Dr Richard D Horniblow (He/Him) MSci, PhD, FHEA

Dr Richard D Horniblow (He/Him)

Department of Biomedical Sciences
Associate Professor in Gastrointestinal Biomedical Science

Contact details

Telephone
+44 (0)121 415 1991
Email
r.horniblow@bham.ac.uk
View my research portal
Address
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Richard is an Associate Professor in Gastrointestinal Biomedical Science within the Department of Biomedical Sciences. His research focusses on how different dietary components contribute to the development and progression of intestinal diseases and in particular how the intestinal microbiome is implicated. Previous work has focussed on dietary iron and how this key nutrient can modulate intestinal disease. From this, he has developed novel therapies that can target toxic intestinal iron rendering it inert. Most recently he is developing new orally administered live bio-therapeutics that are able to deliver highly viable anaerobic gut bacteria to the colon that may have clinical potential in treating Inflammatory Bowel Disease (IBD). This translational work is underpinned by pioneering Faecal Microbial Transplantation (FMT) studies undertaken at the University of Birmingham. 

Richard is a fellow of the Higher Education Academy and teaches on several modules in the Biomedical Science and MBChB programmes. He is also module lead for the Biomedical Birmingham International Summer School.

Qualifications

  • Fellow of the Higher Education Academy, 2021
  • PhD in Medicinal Chemistry/Cancer, 2015
  • MSci in Chemistry with Pharmacology, Class I, University of Birmingham, 2011

Teaching

Other activities

Richard is involved in many public engagement events for Cancer Research UK, raising awareness of his research. His research is also showcased on chemBAM.com and assists in developing demonstrations suitable for use in schools with the aim of bringing university-research to students. He was previously a PhD tutor for The Brilliant Club, a charity that exists to increase the number of pupils from under-represented backgrounds progressing to highly-selective universities.

Publications

Recent publications

Article

Johnson, TN, Batchelor, HK, Goelen, J, Horniblow, RD & Dinh, J 2024, 'Combining data on the bioavailability of midazolam and physiologically‐based pharmacokinetic modeling to investigate intestinal CYP3A4 ontogeny', CPT: Pharmacometrics & Systems Pharmacology. https://doi.org/10.1002/psp4.13192

Ta, L, Corrigan, S, Tselepis, C, Iqbal, T, Ludwig, C & Horniblow, R 2024, 'Gastrointestinal-inert prebiotic micro-composites improve the growth and community diversity of mucosal-associated bacteria', Journal of Controlled Release, vol. 375, pp. 495-512. https://doi.org/10.1016/j.jconrel.2024.09.021

Ta, LP, Corrigan, S & Horniblow, R 2024, 'Novel pectin-carboxymethylcellulose-based double-layered mucin/chitosan microcomposites successfully protect the next-generation probiotic Akkermansia muciniphila through simulated gastrointestinal transit and alter microbial communities within colonic ex vivo bioreactors', International Journal of Pharmaceutics, vol. 665, 124670. https://doi.org/10.1016/j.ijpharm.2024.124670

Horniblow, RD, Pathak, P, Eshrati, M, Latunde-Dada, GO & Tselepis, C 2023, 'Intestinal iron bio-accessibility changes by Lignin and the subsequent impact on cell metabolism and intestinal microbiome communities', Food & Function, vol. 14, no. 8, 3673, pp. 3673-3685. https://doi.org/10.1039/d2fo03807b

Goelen, J, Farrell, G, McGeehan, J, Titman, CM, J W Rattray, N, Johnson, TN, Horniblow, RD & Batchelor, HK 2023, 'Quantification of drug metabolising enzymes and transporter proteins in the paediatric duodenum via LC-MS/MS proteomics using a QconCAT technique', European Journal of Pharmaceutics and Biopharmaceutics, vol. 191, pp. 68-77. https://doi.org/10.1016/j.ejpb.2023.08.011

Horniblow, RD, Pathak, P, Balacco, DL, Acharjee, A, Lles, E, Gkoutos, G, Beggs, AD & Tselepis, C 2022, 'Iron-mediated epigenetic activation of NRF2 targets', Journal of Nutritional Biochemistry, vol. 101, 108929. https://doi.org/10.1016/j.jnutbio.2021.108929

Goelen, J, Alexander, B, Wijesinghe, HE, Evans, E, Pawar, G, Horniblow, R & Batchelor, H 2021, 'Quantification of fluid volume and distribution in the paediatric colon via magnetic resonance imaging', Pharmaceutics, vol. 13, no. 10, 1729. https://doi.org/10.3390/pharmaceutics13101729

Quraishi, MN, Acharjee, A, Beggs, AD, Horniblow, R, Tselepis, C, Gkoutos, G, Ghosh, S, Rossiter, A, Loman, N, van Schaik, W, Withers, D, Walters, JRF, Hirschfield, GM & Iqbal, TH 2020, 'A pilot integrative analysis of colonic gene expression, gut microbiota, and immune infiltration in primary sclerosing cholangitis-inflammatory bowel disease: association of disease with bile acid pathways', Journal of Crohn's & Colitis, vol. 14, no. 7, pp. 935-947. https://doi.org/10.1093/ecco-jcc/jjaa021

Horniblow, R, Mistry, P, Quraishi, MN, Beggs, A, van De Weile, T, Iqbal, T & Tselepis, C 2019, 'The safety and tolerability of a potential alginate-based iron chelator: results of a healthy participant study', Nutrients, vol. 11, no. 3, 674. https://doi.org/10.3390/nu11030674, https://doi.org/10.3390/nu11030674

Phillips, E, Horniblow, RD, Poole, V, Bedford, M, Ward, DG, Kirkham, AJ, Tomlinson, J, Iqbal, TH & Tselepis, C 2018, 'A potential role for hepcidin in obesity-driven colorectal tumourigenesis', Oncology reports, vol. 39, no. 1, pp. 392-400. https://doi.org/10.3892/or.2017.6062

Horniblow, RD, Bedford, M, Hollingworth, R, Evans, S, Sutton, E, Lal, N, Beggs, A, Iqbal, TH & Tselepis, C 2017, 'B-RAF mutations are associated with increased iron regulatory protein-2 expression in colorectal tumourigenesis', Cancer Science. https://doi.org/10.1111/cas.13234

Hollingworth, R, Horniblow, R, Forrest, C, Stewart, G & Grand, R 2017, 'Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus', Journal of virology, vol. 91, e00930-17. https://doi.org/10.1128/JVI.00930-17

Horniblow, RD, Henesy, D, Iqbal, TH & Tselepis, C 2016, 'Modulation of iron transport, metabolism and reactive oxygen status by quercetin-iron complexes in vitro', Molecular Nutrition & Food Research. https://doi.org/10.1002/mnfr.201600692

Jian, N, Dowle, M, Horniblow, RD, Tselepis, C & Palmer, RE 2016, 'Morphology of the ferritin iron core by aberration corrected scanning transmission electron microscopy', Nanotechnology, vol. 27, no. 46, 46LT02. https://doi.org/10.1088/0957-4484/27/46/46LT02

Review article

Rees, NP, Shaheen, W, Quince, C, Tselepis, C, Horniblow, RD, Sharma, N, Beggs, AD, Iqbal, TH & Quraishi, MN 2022, 'Systematic review of donor and recipient predictive biomarkers of response to faecal microbiota transplantation in patients with ulcerative colitis', EBioMedicine, vol. 81, 104088. https://doi.org/10.1016/j.ebiom.2022.104088

View all publications in research portal