Dr Jocelyn Auger

Institute of Cardiovascular Sciences
Daphne Jackson Postdoctoral Research Fellow

Contact details

Email: j.m.auger.1@bham.ac.uk

Address: University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Jocelyn is a Daphne Jackson Fellow, pleased to be back to research after a career break, funded by the British Heart Foundation. She is a Biochemistry graduate from Oxford University, with PhD and postdoctoral experience at Birmingham and Maastricht Universities.

Qualifications

PhD in Medicine, University of Birmingham, 2006
MBioch in Molecular and Cellular Biochemistry, University of Oxford, 2002

Biography

Jocelyn entered the cardiovascular research field in 2001 as an undergraduate student at the University of Oxford. Her subsequent PhD at the University of Birmingham was supervised by Professor Steve Watson and funded by the British Heart Foundation. This included a Marie Curie Fellowship for a research project at Maastricht University in 2003, supervised by Professor Johan Heemskerk. Jocelyn started her first postdoctoral position in 2005, funded by the Wellcome Trust. She is author on 22 publications between 2003 and 2010, and gave numerous oral and poster presentations at international meetings and conferences. Jocelyn began a career break in 2009, before returning to research in 2024 as a Daphne Jackson Fellow, funded by the British Heart Foundation, supervised by Dr Steve Thomas and Dr Natalie Poulter.

Research

Jocelyn’s research interests lie in thrombosis, specifically in understanding the detailed interactions between platelets, blood vessels and other cells. Her PhD involved identifying the roles of many specific cytoskeletal proteins and signalling pathways underlying thrombosis in an in vitro flow model. Her postdoctoral work took this further to confirming the importance in in vivo mouse models.

Jocelyn’s current project involves incorporating endothelial cells into an in vitro microfluidic flow model, to develop a tool for application of novel imaging techniques.

Publications

Recent publications

Article

Berny, MA, Munnix, ICA, Auger, JM, Schols, SEM, Cosemans, JMEM, Panizzi, P, Bock, PE, Watson, S, McCarty, OJT & Heemskerk, JWM 2010, 'Spatial Distribution of Factor Xa, Thrombin, and Fibrin(ogen) on Thrombi at Venous Shear', PLoS ONE, vol. 5, no. 4, e10415. https://doi.org/10.1371/journal.pone.0010415

van der Meijden, PEJ, Munnix, ICA, Auger, J, Govers-Riemslag, JWP, Cosemans, JMEM, Kuijpers, MJE, Spronk, HM, Watson, S, Renne, T & Heemskerk, JWM 2009, 'Dual role of collagen in factor XII-dependent thrombus formation', Blood, vol. 114, no. 4, pp. 881-890. https://doi.org/10.1182/blood-2008-07-171066

Senis, Y, Tomlinson, M, Ellison, S, Mazharian, A, Lim, J, Zhao, Y, Kornerup, K, Auger, J, Thomas, S, Dhanjal, T, Kalia, N, Zhu, JW, Weiss, A & Watson, S 2009, 'The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis', Blood, vol. 113, no. 20, pp. 4942-4954. https://doi.org/10.1182/blood-2008-08-174318

Kalia, N, Auger, J, Atkinson, B & Watson, S 2008, 'Critical role of FcR gamma-chain, LAT, PLCgamma2 and thrombin in arteriolar thrombus formation upon mild, laser-induced endothelial injury in vivo.', Microcirculation, vol. 15, no. 4, pp. 325-35. https://doi.org/10.1080/10739680701728822

Pears, CJ, Thornber, K, Auger, J, Hughes, C, Grygielska, B, Pearce, AC, Protty, MB & Watson, S 2008, 'Differential Roles of the PKC Novel Isoforms, PKCδ and PKCε, in Mouse and Human Platelets', PLoS ONE, vol. 3, no. 11, pp. e3793-. https://doi.org/10.1371/journal.pone.0003793

Hughes, C, Auger, J, McGlade, J, Eble, JA, Pearce, AC & Watson, S 2008, 'Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2.', Journal of Thrombosis and Haemostasis, vol. 6, no. 12, pp. 2152-9. https://doi.org/10.1111/j.1538-7836.2008.03166.x

Auger, J & Watson, S 2008, 'Dynamic tyrosine kinase-regulated signaling and actin polymerisation mediate aggregate stability under shear.', Arteriosclerosis Thrombosis and Vascular Biology, vol. 28, no. 8, pp. 1499-504. https://doi.org/10.1161/ATVBAHA.108.167296

Calaminus, S, McCarty, OJ, Auger, J, Pearce, A, Insall, R, Watson, S & Machesky, L 2007, 'A major role for Scar/WAVE-1 downstream of GPVI in platelets', Journal of Thrombosis and Haemostasis, vol. 5, no. 3, pp. 535-541. https://doi.org/10.1111/j.1538-7836.2007.02377.x

Tomlinson, M, Calaminus, S, Berlanga, O, Auger, J, Bori-Sanz, T, Meyaard, L & Watson, S 2007, 'Collagen promotes sustained glycoprotein VI signaling in platelets and cell lines', Journal of Thrombosis and Haemostasis, vol. 5, no. 11, pp. 2274-2283. https://doi.org/10.1111/j.1538-7836.2007.02746.x

Dhanjal, T, Ross, E, Auger, J, McCarty, O, Hughes, C, Senis, Y, Buckley, C & Watson, S 2007, 'Minimal regulation of platelet activity by PECAM-1', Platelets, vol. 18, no. 1, pp. 56-67. https://doi.org/10.1080/09537100600881396

Dhanjal, T, Ross, E, Auger, J, Mccarty, OJT, Hughes, C, Senis, Y, Buckley, C & Watson, S 2007, 'Minimal regulation of platelet activity by PECAM-1 (vol 18, pg 56, 2007)', Platelets, vol. 18, no. 6, pp. 472-472. https://doi.org/10.1080/09537100701612831

Calaminus, S, Auger, J, McCarty, OJ, Wakelam, M, Machesky, L & Watson, S 2007, 'MyosinIIa contractility is required for maintenance of platelet structure during spreading on collagen and contributes to thrombus stability.', Journal of Thrombosis and Haemostasis, vol. 5, no. 10, pp. 2136-45. https://doi.org/10.1111/j.1538-7836.2007.02696.x

Munnix, ICA, Kuijpers, MJE, Auger, J & Watson, S 2007, 'Segregation of platelet aggregatory and procoagulant Microdomains in thrombus formation - Regulation by transient integrin activation', Arteriosclerosis Thrombosis and Vascular Biology, vol. 27, no. 11, pp. 2484-2490. https://doi.org/10.1161/ATVBAHA.107.151100

Thomas, S, Calaminus, S, Auger, J, Watson, S & Machesky, L 2007, 'Studies on the actin-binding protein HS1 in platelets', BMC Cell Biology, vol. 8, 46. https://doi.org/10.1186/1471-2121-8-46

Review article

Munnix, I, Cosemans, J, Auger, J & Heemskerk, J 2009, 'Platelet response heterogeneity in thrombus formation', Thrombosis and Haemostasis, vol. 102, no. 6, pp. 1149-1156. https://doi.org/10.1160/TH09-05-0289

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