Highlight publications
Certo, M, Tsai, C-H, Pucino, V, Ho, P-C & Mauro, C 2020, 'Lactate modulation of immune responses in inflammatory versus tumour microenvironments', Nature Reviews Immunology. https://doi.org/10.1038/s41577-020-0406-2
Certo, M, Elkafrawy, H, Pucino, V, Cucchi, D, Cheung, KCP & Mauro, C 2020, 'Endothelial cell and T-cell crosstalk: targeting metabolism as a therapeutic approach in chronic inflammation', British Journal of Pharmacology. https://doi.org/10.1111/bph.15002
Pucino, V, Certo, M, Bulusu, V, Cucchi, D, Goldmann, K, Pontarini, E, Haas, R, Smith, J, Headland, SE, Blighe, K, Ruscica, M, Humby, F, Lewis, MJ, Kamphorst, JJ, Bombardieri, M, Pitzalis, C & Mauro, C 2019, 'Lactate buildup at the site of chronic inflammation promotes disease by inducing CD4+ T cell metabolic rewiring', Cell Metabolism, vol. 30, no. 6, pp. 1055-1074.e8. https://doi.org/10.1016/j.cmet.2019.10.004
Recent publications
Article
Griffiths, K, Grand, RJ, Horan, I, Certo, M, Keeler, RC, Mauro, C, Tseng, C-C, Greig, I, Morrell, NW, Zanda, M, Frenneaux, MP & Madhani, M 2024, 'Fluorinated perhexiline derivative attenuates vascular proliferation in pulmonary arterial hypertension smooth muscle cells', Vascular Pharmacology, vol. 156, 107399. https://doi.org/10.1016/j.vph.2024.107399
Certo, M, Niven, J, Haas, R, Rudzinska, P, Smith, J, Cucchi, D, Hombrebueno, JR & Mauro, C 2024, 'The sedoheptulose kinase CARKL controls T cell cytokine outputs and migration by promoting metabolic reprogramming', Discovery Immunology. https://doi.org/10.1093/discim/kyae016
Wijesinghe, S, Badoume, A, Nanus, D, Sharma-Oates, A, Farah, H, Certo, M, Alnajjar, FAQ, Davis, E, Mauro, C, Lindsay, MA & Jones, S 2023, 'Obesity defined molecular endotypes in the synovium of patients with osteoarthritis provides a rationale for therapeutic targeting of fibroblast subsets', Clinical and Translational Medicine, vol. 13, no. 4, e1232. https://doi.org/10.1002/ctm2.1232
Farah, H, Wijesinghe, S, Nicholson, T, Alnajjar, FAQ, Certo, M, Alghamdi, AMA, Davis, E, Young, S, Mauro, C & Jones, S 2022, 'Differential metabotypes in synovial fibroblasts and synovial fluid in hip osteoarthritis patients support inflammatory responses', International Journal of Molecular Sciences, vol. 23, no. 6, 3266. https://doi.org/10.3390/ijms23063266
Camacho-Muñoz, D, Niven, J, Kucuk, S, Cucchi, D, Certo, M, Jones, SW, Fischer, DP, Mauro, C & Nicolaou, A 2022, 'Omega-3 polyunsaturated fatty acids reverse the impact of western diets on regulatory T cell responses through averting ceramide-mediated pathways', Biochemical Pharmacology, vol. 204, 115211. https://doi.org/10.1016/j.bcp.2022.115211
Garcia, AM, Bishop, E, Li, D, Jeffery, L, Garten, A, Thakker, A, Certo, M, Mauro, C, Tennant, DA, Dimeloe, S, Evelo, CT, Coort, SL & Hewison, M 2021, 'Tolerogenic effects of 1,25-dihydroxyvitamin D on dendritic cells involve induction of fatty acid synthesis', The Journal of Steroid Biochemistry and Molecular Biology, vol. 211, 105891. https://doi.org/10.1016/j.jsbmb.2021.105891
Cucchi, D, Camacho-muñoz, D, Certo, M, Niven, J, Smith, J, Nicolaou, A & Mauro, C 2019, 'Omega-3 polyunsaturated fatty acids impinge on CD4+ T cell motility and adipose tissue distribution via direct and lipid mediator-dependent effects', Cardiovascular Research. https://doi.org/10.1093/cvr/cvz208
Maiarù, M, Leese, C, Certo, M, Echeverria-Altuna, I, Mangione, AS, Arsenault, J, Davletov, B & Hunt, SP 2018, 'Selective neuronal silencing using synthetic botulinum molecules alleviates chronic pain in mice', Science Translational Medicine, vol. 10, no. 450, eaar7384. https://doi.org/10.1126/scitranslmed.aar7384
Comment/debate
Certo, M, Niven, J & Mauro, C 2023, 'Repurposing SGLT2 inhibitors for autoimmune diseases? YES, WE MAY!', Cell Chemical Biology, vol. 30, no. 9, pp. 1009-1011. https://doi.org/10.1016/j.chembiol.2023.07.020
Review article
Certo, M, Rahimzadeh, M & Mauro, C 2024, 'Immunometabolism in atherosclerosis: a new understanding of an old disease', Trends in Biochemical Sciences. https://doi.org/10.1016/j.tibs.2024.06.003
Certo, M, Llibre, A, Lee, W & Mauro, C 2022, 'Understanding lactate sensing and signalling', Trends in Endocrinology & Metabolism, vol. 33, no. 10, pp. 722-735. https://doi.org/10.1016/j.tem.2022.07.004
Conway, J, Certo, M, Lord, JM, Mauro, C & Duggal, NA 2022, 'Understanding the role of host metabolites in the induction of immunesenescence: future strategies for keeping the ageing population healthy', British Journal of Pharmacology, vol. 179, no. 9, pp. 1808-1824. https://doi.org/10.1111/bph.15671
Certo, M, Marone, G, de Paulis, A, Mauro, C & Pucino, V 2020, 'Lactate: fueling the fire starter', Wires Systems Biology and Medicine, vol. 12, no. 3, e1474, pp. 1-15. https://doi.org/10.1002/wsbm.1474
Pucino, V, Certo, M, Varricchi, G, Marone, G, Ursini, F, Rossi, FW, de Paulis, A, Mauro, C, Raza, K & Buckley, C 2020, 'Metabolic checkpoints in rheumatoid arthritis', Frontiers in Physiology, vol. 11, 347. https://doi.org/10.3389/fphys.2020.00347
Cucchi, D, Camacho-Muñoz, D, Certo, M, Pucino, V, Nicolaou, A & Mauro, C 2019, 'Fatty acids - from energy substrates to key regulators of cell survival, proliferation and effector function', Cell Stress - The journal of the European Research Institute for Integrated Cellular Pathology, vol. 4, no. 1, pp. 9-23. https://doi.org/10.15698/cst2020.01.209
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