Mr David Winter HNC

Department of Applied Health Sciences
I.T. Manager

Contact details

Telephone: +44 (0)121 414 6766
Fax: +44 (0)121 414 7923
Email: d.l.winter@bham.ac.uk

Address: Centre for Childhood Cancer Survivor Studies
Institute of Applied Health Research
Robert Aitken Building
University of Birmingham
Edgbaston
Birmingham, B15 2TY, UK

David is the I.T. Manager for the Centre for Childhood Cancer Survivor Studies (CCCSS). He started his career in Oxford in 1982 and moved to the University of Birmingham in 1998. He has been an author on over 20 peer-reviewed publications in the field of childhood cancer epidemiology.

Qualifications

HNC in Computing & Mathematics, Oxford Brookes University, 1991

Biography

Born and educated in Oxford, David joined the Childhood Cancer Research Group (CCRG) at the University of Oxford in February 1982, having previously trained at the Oxford University Computing Service. At CCRG he provided Research/Computing Support on the Long-Term Follow-Up Study (LTF) until November 1998 when he moved to the Centre for Childhood Cancer Survivor Studies (CCCSS)

Research

The Centre for Childhood Cancer Survivor Studies was established in 1998 to carry out the British Childhood Cancer Survivor Study (BCCSS). The BCCSS comprises 17,981 individuals who were diagnosed with cancer aged 0-14 years inclusive, between 1940 and 1991 in Britain, and who survived 5 years.

The Centre maintains excellent links with clinicians who are members of the Children's Cancer and Leukaemia Group (CCLG), formerly the United Kingdom Children’s Cancer Study Group (UKCCSG) who treat and follow-up the majority of children diagnosed with cancer in the UK. There are also close collaborative research links with the Childhood Cancer Research Group, based at the University of Oxford, which maintains the population-based National Registry of Childhood Tumours.

The Centre is well known internationally through its publications and attendance at most important meetings concerned with survivors of childhood cancer. Collaborative international studies of the adverse consequences of irradiation in childhood have been undertaken including data relating to survivors of the atomic bombs in Japan. There is an established international collaborative programme of studies of the incidence and aetiology of second primary neoplasms after childhood cancer in Britain and France ongoing funded by the European Union. Good links exist with the Childhood Cancer Survivor Study which is ongoing in North America and co-ordinated from St Jude Children's Research Hospital in Memphis. In addition, there are international collaborative initiatives, in particular an international study of the rates and causes of second primary tumours after Wilms’ tumour is being developed and an international collaborative study of the joint influences of radiation and genotype on breast cancer risk is on-going and is funded by the European Union under the 6th Framework Programme.

The Centre has contributed substantially to an international collaborative pan-European study (‘PanCareSurFup’), involving most European countries, initiated in 2011 and funded by the EC for five years, which provides the largest ever investigation of the risks of causes of late deaths, subsequent primary cancers and cardiac conditions in survivors of childhood cancer. The Centre will co-ordinate and host the web-based data collection and subsequent analysis components of this study and David will be responsible for the design, implementation and management of the hardware and software systems required.

Publications

Brabant, G., Toogood, A.A., Shalet, S.M., Frobisher, C., Lancashire, E., Reulen, R., Winter, D., Hawkins, M.M. (2012) Hypothyroidism following childhood cancer therapy – An under diagnosed complication. Int. J. Cancer, 130(5): 1145-1150

Rebholz, C.E., Reulen, R.C., Toogood, A.A., Frobisher, C., Lancashire, E.R., Winter, D.L., Kuehni, C.E., Hawkins, M.M. (2011) Health Care Utilization of Long-Term Survivors of Childhood Cancer: The British Childhood Cancer Survivor Study. J. Clin. Oncology, 29(31): 4181-4188

Haddy, N., Mousannif, A., Tukenova, M., Guibout, C., Grill, J., Dhermain. F., Pacquement, H., Oberlin, O., El-Fayech, C., Rubino, C., Thomas-Teinturier, C., Le-Deley, M-C., Hawkins, M., Winter, D., Chavaudra, J., Diallo, I., de Vathaire, F. (2011) Relationship between the brain radiation dose for the treatment of childhood cancer and the risk of long-term cerebrovascular mortality. Brain, 134: 1362-1372.

Reulen, R.C., Frobisher, C., Winter, D.L., Kelly, J.S., Lancashire, E.R., Stiller, C.A., Pritchard-Jones, K., Jenkinson, H.C., Hawkins, M.M. (2011) Long-term Risks of Subsequent Primary Neoplasms Among Survivors of Childhood Cancer. JAMA., 305(22): 2311-2319.

Tukenova, M., Guibout, C., Hawkins, M., Quiniou, E., Mousannif, A., Pacquement, H., Winter, D., Bridier, A., Lefkopoulos, D., Oberlin, O., Diallo, I., de Vathaire, F. (2011) Radiation therapy and late mortality from second sarcoma, carcinoma and hematological malignancies after a solid cancer in childhood. Int. J. Radiation Oncology Biol. Phys., 80(2): 339-46.

Taylor, A.J., Little, M.P., Winter, D.L., Sugden, E., Ellison, D.W., Stiller, C.A., Stovall, M., Frobisher, C., Lancashire, E.R., Reulen, R.C., Hawkins, M.M., on behalf of the British Childhood Cancer Survivor Study. (2010) Population-based risks of central nervous system tumours in childhood cancer survivors: the British Childhood Cancer Survivor Study. J. Clin. Oncology, 28(36): 5287-93.

Frobisher, C., Gurung, P.M.S., Leiper, A., Reulen, R.C., Winter, D.L., Taylor, A.J., Lancashire, E.R., Woodhouse, C.R.J., Hawkins, M.M. (2010) Risk of bladder tumours after childhood cancer: The British Childhood Cancer Survivor Study (BCCSS). BJU Int., 106(7): 1060-1069.

Reulen, R.C., Winter, D.L., Frobisher, C., Lancashire, E.R., Stiller, C.A., Jenney, M.E., Skinner, R., Stevens, M.C., Hawkins, M.M. (2010) Long-term Cause-specific Mortality among Survivors of Childhood Cancer. JAMA., 304(2): 172-179