Recent publications
Article
Martin, E, Clark, J, Montague, S, Moran, LA, Di, Y, Bull, LJ, Whittle, L, Raka, F, Buka, R, Zafar, I, Kardeby, C, Slater, A & Watson, S 2024, 'Trivalent nanobody-based ligands mediate powerful activation of GPVI, CLEC-2 and PEAR1 in human platelets whereas FcγRIIA requires a tetravalent ligand', Journal of Thrombosis and Haemostasis, vol. 22, no. 1, pp. 271-285. https://doi.org/10.1016/j.jtha.2023.09.026
Clark, JC, Martin, EM, Morán, LA, Di, Y, Wang, X, Zuidscherwoude, M, Brown, HC, Kavanagh, DM, Hummert, J, Eble, JA, Nieswandt, B, Stegner, D, Pollitt, AY, Herten, D, Tomlinson, MG, García, A & Watson, SP 2023, 'Divalent nanobodies to platelet CLEC-2 can serve as agonists or antagonists', Communications Biology, vol. 6, no. 1, 376. https://doi.org/10.1038/s42003-023-04766-6
Clark, J, Watson, S & Owen, D 2023, 'Validation of agent-based models of surface receptor oligomerisation', Trends in Pharmacological Sciences, vol. 44, no. 10, pp. 643-646. https://doi.org/10.1016/j.tips.2023.07.002
Maqsood, Z, Clark, JC, Martin, EM, Cheung, YFH, Morán, LA, Watson, SET, Pike, JA, Di, Y, Poulter, NS, Slater, A, Lange, BMH, Nieswandt, B, Eble, JA, Tomlinson, MG, Owen, DM, Stegner, D, Bridge, LJ, Wierling, C & Watson, SP 2022, 'Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins', PLoS Computational Biology, vol. 18, no. 11, e1010708. https://doi.org/10.1371/journal.pcbi.1010708
Morán, LA, Di, Y, Sowa, MA, Hermida-Nogueira, L, Barrachina, MN, Martin, E, Clark, JC, Mize, TH, Eble, JA, Moreira, D, Pollitt, AY, Loza, MI, Domínguez, E, Watson, SP & García, Á 2022, 'Katacine is a new ligand of CLEC-2 that acts as a platelet agonist', Thrombosis and Haemostasis, vol. 122, no. 08, pp. 1361-1368. https://doi.org/10.1055/a-1772-1069
Colicchia, M, Schrottmaier, WC, Perrella, G, Reyat, JS, Begum, J, Slater, A, Price, J, Clark, JC, Zhi, Z, Simpson, M, Bourne, J, Poulter, NS, Khan, AO, Nicolson, PLR, Pugh, MR, Harrison, P, Iqbal, AJ, Rainger, GE, Watson, SP, Thomas, MR, Mutch, NJ, Assinger, A & Rayes, J 2022, 'S100A8/A9 drives the formation of procoagulant platelets through GPIbα', Blood. https://doi.org/10.1182/blood.2021014966
Billiald, P, Slater, A, Welin, M, Clark, J, Loyau, S, Pugnière, M, Jiacomini , IG, Rose, N, Lebozec, K, Toledano, E, François, D, Watson, S & Jandrot-Perrus, M 2022, 'Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition', Blood Advances. https://doi.org/10.1182/bloodadvances.2022007863
Clark, J, Neagoe, RAI, Zuidscherwoude, M, Kavanagh, D, Slater, A, Martin, E, Soave, M, Stegner, D, Nieswandt, B, Poulter, N, Hummert, J, Herten, D-P, Tomlinson, M, Hill, SJ & Watson, S 2021, 'Evidence that GPVI is expressed as a mixture of monomers and dimers, and that the D2 domain is not essential for GPVI activation: GPVI dimerisation is not critical for ligand binding', Thrombosis and Haemostasis, vol. 2021, no. 00, pp. 1-26. https://doi.org/10.1055/a-1401-5014
Slater, A, Di, Y, Clark, J, Jooss, N, Martin, E, Alenazy, F, Thomas, MR, Ariëns, RAS, Herr, AB, Poulter, N, Emsley, J & Watson, S 2021, 'Structural characterisation of a novel GPVI nanobody-complex reveals a biologically active domain-swapped GPVI dimer', Blood, vol. 2021, no. 00, pp. 1-20. https://doi.org/10.1182/blood.2020009440
Clark, JC, Damaskinaki, F-N, Cheung, YFH, Slater, A & Watson, SP 2021, 'Structure-function relationship of the platelet glycoprotein VI (GPVI) receptor: does it matter if it is a dimer or monomer?', Platelets, vol. 32, no. 6, pp. 724-732. https://doi.org/10.1080/09537104.2021.1887469
Clark, J, Kavanagh, D, Watson, S, Pike, J, Andrews, R, Gardiner, EE, Poulter, N, Hill, SJ & Watson, S 2019, 'Adenosine and forskolin inhibit platelet aggregation by collagen but not the proximal signalling events', Thrombosis and Haemostasis, vol. 119, no. 07, pp. 1124-1137. https://doi.org/10.1055/s-0039-1688788
View all publications in research portal