Recent publications
Article
Slater, A, Khattak, S & Thomas, MR 2024, 'GPVI inhibition: Advancing antithrombotic therapy in cardiovascular disease', European heart journal. Cardiovascular pharmacotherapy. https://doi.org/10.1093/ehjcvp/pvae018
Smith, C, Campos, J, Brown, H, Ivanova, V-S, Harbi, M, Garcia Quintanilla, L, Jossi, S, Perez-Toledo, M, Rookes, K, Brill, A, Theodore, L, Owens, T, LaStant, J, Foulke, MC, Mukai, S, Francesco, M, Storek, M, Hicks, A, Langrish, C, Nunn, PA, Cunningham, A, Chauhan, A, Thomas, MR, Watson, S & Nicolson, P 2024, 'Selective Btk inhibition by PRN1008/PRN473 blocks human CLEC-2 & PRN473 reduces venous thrombosis formation in mice', Blood Advances. https://doi.org/10.1182/bloodadvances.2024012713
Alenazy, F, Harbi, M, Kavanagh, D, Price, J, Brady, P, Hargreaves, O, Harrison, P, Slater, A, Tiwari, A, Nicolson, P, Connolly, D, Kirchhof, P, Kalia, N, Jandrot-Perrus, M, Mangin, PH, Watson, S & Thomas, MR 2023, 'Amplified inhibition of atherosclerotic plaque-induced platelet activation by glenzocimab with dual antiplatelet therapy JTH', Journal of thrombosis and haemostasis : JTH, vol. 21, no. 11, pp. 3236-3251. https://doi.org/10.1016/j.jtha.2023.07.018
Damaskinaki, F-N, Jooss, NJ, Martin, EM, Clark, JC, Thomas, MR, Poulter, NS, Emsley, J, Kellam, B, Watson, SP & Slater, A 2023, 'Characterizing the binding of glycoprotein VI with nanobody 35 reveals a novel monomeric structure of glycoprotein VI where the conformation of D1+D2 is independent of dimerization', Journal of thrombosis and haemostasis : JTH, vol. 21, no. 2, pp. 317-328. https://doi.org/10.1016/j.jtha.2022.11.002
Scott, P, Heigl, M, McCay, C, Shepperdson, P, Lima‐Walton, E, Andrikopoulou, E, Brunnhuber, K, Cornelius, G, Faulding, S, McAlister, B, Rowark, S, South, M, Thomas, MR, Whatling, J, Williams, J, Wyatt, JC & Greaves, F 2023, 'Modelling clinical narrative as computable knowledge: The NICE computable implementation guidance project', Learning Health Systems. https://doi.org/10.1002/lrh2.10394
Jooss, NJ, Smith, CW, Slater, A, Montague, SJ, Di, Y, O'shea, C, Thomas, MR, Henskens, YMC, Heemskerk, JWM, Watson, SP & Poulter, NS 2022, 'Anti-GPVI nanobody blocks collagen- and atherosclerotic plaque-induced GPVI clustering, signaling and thrombus formation', Journal of Thrombosis and Haemostasis, vol. 20, no. 11, pp. 2617-2631. https://doi.org/10.1111/jth.15836
Harbi, M, Smith, C, Alenazy, F, Nicolson, P, Tiwari, A, Watson, S & Thomas, MR 2022, 'Antithrombotic effects of fostamatinib in combination with conventional antiplatelet drugs', International Journal of Molecular Sciences, vol. 23, no. 13, 6982. https://doi.org/10.3390/ijms23136982
Bourne, J, Smith, C, Jooss, N, Di, Y, Brown, H, Montague, S, Thomas, M, Poulter, N, Rayes, J & Watson, SP 2022, 'CLEC-2 supports platelet aggregation in mouse but not human blood at arterial shear', Thrombosis and Haemostasis, vol. 122, no. 12, pp. 1988-2000. https://doi.org/10.1055/a-1896-6992
Brady, PF, Chua, W, Nehaj, F, Connolly, DL, Khashaba, A, Purmah, YJV, Ul-Qamar, MJ, Thomas, MR, Varma, C, Schnabel, RB, Zeller, T, Fabritz, L & Kirchhof, PF 2022, 'Interactions Between Atrial Fibrillation and Natriuretic Peptide in Predicting Heart Failure Hospitalization or Cardiovascular Death', Journal of the American Heart Association, vol. 11, no. 4, e022833. https://doi.org/10.1161/JAHA.121.022833
Colicchia, M, Schrottmaier, WC, Perrella, G, Reyat, JS, Begum, J, Slater, A, Price, J, Clark, JC, Zhi, Z, Simpson, M, Bourne, J, Poulter, NS, Khan, AO, Nicolson, PLR, Pugh, MR, Harrison, P, Iqbal, AJ, Rainger, GE, Watson, SP, Thomas, MR, Mutch, NJ, Assinger, A & Rayes, J 2022, 'S100A8/A9 drives the formation of procoagulant platelets through GPIbα', Blood. https://doi.org/10.1182/blood.2021014966
Smith, C, Harbi, M, Garcia Quintanilla, L, Rookes, K, Brown, H, Poulter, N, Watson, S, Nicolson, P & Thomas, MR 2022, 'The Btk inhibitor AB-95-LH34 potently inhibits atherosclerotic plaque-induced thrombus formation and platelet procoagulant activity', Journal of Thrombosis and Haemostasis. https://doi.org/10.1111/jth.15899
Cooper, NI, Altomare, I, Thomas, MR, Nicolson, P, Watson, S, Markovtsov, V, Todd, LK, Masuda, E & Bussel, JB 2021, 'Assessment of thrombotic risk during long-term treatment of immune thrombocytopenia with fostamatinib', Therapeutic Advances in Hematology, vol. 12, 20406207211010875. https://doi.org/10.1177/20406207211010875
Perrella, G, Huang, J, Provenzale, I, Swieringa, F, Heubel-Moenen, F, Farndale, RW, Roest, M, Van Der Meijden, P, Thomas, M, Ariëns, RAS, Jandrot-Perrus, M, Watson, S & Heemskerk, JWM 2021, 'Nonredundant roles of platelet glycoprotein VI and integrin αIIbβ3 in fibrin-mediated microthrombus formation', Arteriosclerosis Thrombosis and Vascular Biology, vol. 41, no. 2, pp. e97–e111. https://doi.org/10.1161/ATVBAHA.120.314641
Review article
Khattak, S, Townend, JN & Thomas, MR 2024, 'Impact of antiplatelet therapy on microvascular thrombosis during ST-elevation myocardial infarction', Frontiers in Molecular Biosciences, vol. 11, 1287553. https://doi.org/10.3389/fmolb.2024.1287553
Thomas, MR & Nicolson, P 2021, 'Inhibiting novel mechanisms of thrombosis: next-generation antiplatelet therapy', Platelets, vol. 32, no. 1, pp. 5-6. https://doi.org/10.1080/09537104.2020.1853422
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