Our established multi-disciplinary scientific excellence in thrombosis and haemostasis
Thrombosis and Haemostasis encompasses a range of disorders which are collectively the major killers of mankind and are usually triggered by injury to blood vessels and inappropriate activation of platelets and the coagulation system inside a blood vessel. Our theme is made up of multiple individual research groups and brings together clinical and non-clinical academics with multidisciplinary expertise in discovery and translational science. We work very closely with the major NHS trusts across Birmingham including University Hospitals Birmingham, Sandwell and West Birmingham Hospitals and Birmingham Women's and Children's Hospitals, which greatly enhances our translational capabilities.
Theme Lead
Professor Neil Morgan
Professor of Cardiovascular Genetics
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Department of Cardiovascular Sciences Research Theme: Thrombosis and Haemostasis
Theme Lead
Dr Mark Thomas
NIHR Clinical Lecturer
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Our world leading researchers use basic science and translational approaches to address some of the key challenges in thrombosis and haemostasis. From identifying the causes of disease through to improving the treatments options for patients, we investigate platelet and megakaryocyte biology through the use of mouse models and cell biology. Our clinical studies focus on the genetics of patients with rare bleeding disorders and novel antithrombotic strategies for patients with thrombotic disorders.
Our Principal Investigators and Research Groups
Principal Investigators
| Principal Investigators | Research Interest |
|---|
| Professor Dirk-Peter Herten |
Molecular level signalling of inflammation and thrombo-inflammation |
| Professor Neil Morgan |
Identifying novel genes for inherited platelet disorders and associated bleeding and the underlying mechanisms |
| Professor Steve Watson |
Molecular mechanisms of platelet activation |
| Dr Alexander Brill |
Mechanisms of venous thrombosis and interplay between thrombosis and inflammation |
| Dr Pip Nicholson |
Platelet activation, Venous Thromboembolism (VTE), Translational Medicine, Mass participation research |
| Dr Natalie Poulter |
Understanding platelet activation and receptor signalling using advanced microscopy |
| Dr Julie Rayes |
Understanding mechanisms of thromboinflammation in sterile and infectious conditions. In particular, I am interested in danger-associated molecular patterns effect on platelet and how it regulates its interaction with immune and endothelial cells |
| Dr Mark Thomas |
Antithrombotic pharmacology, precision medicine and machine learning |
| Dr Steve Thomas |
Platelet and Megakaryocyte Cytoskeletons, Advanced Fluorescent Microscopy |
Honorary Principal Investigators
| Principal Investigators | Research Interest |
|---|
| Dr Gillian Lowe |
Inherited platelet disorders |
Associate/Affiliate Principal Investigators
| Associate/Affiliate Principal Investigators | Research Interest |
|---|
| Professor Georgios Gkoutos |
Health Data Science, Bioinformatics, Artificial Intelligence for Health, Multmodal multiomics integrative analytics, Translational comparative phenomics, Precision Medicine |
| Dr Paul Harrison |
Platelets, Neutrophils, Extracellular Vesicles, Trauma and Burns |
| Dr Patricia Lalor (Trish) |
Human liver inflammation and fibrosis, endothelial and platelet biology and impact of these on inflammation |
| Dr Michael Tomlinson |
Tetraspanins and associated membrane proteins |
Research Groups
Birmingham Platelet Group