Dr Oliver Hale PhD, MSc, BSc (Hons)

Dr Oliver Hale

School of Biosciences
Research Fellow

Dr Oliver Hale is a postdoctoral research fellow who specializes in mass spectrometry. His current focus is on combing native mass spectrometry analysis of intact proteins and mass spectrometry imaging, as part of the EPSRC-funded NAMS project.

Qualifications

PhD in Chemistry

MSc in Chemical Research

BSc (Hons) Chemistry

Biography

Dr Oliver Hale completed his PhD in Chemistry at the University of Reading, which involved the development of atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry (AP-MALDI MS) for the analysis of liquid samples. Since April 2019, Oliver is a postdoctoral research fellow in the Cooper Group in the School of Biosciences at the University of Birmingham.

Research

Development of mass spectrometry instrumentation for mass spectrometry imaging and proteomics.

Publications

(1) Hale, O. J.; Sisley, E. K.; Griffiths, R. L.; Styles, I. B.; Cooper, H. J. Native LESA TWIMS-MSI: Spatial, Conformational, and Mass Analysis of Proteins and Protein Complexes J Am Soc Mass Spectrom 2020, 31, 873-879.

(2) Hale, O. J.; Illes-Toth, E.; Mize, T. H.; Cooper, H. J. High-Field Asymmetric Waveform Ion Mobility Spectrometry and Native Mass Spectrometry: Analysis of Intact Protein Assemblies and Protein Complexes Anal Chem 2020.

(3) Hale, O. J.; Cooper, H. J. In situ mass spectrometry analysis of intact proteins and protein complexes from biological substrates Biochemical Society Transactions 2020, 48, 317-326.

(4) Hale, O. J.; Morris, M.; Jones, B.; Reynolds, C. K.; Cramer, R. Liquid Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Adds Enhanced Functionalities to MALDI MS Profiling for Disease Diagnostics ACS Omega 2019, 4, 12759-12765.

(5) Hale, O. J.; Cramer, R. Atmospheric Pressure Ultraviolet Laser Desorption and Ionization from Liquid Samples for Native Mass Spectrometry Anal Chem 2019, 91, 14192-14197.

(6) Hale, O. J.; Ryumin, P.; Brown, J. M.; Morris, M.; Cramer, R. Production and analysis of multiply charged negative ions by liquid atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry Rapid Communications in Mass Spectrometry 2018, 0.

(7) Hale, O. J.; Cramer, R. Collision-induced dissociation of doubly-charged barium-cationized lipids generated from liquid samples by atmospheric pressure matrix-assisted laser desorption/ionization provides structurally diagnostic product ions Anal Bioanal Chem 2018, 410, 1435-1444.

(8) Timms, J. F.; Hale, O. J.; Cramer, R. Advances in mass spectrometry-based cancer research and analysis: from cancer proteomics to clinical diagnostics Expert review of proteomics 2016, 13, 593-607.

View all publications in research portal