Dr Palak Trivedi BSc (hons), MBBS, MRCP Gastro (UK), PhD

Palak Trivedi

Department of Immunology and Immunotherapy
Associate Professor and Honorary Consultant Hepatologist
Clinical Research Director for Industry Engagement

Contact details

Address
NIHR Birmingham BRC
Centre for Liver and Gastrointestinal Research
Institute of Immunology and Immunotherapy
ITM Building, Mindelsohn Way
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr. Trivedi is a Clinician Scientist in the National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre (BRC), based at the University of Birmingham. Dr. Trivedi is a Consultant Hepatologist who has devoted his clinical and research career to studying immune-mediated and chronic cholestatic liver disease, specifically primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC).

Palak is chief investigator for the UK-PSC consortium, and was elected chair of the British Association for Study of the Liver Special Interest Group (BASL SIG) for immune-mediated liver disease in 2018.

Qualifications

  • PhD in liver Immunology, University of Birmingham, 2015
  • Member of the Royal College of Physicians, London, 2008
  • MBBS, St. George’s Hospital Medical School, London, 2005
  • BSc (hons) in Medical Genetics, St. George’s Hospital Medical School, London, 2012

Biography

Palak completed his PhD in Liver Immunology in 2015, securing a competitively awarded Wellcome Trust Clinical Research Fellowship. During this time, his work on risk stratification in PBC was ranked the highest scoring clinical abstract at the EASL International Liver Congress.

Palak went on to receive the Investigator of the Year award in 2017 for work on gut-liver immunity in PSC, was recipient of the Andy Burroughs’ prize for best Hepatology research at the British Association for Study of the Liver (BASL), and won the Elwyn Elias prize for research into PSC and liver transplantation the same year. Palak is currently a mid-career researcher at the University of Birmingham, with 50% protected research time and the remainder dedicated to clinical practice.

Palak currently leads the PBC and PSC clinical research programme, with the overarching themes of work focussing on the role of gut-liver immunity, modelling the natural history of PBC and PSC, generating real-world clinical outcome data, and risk stratification pre- and post-transplantation.

Teaching

  • Lead for the year 4 and 5 gastroenterology and hepatology MBChB programme

Postgraduate supervision

Post-doc supervision

  • Dr. Scott Davies
  • Dr. Hannah Crothers

MD/PhD supervision

  • Dr. Nadir Abbas
  • Dr. Sheeba Khan

Research

  • Exercise intervention to attenuate symptoms in cholestasis
  • Epidemiology of primary sclerosing cholangitis
  • Risk stratification in chronic cholestatic liver disease
  • Characterising the natural history of PBC and PSC
  • Gut-liver immunity in the pathogenesis of autoimmune liver disease
  • Clinical trial design in rare disease
  • Immune-therapy induced liver injury
  • Exploring stability and function of regulatory T cells in human livers to develop and deliver immunotherapy for autoimmune hepatitis

Publications

Recent publications

Article

Freer, A, Williams, FR, Durman, S, Hayden, J, Armstrong, MJ & Trivedi, PJ 2024, 'A home-based exercise programme attenuates fatigue in primary biliary cholangitis: Results from the EXCITED clinical trial', JHEP Reports, vol. 6, no. 12, 101210. https://doi.org/10.1016/j.jhepr.2024.101210

UK-PBC audit group, Abbas, N, Smith, R, Flack, S, Bains, V, Aspinall, RJ, Jones, RL, Burke, L, Thorburn, D, Heneghan, M, Yeoman, A, Leithead, J, Braniff, C, Robertson, A, Mitchell, C, Thain, C, Mitchell-Thain, R, Jones, D, Trivedi, PJ, Mells, GF & Alrubaiy, L 2024, 'Critical shortfalls in the management of PBC: Results of a UK-wide, population-based evaluation of care delivery', JHEP Reports, vol. 6, no. 1, 100931. https://doi.org/10.1016/j.jhepr.2023.100931

Global & ERN Rare-Liver PBC Study Groups, Lam, L, Soret, P-A, Lemoinne, S, Hansen, B, Hirschfield, G, Gulamhusein, A, Montano-Loza, AJ, Lytvyak, E, Parés, A, Olivas, I, Londono, M-C, Rodríguez-Tajes, S, Eaton, JE, Osman, KT, Schramm, C, Sebode, M, Lohse, AW, Dalekos, G, Gatselis, N, Nevens, F, Cazzagon, N, Zago, A, Russo, FP, Floreani, A, Abbas, N, Trivedi, P, Thorburn, D, Saffioti, F, Barkai, L, Roccarina, D, Calvaruso, V, Fichera, A, Delamarre, A, Sobenko, N, Villamil, AM, Medina-Morales, E, Bonder, A, Patwardhan, V, Rigamonti, C, Carbone, M, Invernizzi, P, Cristoferi, L, van der Meer, A, de Veer, R, Zigmond, E, Yehezkel, E, Kremer, AE, Deibel, A, Bruns, T, Große, K, Wetten, A, Dyson, JK, Jones, D, Levy, C, Tanaka, A, Dumortier, J, Pageaux, G-P, de Lédinghen, V, Carrat, F, Chazouillères, O & Corpechot, C 2024, 'Dynamics of liver stiffness measurement and clinical course of primary biliary cholangitis', Clinical Gastroenterology and Hepatology. https://doi.org/10.1016/j.cgh.2024.06.035

the OCTAVE Collaborative Group, PITCH study, and the EASL supported COVID-Hep vaccine network, Murray, SM, Pose, E, Wittner, M, Londoño, MC, Schaub, G, Cook, J, Dimitriadis, S, Meacham, G, Irwin, S, Lim, Z, Duengelhoef, P, Sterneck, M, Lohse, AW, Perez, V, Trivedi, P, Bhandal, K, Mullish, BH, Manousou, P, Provine, NM, Avitabile, E, Carroll, M, Tipton, T, Healy, S, Burra, P, Klenerman, P, Dunachie, S, Kronsteiner, B, Maciola, AK, Pasqual, G, Hernandez-Gea, V, Garcia-Pagan, JC, Lampertico, P, Iavarone, M, Gines, P, Lütgehetmann, M, Schulze zur Wiesch, J, Russo, FP, Barnes, E & Marjot, T 2024, 'Immune responses and clinical outcomes after COVID-19 vaccination in patients with liver disease and liver transplant recipients', Journal of Hepatology, vol. 80, no. 1, pp. 109-123. https://doi.org/10.1016/j.jhep.2023.10.009

Roberts, SB, Choi, WJ, Worobetz, L, Vincent, C, Flemming, JA, Cheung, A, Qumosani, K, Swain, M, Grbic, D, Ko, HH, Peltekian, KM, Abrahamyan, L, Saini, M, Tirona, K, Aziz, B, Lytvyak, E, Invernizzi, P, Ponsioen, CY, Bruns, T, Cazzagon, N, Lindor, K, Dalekos, GN, Gatselis, NK, Verhelst, X, Floreani, A, Corpechot, C, Mayo, MJ, Levy, C, Londoño, M-C, Battezzati, PM, Pares, A, Nevens, F, van der Meer, A, Kowdley, KV, Trivedi, PJ, Lleo, A, Thorburn, D, Carbone, M, Selzner, N, Gulamhusein, AF, Janssen, HLA, Montano-Loza, AJ, Mason, AL, Hirschfield, GM & Hansen, BE 2024, 'Loss of biochemical response at any time worsens outcomes in UDCA-treated patients with primary biliary cholangitis', JHEP Reports. https://doi.org/10.1016/j.jhepr.2024.101168

Quraishi, MN, Cheesbrough, J, Rimmer, P, Mullish, BH, Sharma, N, Efstathiou, E, Acharjee, A, Gkoutus, G, Patel, A, Marchesi, JR, Camuzeaux, S, Chappell, K, Valdivia-Garcia, MA, Ferguson, J, Brookes, M, Walmsley, M, Rossiter, A, van Schaik, W, McInnes, RS, Cooney, R, Trauner, M, Beggs, A, Iqbal, T & Trivedi, PJ 2024, 'Open label vancomycin in primary sclerosing cholangitis-inflammatory bowel disease: improved colonic disease activity and associations with changes in host-microbiome-metabolomic signatures', Journal of Crohn's & Colitis. https://doi.org/10.1093/ecco-jcc/jjae189

Montano-Loza, AJ, Lytvyak, E, Hirschfield, G, Hansen, BE, Ebadi, M, Berney, T, Toso, C, Magini, G, Villamil, A, Nevens, F, Van den Ende, N, Pares, A, Ruiz, P, Terrabuio, D, Trivedi, PJ, Abbas, N, Donato, MF, Yu, L, Landis, C, Dumortier, J, Dyson, JK, van der Meer, AJ, de Veer, R, Pedersen, M, Mayo, M, Manns, MP, Taubert, R, Theresa, K, Belli, LS, Mazzarelli, C, Stirnimann, G, Floreani, A, Cazzagon, N, Russo, FP, Burra, P, Zigmound, U, Houri, I, Carbone, M, Mulinacci, G, Fagiuoli, S, Pratt, DS, Bonder, A, Schiano, TD, Haydel, B, Lohse, A, Schramm, C, Rüther, D, Casu, S, Verhelst, X, Beretta-Piccoli, BT, Robles, M, Mason, AL, Corpechat, C & Global PBC Study Group 2024, 'Prognostic Scores for Ursodeoxycholic Acid-Treated Patients Predict Graft Loss and Mortality in Recurrent Primary Biliary Cholangitis after Liver Transplantation', Journal of Hepatology. https://doi.org/10.1016/j.jhep.2024.05.010

Hussain, N, Ma, C, Hirschfield, G, Walmsley, M, Hanford, P, Vesterhus, M, Kowdley, K, Bergquist, A, Ponsioen, C, Levy, C, Assis, D, Schramm, C, Bowlus, C, Trauner, M, Aiyegbusi, OL, Jairath, V & Trivedi, PJ 2024, 'Protocol for the development of a core outcome set for clinical trials in primary sclerosing cholangitis', BMJ open, vol. 14, no. 6, e080143. https://doi.org/10.1136/bmjopen-2023-080143

Trivedi, PJ, Arndtz, K, Abbas, N, Telford, A, Young, L, Banerjee, R, Eddowes, P, Jhaveri, KS & Hirschfield, GM 2024, 'Quantitative MRCP and metrics of bile duct disease over time in patients with primary sclerosing cholangitis: A prospective study', Alimentary Pharmacology & Therapeutics, pp. 1-10. https://doi.org/10.1111/apt.17944

Greenman, R, Segal-Salto, M, Barashi, N, Hay, O, Katav, A, Levi, O, Vaknin, I, Aricha, R, Aharoni, S, Snir, T, Mishalian, I, Olam, D, Amer, J, Salhab, A, Safadi, R, Maor, Y, Trivedi, P, Weston, CJ, Saffioti, F, Hall, A, Pinzani, M, Thorburn, D, Peled, A & Mor, A 2023, 'CCL24 regulates biliary inflammation and fibrosis in primary sclerosing cholangitis', JCI Insight, vol. 8, no. 12, e162270. https://doi.org/10.1172/jci.insight.162270

ESOT Guidelines Taskforce 2023, 'Liver Transplantation for Primary Sclerosing Cholangitis (PSC) With or Without Inflammatory Bowel Disease (IBD)—A European Society of Organ Transplantation (ESOT) Consensus Statement', Transplant international, vol. 36, 11729. https://doi.org/10.3389/ti.2023.11729

IAIHG and EASL DHILI Consortium 2023, 'Nomenclature, Diagnosis and Management of Drug-induced Autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report', Journal of Hepatology, vol. 79, no. 3, pp. 853-866. https://doi.org/10.1016/j.jhep.2023.04.033

Mayo, MJ, Vierling, JM, Bowlus, CL, Levy, C, Hirschfield, GM, Neff, GW, Galambos, MR, Gordon, SC, Borg, BB, Harrison, SA, Thuluvath, PJ, Goel, A, Shiffman, ML, Swain, MG, Jones, DEJ, Trivedi, P, Kremer, AE, Aspinall, RJ, Sheridan, DA, Dörffel, Y, Yang, K, Choi, YJ & McWherter, CA 2023, 'Open‐label, clinical trial extension: Two‐year safety and efficacy results of seladelpar in patients with primary biliary cholangitis', Alimentary Pharmacology & Therapeutics. https://doi.org/10.1111/apt.17755

Review article

Trivedi, PJ, Hirschfield, GM, Adams, DH & Vierling, JM 2024, 'Immunopathogenesis of Primary Biliary Cholangitis, Primary Sclerosing Cholangitis and Autoimmune Hepatitis: Themes and Concepts', Gastroenterology, vol. 166, no. 6, pp. 995-1019. https://doi.org/10.1053/j.gastro.2024.01.049

Ricciuto, A, Kamath, BM, Hirschfield, GM & Trivedi, PJ 2023, 'Primary sclerosing cholangitis and overlap features of autoimmune hepatitis: A coming of age or an age-ist problem?', Journal of Hepatology, vol. 79, no. 2, pp. 567-575. https://doi.org/10.1016/j.jhep.2023.02.030

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