Recent publications
Article
Saleh, H, Liloglou, T, Rigden, DJ, Parsons, JL & Grundy, GJ 2024, 'KH-like Domains in PARP9/DTX3L and PARP14 Coordinate Protein–Protein Interactions to Promote Cancer Cell Survival', Journal of Molecular Biology, vol. 436, no. 4, 168434. https://doi.org/10.1016/j.jmb.2023.168434
Fabbrizi, MR, Nickson, CM, Hughes, JR, Robinson, EA, Vaidya, K, Rubbi, CP, Kacperek, A, Bryant, HE, Helleday, T & Parsons, J 2024, 'Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence', Cell Death and Disease, vol. 15, no. 2, 150. https://doi.org/10.1038/s41419-024-06541-9
Guerra Liberal, FDC, Parsons, JL & McMahon, SJ 2023, 'Most DNA repair defects do not modify the relationship between relative biological effectiveness and linear energy transfer in CRISPR‐edited cells', Medical Physics. https://doi.org/10.1002/mp.16764
Mellone, M, Piotrowska, K, Venturi, G, James, L, Bzura, A, Lopez, MA, James, S, Wang, C, Ellis, MJ, Hanley, CJ, Buckingham, JF, Cox, KL, Hughes, G, Valge-Archer, V, King, EV, Beers, SA, Jaquet, V, Jones, GDD, Savelyeva, N, Sayan, E, Parsons, JL, Durant, S & Thomas, GJ 2022, 'ATM regulates differentiation of myofibroblastic cancer-associated fibroblasts and can be targeted to overcome immunotherapy resistance', Cancer Research, vol. 82, no. 24, pp. 4571-4585. https://doi.org/10.1158/0008-5472.CAN-22-0435
Fabbrizi, MR & Parsons, JL 2022, 'Cell death mechanisms in head and neck cancer cells in response to low and high-LET radiation', Expert Reviews in Molecular Medicine, vol. 24, e2. https://doi.org/10.1017/erm.2021.31
Zhou, C, Fabbrizi, MR, Hughes, JR, Grundy, GJ & Parsons, JL 2022, 'Effectiveness of PARP inhibition in enhancing the radiosensitivity of 3D spheroids of head and neck squamous cell carcinoma', Frontiers in Oncology, vol. 12, 940377. https://doi.org/10.3389/fonc.2022.940377
Antrobus, J & Parsons, J 2022, 'Histone deacetylases and their potential as targets to enhance tumour radiosensitisation', Radiation, vol. 2, no. 1, pp. 149-167. https://doi.org/10.3390/radiation2010011
Konis, SMR, Hughes, JR & Parsons, JL 2022, 'TRIM26 maintains cell survival in response to oxidative stress through regulating DNA glycosylase stability', International Journal of Molecular Sciences, vol. 23, no. 19, 11613. https://doi.org/10.3390/ijms231911613
Fabbrizi, MR, Hughes, JR & Parsons, JL 2021, 'The enzyme-modified neutral comet (EMNC) assay for complex DNA damage detection', Methods and Protocols, vol. 4, no. 1, 14. https://doi.org/10.3390/mps4010014
Nickson, CM, Fabbrizi, MR, Carter, RJ, Hughes, JR, Kacperek, A, Hill, MA & Parsons, JL 2021, 'USP9X is required to maintain cell survival in response to high-LET radiation', Frontiers in Oncology, vol. 11, 671431. https://doi.org/10.3389/fonc.2021.671431
Abstract
Fabbrizi, MR, Nickson, CM, Carter, RJ, Hughes, JR, Kacperek, A, Hill, MA & Parsons, JL 2021, 'USP9X Inhibition Enhances Radiosensitisation of Head and Neck Cancer Cells in Response to High-LET Radiation by Destabilising Centrosome Proteins', Medical Sciences Forum, vol. 3, no. 1, 2, pp. 1. https://doi.org/10.3390/IECC2021-09211
Review article
Melia, E & Parsons, JL 2023, 'DNA damage and repair dependencies of ionising radiation modalities', Bioscience Reports, vol. 43, no. 10, BSR20222586. https://doi.org/10.1042/BSR20222586
Wilkinson, B, Hill, MA & Parsons, JL 2023, 'The Cellular Response to Complex DNA Damage Induced by Ionising Radiation', International Journal of Molecular Sciences, vol. 24, no. 5, 4920. https://doi.org/10.3390/ijms24054920
Aiyappa-Maudsley, R, Chalmers, AJ & Parsons, JL 2022, 'Factors affecting the radiation response in glioblastoma', Neuro-oncology advances, vol. 4, no. 1, vdac156. https://doi.org/10.1093/noajnl/vdac156
Hill, RM, Rocha, S & Parsons, JL 2022, 'Overcoming the impact of hypoxia in driving radiotherapy resistance in head and neck squamous cell carcinoma', Cancers, vol. 14, no. 17, 4130. https://doi.org/10.3390/cancers14174130
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