Elhassan, Y & Ronchi, C 2024, 'Is predicting metastatic pheochromocytoma and paraganglioma still effective without using methoxytyramine?', The Lancet Digital Health, vol. 6, no. 3, pp. e154-e154. https://doi.org/10.1016/S2589-7500(24)00019-0

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