Dr Rebecca Whittle PhD, MSc, BSc

Dr Rebecca Whittle

Research Fellow in Biostatistics

Contact details

Address
Public Health Building
University of Birmingham
Edgbaston
Birmingham

Rebecca is a medical statistician based in the BESTEAM research group. Her main research interests lie in prognosis and prediction, with a focus on improving the reporting and development of prediction modelling. Rebecca has also been involved in many applied health research projects, mainly using large data from electronic health records. 

ORCiD: 0000-0003-1793-0135

ResearchGate profile

Qualifications

  • PhD “Statistical methods for prognostic factor and risk prediction research”, Keele University, 2023
  • MSc in Medical Statistics, University of Leicester, 2013
  • BSc in Mathematics, University of Leeds, 2012

Biography

Rebecca completed her MSc in Medical Statistics at the University of Leicester in 2013 as part of a NIHR Research Methods Fellowship at Keele University.

Following completion of her MSc and the remainder of her fellowship at Keele, Rebecca began a PhD on a part time basis. The overarching focus of her thesis was to apply and develop statistical methods for prognosis research, with a particular focus on the identification of prognostic factors and the performance of risk prediction models. There was a particular emphasis on various methodological aspects relating to this, including the measurement error that may be present within predictors used in the development of prediction models, the impact of measuring a time-varying predictor after the intended moment of using the prediction model in practice, and the use of individual participant data (IPD) from multiple studies to evaluate prognostic factor effects with binary outcomes.

Whilst working towards her PhD, Rebecca also provided statistical support for various clinical research projects, with a particular focus on the use of large data from electronic health records.

Rebecca joined the BESTEAM research group at the University of Birmingham in November 2023 and is currently working on multiple projects to improve sample size calculations for the development, validation, and updating of clinical prediction models.

Research

Current projects

  • SS-PREDICT - Sample size guidance for developing and validation reliable and fair AI prediction models in healthcare.
  • SS-UPDATE - Sample size calculations for updating clinical prediction models to ensure their accuracy and fairness in practice.

Publications

Dhiman P, Ma J, Kirtley S, Mouka E, Waldron CM, Whittle R, Collins GS. (2024) Prediction model protocols indicate better adherence to recommended guidelines for study conduct and reporting. J Clin Epidemiol. doi: 10.1016/j.jclinepi.2024.111287

Collins GS, Whittle R, Bullock GS, Logullo P, Dhiman P, de Beyer JA, Riley RD, Schlussel MM. (2023) Open science practices need substantial improvement in prognostic model studies in oncology using machine learning. J Clin Epidemiol. doi: 10.1016/j.jclinepi.2023.10.015

Dhiman, P., Whittle, R., Van Calster, B. et al. (2023) The TRIPOD-P reporting guideline for improving the integrity and transparency of predictive analytics in healthcare through study protocols. Nat Mach Intell; 5: 816–817

Riley RD, Collins GS, Hattle M, Whittle R, Ensor J. (2023) Calculating the power of a planned individual participant data meta-analysis of randomised trials to examine a treatment-covariate interaction with a time-to-event outcome. Res Syn Meth; 14(5): 718-730. 

Riley RD, Hattle M, Collins GS, Whittle R, Ensor J. (2022) Calculating the power to examine treatment-covariate interactions when planning an individual participant data meta-analysis of randomized trials with a binary outcome. Statistics in Medicine; 41(24): 4822–4837

Richard D. Riley, Kym I.E. Snell, Glen P. Martin, Rebecca Whittle, Lucinda Archer, Matthew Sperrin, Gary S. Collins, (2021) Penalization and shrinkage methods produced unreliable clinical prediction models especially when sample size was small. J Clin Epidemiol; 132: 88-96,

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