Dr Sandeep Potluri MB BChir (Cantab), FRCPath, PhD

Dr Sandeep Potluri

Institute of Cancer and Genomic Sciences
BHP Clinician-Scientist
Consultant Paediatric Haematologist/ Stem Cell Transplantation

Contact details

Email
s.potluri@bham.ac.uk
Twitter
@sandeeppotluri3
Address
Institute of Cancer and Genomic Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr Sandeep Potluri is a BHP Clinician-Scientist in the Institute of Cancer and Genomic Sciences at the University of Birmingham and a Consultant in Paediatric Haematologist/ Stem Cell Transplantation at Birmingham Children’s Hospital. 

His interests are in paediatric congenital conditions that confer a propensity to leukaemia, therapeutic vulnerabilities in Acute Myeloid Leukaemia and ways of optimising conditioning therapies for allogeneic stem cell transplantation.

Qualifications

  • FRCPath (Fellowship of the Royal College of Pathologists), 2023
  • PhD in Genomics and Cancer Sciences, University of Birmingham, 2021
  • MRCP (Membership of the Royal College of Physicians), 2014
  • MA (Cantab), University of Cambridge, 2013
  • MB BChir (Cantab), University of Cambridge, 2012
  • BA (Cantab), University of Cambridge, 2009

Biography

Following graduation from the University of Cambridge, Dr Sandeep Potluri joined the Academic Foundation Programme in Newcastle upon Tyne Hospitals/ Newcastle University where he worked on identifying novel driver mutations and also the epigenomic profiling of paediatric tumours. 

Dr Potluri then moved to Birmingham as an NIHR funded Academic Clinical Fellow in Haematology. He obtained a Medical Research Council funded Clinical Research Training Fellowship which allowed him to undertake a PhD in Professor Constanze Bonifer’s lab in the Institute of Cancer and Genomic Sciences here at the University of Birmingham. Dr Potluri investigated how transcription factor networks are corrupted in Acute Myeloid Leukaemia with a specific focus on WT1 and the AP-1 family of transcription factors. He has also been looking into characterising leukaemic stem cells and identifying therapeutic vulnerabilities. 

Dr Potluri has also spent periods of time at Stanford University, USA and at the Mayo Clinic, Rochester, USA working with the oncology and leukaemia services and with the epigenomics program.

Following completion of his clinical training, he was appointed as a BHP Clinician Scientist and as a consultant in Paediatric Haematology/ Stem Cell Transplantation. 

Postgraduate supervision

Sandeep would be happy to be contacted by potential postgraduate students. Please email a copy of your CV and an outline of research interests.

Research

Dr Sandeep Potluri is interested in congenital leukaemia pre-disposition syndromes in children and how they give rise to acute leukaemia, whether that be through corruption of transcription factor networks or through disturbance of the DNA damage response. 

Many of these children have significant toxicity to chemotherapy or stem cell transplant conditioning therapies and Dr Potluri is looking into synthetic lethality approaches, so that methods using reduced doses of chemotherapy may be utilised. 

Dr Potluri works on primary patient bone marrow, fibroblasts, LCLs and also leukaemic cell lines derived from patients.

Publications

Stanulović V, Al Omair S, Reed MAC, Roberts J, Sandeep Potluri, Fulton-Ward T, Gudgeon N, Bishop EL, Roels J, Perry TA, Sarkar S, Pratt G, Taghon T, Dimeloe S, Günther UL, Ludwig C, Hoogenkamp M.  The Glutamate/Aspartate Transporter EAAT1 is Crucial for T-cell Acute Lymphoblastic Leukaemia Proliferation and Survival. Haematologica 2024 2024 May 30. doi: 10.3324/haematol.2023.283471 

Coleman DJL, Keane P, Chin PS, Ames L, Kellaway S, Blair H, Khan N, Griffin J, Holmes E, Maytum A, Sandeep Potluri, Strate L, Koscielniak K, Raghavan M, Bushweller J, Heidenreich O, Rabbitts T, Cockerill PN, Bonifer C. Pharmacological Inhibition of RAS Overcomes FLT3 Inhibitor Resistance in FLT3-ITD+ AML through AP-1 and RUNX1 iScience 2024 Mar 26. 

Kellaway S, Sandeep Potluri, Keane P, Chin PS, Ptasinska A, Worker A, Ames A, Coleman DJL, Adamo A, Assi SA, Blair H, Heidenreich O, Cockerill PN, Bonifer C. Leukemic Stem Cells Hijack Lineage Inappropriate Signalling Pathways to Promote Growth Nature Communications 2024 Feb 14;15(1):1359 

Sandeep Potluri, Coleman DJL, Assi SA, Cockerill PN, Bonifer C. Gene regulation in t(6;9) DEK::NUP214 Acute Myeloid Leukemia Resembles that of FLT3-ITD/NPM1 Acute Myeloid Leukemia but with an Altered HOX/MEIS Axis Leukemia 2024 Feb;38(2):403-407. doi: 10.1038/s41375-023-02118-1 

Coleman DJL, Keane P, Luque-Martin R, Chin PS, Blair H, Ames L, Kellaway SG, Griffin J, Holmes E, Sandeep Potluri, Assi SA, Bushweller J, Heidenreich O, Cockerill PN, Bonifer C Gene Regulatory Network Analysis Predicts Cooperating Transcription Factor Regulons Required for FLT3-ITD+ AML Growth Cell Reports 2023 Dec 15;42(12):113568. 

Adamo A, Chin P, Keane P, Assi SA, Sandeep Potluri, Kellaway SG, Coleman C, Ames L, Ptasinska A, Delwel H, Cockerill PN, Bonifer C.  Identification and Interrogation of the Gene Regulatory Network of CEBPA-Double Mutant Acute Myeloid Leukemia  Leukemia 2022 Nov 4. doi: 10.1038/s41375-022-01744-5 

Stavrou V, Fultang L, Booth S, De Simone D, Bartnik A, Scarpa U, Gneo L, Panetti S, Sandeep Potluri, Almowaled M, Barlow J, Jankevics A, Lloyd G, Southam A, Priestman DA, Cheng P, Dunn W, Platt F, Endou, Craddock C, Keeshan K, Mussai F, De Santo C.  Invariant NKT cells Metabolically Adapt to the Acute Myeloid Leukaemia Environment. Cancer Immunol Immunother 2022 Aug 13. doi: 10.1007/s00262-022-03268-4 

Vilaplana-Lopera N, Almaghrabi R, Papatzikas G, González E, Cunningham A, Erdem A, Schnuetgen F, Raghavan M, Sandeep Potluri, Cazier JB, Schuringa JJ, Reed MAC, Garcia P, Günther UL. Crosstalk between AML and Stromal Cells Triggers Acetate Secretion through the Metabolic Rewiring of Stromal Cells eLife 2022 https://doi.org/10.7554/eLife.75908 

Binder M, Carr RM, Lasho TL, Finke CM, Mangaonkar AA, Pin CL, Berger KR, Sandeep Potluri, Ordog T, Robertson KD, Marks DL, Fernandez-Zapico ME, Gaspar-Maia A, Patnaik MM.  Oncogenic Gene Expression and Epigenetic Remodeling of Cis-regulatory Elements in ASXL1-mutant Chronic Myelomonocytic Leukemia  Nature Communications 2022 13, 1434 

Sandeep Potluri, Assi SA, Chin PS, Coleman DJL, Pickin A, Moriya S, Seki N, Heidenreich O, Cockerill PN, Bonifer C.  Isoform-Specific and Signaling-Dependent Propagation of Acute Myeloid Leukemia by Wilms Tumor 1  Cell Reports 2021 Apr 20;35(3):109010. doi: 10.1016/j.celrep.2021.109010 

Sandeep Potluri  Treatment-Free Remission in Chronic Myeloid Leukaemia Karger Publishing Group ISBN 978-1-912776-18-4 (Book) 

Simon V, Rakhshan F, Sandeep Potluri, Mazzone A, Li Y, Eckloff B, Cunningham J, Gaspar Maia A.  Mapping Regulatory Elements Using Single- cell ATAC-Seq  Journal of Biomolecular Techniques 2020 Aug;31 

Assi SA, Imperato MR, Coleman DJL, Pickin A, Sandeep Potluri, Ptasinska A, Chin PS, Blair H, Cauchy P, James SR, Zacarias-Cabeza J, Gilding LN, Beggs A, Clokie S, Loke JC, Jenkin P, Uddin A, Delwel R, Richards SJ, Raghavan M, Griffiths MJ, Heidenreich O, Cockerill PN and Bonifer C  Subtype-specific regulatory network rewiring in acute myeloid leukemia Nature Genetics 2019 Jan;51(1):151-162 

Martinez-Soria N, McKenzie L, Draper J, Ptasinska A, Issa H, Sandeep Potluri, Blair HJ, Pickin A, Isa A, Chin PS, Tirtakusuma R, Coleman D, Nakjang S, Assi S, Forster V, Reza M, Law E, Berry P, Mueller D, Elder A, Bomken SN, Pal D, Allan JM, Veal GJ, Cockerill PN, Wichmann C, Vormoor J, Lacaud G, Bonifer and Heidenreich O  The Oncogenic Transcription Factor RUNX1/ETO Corrupts the Cell Cycle to Drive Leukemic Transformation Cancer Cell 2018 Oct 8;34(4):626-642.e8 

Sandeep Potluri, Coleman D and Bonifer C Pharmacological Inhibition of Aberrant Transcription Factor Complexes in Inversion 16 Acute Myeloid Leukemia.  Stem Cell Investigation 2018, 5:30 

Schwalbe EC, Hicks D, Rafiee G, Bashton M, Gohlke H, Enshaei A, Sandeep Potluri, Matthiesen J, Mather M, Taleongpong P, Chaston R, Silmon A, Curtis A, Lindsey JC, Crosier S, Smith AJ, Goschzik T, Doz F, Rutkowski S, Lannering B, Pietsch T, Bailey S, Williamson D, Clifford SC  Minimal methylation classifier (MIMIC): A Novel Method for Derivation and Rapid Diagnostic Detection of Disease-associated DNA Methylation Signatures  Nature Scientific Reports 2017 Oct 18;7(1):13421 

Lindsey J, Schwalbe E, Sandeep Potluri, Bailey S, Williamson D and Clifford SC.  TERT Promoter Mutation and Aberrant Hypermethylation are Associated with Elevated Expression in Medulloblastoma and Characterise the Majority of Non-infant SHH Subgroup Tumours  Acta Neuropathologica 2014 Feb;127(2):307-9 

Alduaij W, Ivanov A, Honeychurch J, Cheadle E, Sandeep Potluri, Lim SH, Shimada K, Chan CHT, Tutt A, Beers SA, Glennie MJ, Cragg MS, Illidge TM.  Novel Type II Anti-CD20 Monoclonal Antibody (GA101) Evokes Homotypic Adhesion and Actin-Dependent, Lysosome-Mediated Cell Death in B-cell Malignancies  Blood 2011 Apr 28;117(17):4519-29 

Sandeep Potluri, Jefferies SJ, Jena R, Harris F, Burton K, Prevost T, Burnet NG.  Residual Postoperative Tumour Volume Predicts Outcome after High-dose Radiotherapy for Chordoma and Chondrosarcoma of the Skull Base and Spine Clinical Oncology 2011 Apr;23(3):199-208