Recent publications
Article
Jones, RM, Ruiz, JH, Scaramuzza, S, Nath, S, Liu, C, Henklewska, M, Natsume, T, Bristow, RG, Romero, F, Kanemaki, MT & Gambus, A 2024, 'Characterizing replisome disassembly in human cells', iScience, vol. 27, no. 7, 110260. https://doi.org/10.1016/j.isci.2024.110260
Passaretti, P, Cvetkovic, MA, Costa, A & Gambus, A 2024, 'Protocol for the purification of replisomes from the Xenopus laevis egg extract system for single-particle cryo-EM analysis', STAR Protocols, vol. 5, no. 3, 103237. https://doi.org/10.1016/j.xpro.2024.103237
Kingsley, G, Skagia, A, Passaretti, P, Fernandez-Cuesta, C, Reynolds-Winczura, A, Koscielniak, K & Gambus, A 2023, 'DONSON facilitates Cdc45 and GINS chromatin association and is essential for DNA replication initiation', Nucleic Acids Research. https://doi.org/10.1093/nar/gkad694
Cvetković, M, Passaretti, P, Butryn, A, Reynolds-Winczura, A, Kingsley, G, Skagia, A, Fernandez Cuesta, C, Poovathumkadavil, D, George, R, Chauhan, A, Jhujh, S, Stewart, G, Gambus, A & Costa, A 2023, 'The structural mechanism of dimeric DONSON in replicative helicase activation', Molecular Cell, vol. 83, no. 22, pp. 4017-4031.e9. https://doi.org/10.1016/j.molcel.2023.09.029
Scaramuzza, S, Jones, RM, Sadurni, MM, Reynolds-Winczura, A, Poovathumkadavil, D, Farrell, A, Natsume, T, Rojas, P, Cuesta, CF, Kanemaki, MT, Saponaro, M & Gambus, A 2023, 'TRAIP resolves DNA replication-transcription conflicts during the S-phase of unperturbed cells', Nature Communications, vol. 14, no. 1, 5071. https://doi.org/10.1038/s41467-023-40695-y
Tarcan, Z, Poovathumkadavil, D, Skagia, A & Gambus, A 2022, 'The p97 segregase cofactor Ubxn7 facilitates replisome disassembly during S-phase', The Journal of biological chemistry, vol. 298, no. 8, 102234. https://doi.org/10.1016/j.jbc.2022.102234
Blakemore, D, Vilaplana-Lopera, N, Almaghrabi, R, Gonzalez, E, Moya, M, Ward, C, Murphy, G, Gambus, A, Petermann, E, Stewart, GS & García, P 2021, 'MYBL2 and ATM suppress replication stress in pluripotent stem cells', EMBO Reports, vol. 22, no. 5, e51120. https://doi.org/10.15252/embr.202051120
Hadzhiev, Y, Qureshi, HK, Wheatley, L, Cooper, L, Jasiulewicz, A, Van Nguyen, H, Wragg, JW, Poovathumkadavil, D, Conic, S, Bajan, S, Sik, A, Hutvàgner, G, Tora, L, Gambus, A, Fossey, JS & Müller, F 2019, 'A cell cycle-coordinated Polymerase II transcription compartment encompasses gene expression before global genome activation', Nature Communications, vol. 10, no. 1, 691, pp. 691. https://doi.org/10.1038/s41467-019-08487-5
Moreno, SP, Jones, RM, Poovathumkadavil, D, Scaramuzza, S & Gambus, A 2019, 'Mitotic replisome disassembly depends on TRAIP ubiquitin ligase activity', Life Science Alliance, vol. 2, no. 2, e201900390. https://doi.org/10.26508/lsa.201900390
Sonnerville, R, Priego Moreno, S, Knebel, A, Johnson, C, Hastle, CJ, Gartner, A, Gambus, A & Labib, K 2017, 'CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis', Nature Cell Biology, vol. 19, pp. 468–479. https://doi.org/10.1038/ncb3500
Chapter (peer-reviewed)
Gambus, A 2018, Termination of Eukaryotic Replication Forks. in DNA Replication: From Old Principles to New Discoveries. vol. 1042, Advances in Experimental Medicine and Biology, vol. 1042, Springer, pp. 163-187. https://doi.org/10.1007/978-981-10-6955-0_8
Preprint
Scaramuzza, S, Muste Sadurni, M, Poovathumkadavil, D, Natsume, T, Rojas, P, Kanemaki, MT, Saponaro, M & Gambus, A 2022 'Ubiquitin ligase TRAIP plays an essential role during the S-phase of unperturbed cell cycle in the resolution of DNA replication – transcription conflicts' bioRxiv. https://doi.org/10.1101/2022.03.23.485338
Review article
Jones, RM, Reynolds-Winczura, A & Gambus, A 2024, 'A Decade of Discovery: Eukaryotic Replisome Disassembly at Replication Termination', Biology, vol. 13, no. 4, 233. https://doi.org/10.3390/biology13040233
Moreno, SP & Gambus, A 2020, 'Mechanisms of eukaryotic replisome disassembly', Biochemical Society Transactions, vol. 48, no. 3, pp. 823-836. https://doi.org/10.1042/BST20190363
Working paper
Gambus, A, Moreno, SP, Jones, RM & Poovathumkadavil, D 2018 'Mitotic replisome disassembly in vertebrates' bioRxiv, pp. 1-27. https://doi.org/10.1101/418368
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