Dr Vasileios Chortis MD PhD

Dr Vasileios Chortis

Department of Metabolism and Systems Science
Clinical Associate Professor in Endocrinology

Contact details

Address
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr Chortis is a Clinician Scientist in Endocrinology with a special interest in Adrenal Endocrinology and Endocrine Oncology. His research uses a range of in vitro and in vivo pre-clinical models to study the pathogenesis and biology of adrenal tumours, with a focus on adrenal cancer metabolism. His primary aim is to develop more effective medical treatment strategies for patients with adrenal cancer. His clinical research applies urine steroid profiling coupled with computational analysis as a new diagnostic approach for patients with adrenal tumours.

Qualifications

  • Completion of Clinical Training (CCT) in Endocrinology, Diabetes and General Internal Medicine, UK (2020)
  • PhD in Endocrinology, University of Birmingham (2017)
  • Member of the Royal College of Physicians, UK (2011)
  • MD, National and Kapodistrian University of Athens, Greece (2008)

Other activities

Consultant in Endocrinology, Diabetes and General Internal Medicine, University Hospitals Birmingham NHS Foundation Trust.

Publications

Recent publications

Article

Majidi, F, Martino, S, Kondakci, M, Antke, C, Haase, M, Chortis, V, Arlt, W, Ronchi, C, Fassnacht, M, Laurent, C, Petit, J-M, Casasnovas, O, Habra, M, Kanji, A, Salvatori, R, Ho, ATN, Spyroglou, A, Beuschlein, F, Villa, D, Limvorapitak, W, Engelbrekt Wahlin, B, Gimm, O, Rudelius, M, Schott, M, Germing, U, Haas, R & Gattermann, N 2020, 'Clinical spectrum of primary adrenal lymphoma: results of a multicenter cohort study', European Journal of Endocrinology, vol. 183, no. 4, pp. 453–462. https://doi.org/10.1530/EJE-19-0506

Chortis, V, Bancos, I, Nijman, T, Gilligan, L, Taylor, A, Ronchi, C, O'Reilly, M, Schreiner, J, Asia, M, Riester, A, Perotti, P, Libe, R, Quinkler, M, Canu, L, Paiva, I, Bugalho, MJ, Kastelan, D, Dennedy, MC, Sherlock, M, Ambroziak, U, Vassiliadi, D, Bertherat, J, Beuschlein, F, Fassnacht, M, Deeks, J, Biehl, M & Arlt, W 2020, 'Urine steroid metabolomics as a novel tool for detection of recurrent adrenocortical carcinoma', Journal of Clinical Endocrinology and Metabolism, vol. 105, no. 3, pp. e303–e314. https://doi.org/10.1210/clinem/dgz141

ENSAT EURINE-ACT Investigators 2020, 'Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE-ACT study: a prospective test validation study', The Lancet Diabetes and Endocrinology, vol. 8, no. 9, pp. 773-781. https://doi.org/10.1016/S2213-8587(20)30218-7

Chortis, V, May, CJH, Skordilis, K, Ayuk, J, Arlt, W & Crowley, RK 2019, 'Double trouble: two cases of dual adrenal pathologies in one adrenal mass', Endocrinology, diabetes & metabolism case reports, vol. 2019, EDM180151. https://doi.org/10.1530/EDM-18-0151

Storbeck, K-H, Schiffer, L, Baranowski, E, Chortis, V, Prete, A, Barnard, L, Gilligan, L, Taylor, A, Idkowiak, J, Arlt, W & Shackleton, C 2019, 'Steroid metabolome analysis in disorders of adrenal steroid biosynthesis and metabolism', Endocrine Reviews, vol. 40, no. 6, pp. 1605-1625. https://doi.org/10.1210/er.2018-00262

Canu, L, Van Hemert, JAW, Kerstens, M, Hartman, R, Khanna, A, Kraljevic, I, Kastelan, D, Badiu, C, Ambroziak, U, Tabarin, A, Haissaguerre, M, Buitenwerf, E, Visser, A, Mannelli, M, Arlt, W, Chortis, V, Bourdeau, I, Gagnon, N, Buchy, M, Borson-Chazot, F, Deutschbein, T, Fassnacht, M, Hubalewska Dydejczyk, HA, Motyka, M, Rzepka, W, Casey, RT, Challis, B, Quinkler, M, Vroonen, L, Spyroglou, A, Beuschlein, F, Lamas, C, Young, WF, Bancos, I & Timmers, HJ 2018, 'CT characteristics of pheochromocytoma - Relevance for the evaluation of adrenal incidentaloma', Journal of Clinical Endocrinology and Metabolism. https://doi.org/10.1210/jc.2018-01532

Arlt, W & Chortis, V 2018, 'Human fetal adrenal cells retain age-related stem and endocrine-differentiation potential in culture: in vitro human fetal adrenal models', FASEB Journal.

Chortis, V, Johal, NJ, Bancos, I, Evans, M, Skordilis, K, Guest, P, Cullen, MH, Porfiri, E & Arlt, W 2018, 'Mitotane treatment in patients with metastatic testicular Leydig cell tutor associated with severe androgen excess', European Journal of Endocrinology. https://doi.org/10.1530/EJE-17-0542

Meimaridou, E, Goldsworthy, M, Chortis, V, Fragouli, E, Foster, PA, Arlt, W, Cox, R & Metherell, LA 2018, 'NNT is a key regulator of adrenal redox homeostasis and steroidogenesis in male mice', Journal of Endocrinology, vol. 236, pp. 13-28. https://doi.org/10.1530/JOE-16-0638

Chortis, V, Taylor, A, Doig, C, Walsh, M, Meimaridou, E, Jenkinson, C, Rodriguez Blanco, G, Ronchi, C, Jaffri, A, Metherell, LA, Hebenstreit, D, Dunn, W, Arlt, W & Foster, P 2018, 'Nicotinamide nucleotide transhydrogenase as a novel treatment target in adrenocortical carcinoma', Endocrinology, vol. 159, no. 8, pp. 2836–2849. https://doi.org/10.1210/en.2018-00014

Puar, T, Engels, M, van Herwaarden, A, Sweep, F, Hulsbergen-van de Kaa, C, Kamphuis-van Ulzen, K, Chortis, V, Arlt, W, Stikkelbroeck, N, Claahsen-van der Grinten, H & Hermus, A 2017, 'Bilateral testicular tumors resulting in recurrent Cushing's syndrome after bilateral adrenalectomy', Journal of Clinical Endocrinology and Metabolism, vol. 102, no. 2, pp. 339-344. https://doi.org/10.1210/jc.2016-2702

Bancos, I, Hazeldine, J, Chortis, V, Hampson, P, Taylor, AE, Lord, J & Arlt, W 2017, 'Primary adrenal insufficiency is associated with impaired natural killer cell function: a potential link to increased mortality', European Journal of Endocrinology, vol. 176, no. 4, pp. 471-480. https://doi.org/10.1530/EJE-16-0969

Arlt, W, Lang, K, Sitch, A, Dietz, AS, Rhayem, Y, Bancos, I, Feuchtinger, A, Chortis, V, Gilligan, L, Ludwig, P, Riester, A, Asbach, E, Hughes, B, O'Neil, D, Bidlingmaier, M, Tomlinson, JW, Hassan-Smith, Z, Rees, DA, Adolf, C, Hahner, S, Quinkler, M, Dekkers, T, Deinum, J, Biehl, M, Keevil, B, Shackleton, C, Deeks, J, Walch, AK, Beuschlein, F & Reincke, M 2017, 'Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism', JCI Insight, vol. 2, no. 8, e93136. https://doi.org/10.1172/jci.insight.93136

Comment/debate

Chortis, V, Sitch, AJ, Bancos, I, Prete, A, Taylor, AE, Biehl, M, Deeks, JJ & Arlt, W 2021, 'Comment on "A Modern Assessment of Cancer Risk in Adrenal Incidentalomas: Analysis of 2219 Patients" by Kahramangil B et al', Annals of surgery. https://doi.org/10.1097/SLA.0000000000004804

Bancos, I, Taylor, A, Chortis, V, Sitch, A, Lang, K, Prete, A, Gilligan, L, Biehl, M, Deeks, J, Arlt, W & ENSAT EURINE-ACT Investigators 2020, 'Urine steroid metabolomic phenotyping for the detection of adrenocortical carcinoma: still a long way to go – Author’s reply', The Lancet Diabetes and Endocrinology, vol. 8, no. 11, pp. P877-878. https://doi.org/10.1016/S2213-8587(20)30345-4

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