Recent publications
Article
Bachoo, S, Gudgeon, N, Mann, R, Stavrou, V, Bishop, EL, Kelly, A, Uribe, AH, Loeliger, J, Frick, C, Maddocks, ODK, Lavender, P, Hess, C & Dimeloe, S 2025, 'IL-7 promotes integrated glucose and amino acid sensing during homeostatic CD4+ T cell proliferation', Cell Reports, vol. 44, no. 1, 115199. https://doi.org/10.1016/j.celrep.2024.115199
Patel, K, Nath, J, Smith, T, Darius, T, Thakker, A, Dimeloe, S, Inston, N, Ready, A & Ludwig, C 2025, 'Metabolic Characterization of Deceased Donor Kidneys Undergoing Hypothermic Machine Perfusion Before Transplantation Using 13C-enriched Glucose.', Transplantation direct, vol. 11, no. 1, e1736. https://doi.org/10.1097/TXD.0000000000001736
Smith, K, Lim, Z, Vermeren, S, Miron, V, Dimeloe, S, Davidson, D, Williams, A & Gwyer Findlay, E 2025, 'Proteomic analysis reveals dysregulation of peripheral blood neutrophils in patients with Multiple Sclerosis', Clinical & Experimental Immunology. https://doi.org/10.1093/cei/uxae115
Copland, A, Mackie, GM, Scarfe, L, Jinks, E, Lecky, DAJ, Gudgeon, N, McQuade, R, Ono, M, Barthel, M, Hardt, W-D, Ohno, H, Hoevenaar, WHM, Dimeloe, S, Bending, D & Maslowski, KM 2024, 'Salmonella cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity', EMBO Molecular Medicine. https://doi.org/10.1038/s44321-024-00159-2
Stanulović, VS, Al Omair, S, Reed, MAC, Roberts, J, Potluri, S, Fulton-Ward, T, Gudgeon, N, Bishop, EL, Roels, J, Perry, TA, Sarkar, S, Pratt, G, Taghon, T, Dimeloe, S, Günther, UL, Ludwig, C & Hoogenkamp, M 2024, 'The glutamate/aspartate transporter EAAT1 is crucial for T-cell acute lymphoblastic leukemia proliferation and survival', Haematologica. https://doi.org/10.3324/haematol.2023.283471
Bishop, EL, Gudgeon, N, Fulton-Ward, T, Stavrou, V, Roberts, J, Boufersaoui, A, Tennant, DA, Hewison, M, Raza, K & Dimeloe, S 2024, 'TNF-α signals through ITK-Akt-mTOR to drive CD4+ T cell metabolic reprogramming, which is dysregulated in rheumatoid arthritis', Science signaling, vol. 17, no. 833, eadg5678. https://doi.org/10.1126/scisignal.adg5678
Jenkins, BJ, Blagih, J, Ponce-Garcia, FM, Canavan, M, Gudgeon, N, Eastham, S, Hill, D, Hanlon, MM, Ma, EH, Bishop, EL, Rees, A, Cronin, JG, Jury, EC, Dimeloe, SK, Veale, DJ, Thornton, CA, Vousden, KH, Finlay, DK, Fearon, U, Jones, GW, Sinclair, LV, Vincent, EE & Jones, N 2023, 'Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity', Cell Metabolism, vol. 35, no. 7, pp. 1132-1146.e9. https://doi.org/10.1016/j.cmet.2023.05.001
Gudgeon, N, Giles, H, Bishop, EL, Fulton-Ward, T, Escribano-Gonzalez, C, Munford, H, James-Bott, A, Foster, K, Karim, F, Jayawardana, D, Mahmood, A, Cribbs, AP, Tennant, DA, Basu, S, Pratt, G & Dimeloe, S 2023, 'Uptake of long-chain fatty acids from the bone marrow suppresses CD8+ T-cell metabolism and function in multiple myeloma', Blood Advances, vol. 7, no. 20, pp. 6035-6047. https://doi.org/10.1182/bloodadvances.2023009890
Bishop, EL, Gudgeon, NH, Mackie, GM, Chauss, D, Roberts, J, Tennant, DA, Maslowski, KM, Afzali, B, Hewison, M & Dimeloe, S 2022, '1,25-Dihydroxyvitamin D3 suppresses CD4+ T-cell effector functionality by inhibition of glycolysis', Immunology, vol. 166, no. 3, pp. 299-309. https://doi.org/10.1111/imm.13472
Matheson, LS, Petkau, G, Sáenz-Narciso, B, D'Angeli, V, McHugh, J, Newman, R, Munford, H, West, J, Chakraborty, K, Roberts, J, Łukasiak, S, Díaz-Muñoz, MD, Bell, SE, Dimeloe, S & Turner, M 2022, 'Multiomics analysis couples mRNA turnover and translational control of glutamine metabolism to the differentiation of the activated CD4+ T cell', Scientific Reports, vol. 12, no. 1, 19657. https://doi.org/10.1038/s41598-022-24132-6
Gudgeon, N, Munford, H, Bishop, EL, Hill, J, Fulton-Ward, T, Bending, D, Roberts, J, Tennant, DA & Dimeloe, S 2022, 'Succinate uptake by T cells suppresses their effector function via inhibition of mitochondrial glucose oxidation', Cell Reports, vol. 40, no. 7, 111193. https://doi.org/10.1016/j.celrep.2022.111193
Preprint
Copland, A, Mackie, G, Scarfe, L, Lecky, D, Gudgeon, N, McQuade, R, Ono, M, Barthel, M, Hardt, W-D, Ohno, H, Dimeloe, S, Bending, D & Maslowski, K 2023 'Salmonella cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity' bioRxiv. https://doi.org/10.1101/2023.01.12.523780
Review article
Fletcher, J, Bishop, E, Harrison, S, Williamson-Swift, A, Cooper, SC, Dimeloe, S, Raza, K & Hewison, M 2022, 'Autoimmune disease and interconnections with vitamin D', Endocrine Connections, vol. 11, no. 3, e210554. https://doi.org/10.1530/EC-21-0554
Pallett, LJ, Dimeloe, S, Sinclair, LV, Byrne, AJ & Schurich, A 2021, 'A glutamine 'tug-of-war': targets to manipulate glutamine metabolism for cancer immunotherapy', Immunotherapy Advances, vol. 1, no. 1, ltab010. https://doi.org/10.1093/immadv/ltab010
Bishop, EL, Gudgeon, N & Dimeloe, S 2021, 'Control of T Cell Metabolism by Cytokines and Hormones', Frontiers in immunology, vol. 12, 653605. https://doi.org/10.3389/fimmu.2021.653605
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