Dr Xin Gao PhD

School of Biosciences
Research fellow

Contact details

Telephone: 07512245766
Email: x.gao.2@bham.ac.uk

Dr. Xin Gao is currently focused on employing advanced biophysical techniques to study the RAS family of proteins for novel cancer therapies. This interest complements their extensive background in protein engineering and immunological research, showcasing a commitment to innovative therapeutic development.

Biography

Dr. Xin Gao, with a Ph.D. from University College London, is an exceptional scientist specializing in immunological protein structures and molecular biology. Expert in protein engineering, immunodetection, structural biology, Dr. Gao's proficiency is key to advancing antibody therapeutics. Their significant research on anti-COVID-19 antibodies and CD64-IgG interactions is published in renowned journals. Currently, Dr. Gao is deeply interested in applying biophysical techniques to investigate the RAS family of proteins, aiming to discover novel therapeutic approaches for cancer treatment. This focus demonstrates Dr. Gao's commitment to leveraging their comprehensive skill set for groundbreaking cancer therapeutics, highlighting a blend of academic excellence, industry experience, and a passion for innovative biotech solutions.

Research

Structural biology, biophysical, antibody, KRas, cancer

Publications

Highlight publications

Gao, X, Iqbal, H, Yu, D-Q, Gor, J, Coker, AR & Perkins, SJ 2024, 'The SCR-17 and SCR-18 glycans in human complement Factor H enhance its regulatory function', Journal of Biological Chemistry, vol. 300, no. 9, 107624. https://doi.org/10.1016/j.jbc.2024.107624

Gao, X, Thrush, JW, Gor, J, Naismith, JH, Owens, RJ & Perkins, SJ 2023, 'The solution structure of the heavy chain–only C5-Fc nanobody reveals exposed variable regions that are optimal for COVID-19 antigen interactions', Journal of Biological Chemistry, vol. 299, no. 11, 105337. https://doi.org/10.1016/j.jbc.2023.105337

Hui, GK, Gao, X, Gor, J, Lu, J, Sun, PD & Perkins, SJ 2023, 'The solution structure of the unbound IgG Fc receptor CD64 resembles its crystal structure: Implications for function', PLoS ONE, vol. 18, no. 9, e0288351. https://doi.org/10.1371/journal.pone.0288351

Dunne, OM, Gao, X, Nan, R, Gor, J, Adamson, PJ, Gordon, DL, Moulin, M, Haertlein, M, Forsyth, VT & Perkins, SJ 2021, 'A Dimerization Site at SCR-17/18 in Factor H Clarifies a New Mechanism for Complement Regulatory Control', Frontiers in immunology, vol. 11, 601895. https://doi.org/10.3389/fimmu.2020.601895

Recent publications

Article

Tang, J, Zhang, C, Castillo, NC, Lalaurie, CJ, Gao, X, Dalby, PA & Kozielski, F 2023, 'Crystal structures and molecular dynamics simulations of a humanised antibody fragment at acidic to basic pH', Scientific Reports, vol. 13, 16281. https://doi.org/10.1038/s41598-023-42698-7

Preprint

Bradford, HF, Lalaurie, C, Gor, J, Gao, X, Pericleous, C, Perkins, SJ, Britt, H, Thalassinos, K, Giles, IP, Rahman, A, Delcea, M, Dalby, PA & McDonnell, TCR 2024 'Plasmin Cleavage of Beta-2-Glycoprotein I Alters its Structure and Ability to Bind to Pathogenic Antibodies' medRxiv, pp. 1-26. https://doi.org/10.1101/2024.04.12.24305747

View all publications in research portal