Professor Natalie Rowland (née Ives) BSc (Hons), MSc

Mrs Natalie Rowland

Birmingham Clinical Trials Unit
Professor of Clinical Trials and Statistics
BCTU Director of Statistics and Research Strategy

Contact details

Address
Birmingham Clinical Trials Unit (BCTU)
College of Medicine and Health
Public Health Building
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Natalie Rowland (nee Ives) is a Professor of Clinical Trials and Statistics. She is a member of the Senior Leadership Team at the Birmingham Clinical Trials Unit (BCTU), where she is the BCTU Director of Statistics and Research Strategy.

Natalie’s primary interest is in the methodological design, conduct, analysis and delivery of clinical trials to improve evidence and change clinical practice to deliver better outcomes for patients.

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Qualifications

  • MSc in Statistics, University of Sheffield, 1997
  • BSc (Hons) in Mathematics (1st), University of Leicester, 1995

Biography

Natalie graduated from the University of Leicester in 1995 with a first class BSc (Hons) degree in Mathematics. After a gap year, she then went on to study for an MSc in Statistics at the University of Sheffield.

After finishing her Masters, Natalie started work as a Statistician within a HIV epidemiology research unit, first at Imperial College School of Medicine, London and then at King's College School of Medicine, London. In 2001, she joined the Birmingham Clinical Trials Unit (BCTU) at the University of Birmingham as a Medical Statistician.

Since arriving in Birmingham, she has progressed to Senior Statistician (since 2004) and was the Statistics Team Leader from March 2007 to September 2021 responsible for the management and oversight of the growing statistics team within BCTU.  Since September 2021, she has been the BCTU Director of Statistics and Research Strategy.  She was conferred the academic title of Professor of Clinical Trials and Statistics in August 2024.

Natalie’s primary interest is in the methodological design, conduct, analysis and delivery of clinical trials to improve evidence and change clinical practice to deliver better outcomes for patients.  She is the lead methodologist and senior statistician on a substantial and diverse portfolio of high quality clinical trials in a wide range of disease areas, including Inflammatory Bowel Disease, Coloproctology, Neuroscience and Parkinson’s disease, Renal Disease, Diabetes, Critical Care and Trauma.  The trials assess medical, surgical and complex interventions in both the Primary and Secondary care settings in both adults and children.

Natalie has built a substantial portfolio of externally funded clinical trial research (>£32 million), where she led on the methodological development of the research question, and has published over 100 peer-reviewed research publications, the majority in world-leading, high-impact general medical journals, such as the New England Journal of Medicine (NEJM), the Lancet, the Journal of the American Medical Association (JAMA), and the British Medical Journal (BMJ). 

Natalie has an interest in training and development, and in particular the training of clinical investigators of the future in the design, management and analysis of clinical trials.  She has developed a clinical trials “clerkship” for clinical investigators that combines a programme of training with hands-on experience, mentorship and access to experts working in clinical trials.  This Clinical Trials Unit based training provides fellows with a unique opportunity to learn about clinical trials through hands on experience in a highly active research environment.

Teaching

Teaching Programmes

Postgraduate supervision

Natalie is interested in supervising doctoral researchers in the following general research areas:

  • Randomised controlled trials including pilot and feasibility trials
  • Clinical trial methodology
  • Methods to improve the design and efficiency of clinical trials

Research

Natalie is interested in the methodological design, conduct, analysis and delivery of large scale late phase randomised controlled clinical trials.  She is the Lead Methodologist and Senior Statistician on a substantial and diverse portfolio of high quality clinical trials in the areas of Inflammatory Bowel Disease, Coloproctology, Neuroscience and Parkinson’s disease, Renal Disease, Diabetes, Critical Care and Trauma assessing medical, surgical and complex interventions in both the Primary and Secondary care settings in both adults and children. She is a co-applicant on a number of trials and has been awarded over £32 million of research funds, mainly from the National Institute for Health and Care Research (NIHR) who are the leading funder of clinical research in the UK, funded by the Department of Health.

Natalie's research has been published in various high impact scientific journals (NEJM, Lancet, BMJ).  She has over 100 peer-reviewed research publications.

Other activities

  • Advisor at the NIHR Research Support Service (RSS) delivered by the University of Birmingham and Partners
  • Member of the NIHR Undergraduate Internship Programme Selection Committee (2024 – present)
  • Member of the NIHR Incubator for Methodology (2020 - present), and lead for the Incubator Awareness Raising work stream
  • Member of the UKCRC Statistics Operational Group committee (2019 - present).
  • Reviewer for various scientific journals
  • Statistical reviewer for the NIHR (HTA, EME, RfPB)
  • Independent statistician on several Trial Steering and Data Monitoring Committees contributing to the oversight and direction of externally run clinical trials

Publications

Recent publications

Article

Price, J, Rushton, A, Ives, N, Jolly, K, Parmar, P & Greaves, C 2025, 'Co-designed neck exercise (EPIC-Neck) vs usual exercise care for people with chronic non-specific neck pain: protocol for a randomised feasibility study with process evaluation', Pilot and Feasibility Studies, vol. 11, no. 1, 26. https://doi.org/10.1186/s40814-025-01608-6

SUNRRISE Trial Study Group 2025, 'Negative Pressure Dressings to Prevent Surgical Site Infection After Emergency Laparotomy: The SUNRRISE Randomized Clinical Trial', JAMA. https://doi.org/10.1001/jama.2024.24764

Daley, AJ, Griffin, RA, Sanders, JP, Gokal, K, Ives, N, Skrybant, M, Parretti, H, Edwardson, CL, Biddle, SJH, Jolly, K, Greaves, C, Greenfield, SM, Maddison, R, Esliger, DW, Sherar, LB, Frew, E, Mutrie, N, Maylor, B, Yates, T, Tearne, S & Moakes, CA 2025, 'Snacktivity™ to promote physical activity in primary care, community health and public health settings: A feasibility randomised controlled trial ', International Journal of Behavioral Medicine. https://doi.org/10.1007/s12529-025-10352-3

Mathur, P, Thomas, H, Cooper, A, Chechlacz, M, Stathi, A, Goodyear, V, Miller, C, Krauss, T, Ives, N, Magill, L, Kinghorn, P, Wilson, D & Chiou, S-Y 2025, 'Supervised and self-directed technology-based dual-task exercise training programme for older adults at risk of falling - Protocol for a feasibility study', PLOS One, vol. 20, no. 3, pp. e0314829. https://doi.org/10.1371/journal.pone.0314829

Bilateral Remote Ischemic Conditioning in Children Trial Investigators, Drury, NE, Doorn, CV, Woolley, RL, Amos-Hirst, RJ, Bi, R, Spencer, CM, Morris, KP, Montgomerie, J, Stickley, J, Crucean, A, Gill, A, Hill, M, Weber, RJM, Najdekr, L, Jankevics, A, Southam, AD, Lloyd, GR, Jaber, O, Kassai, I, Pelella, G, Khan, NE, Botha, P, Barron, DJ, Madhani, M, Dunn, WB, Ives, NJ, Kirchhof, P & Jones, TJ 2024, 'Bilateral Remote Ischemic Conditioning in Children: a two-center, double-blind, randomized controlled trial in young children undergoing cardiac surgery', The Journal of Thoracic and Cardiovascular Surgery, vol. 18, pp. 193-208. https://doi.org/10.1016/j.xjon.2024.02.018

Spencer, S, Desborough, R, Mehta, S, Ives, N & Bhandari, S 2024, 'Cystatin C vs Creatinine eGFR in Advanced CKD: an analysis of the STOP-ACEi Trial ', Clinical Kidney Journal. https://doi.org/10.1093/ckj/sfae268

Ives, N, Woolley, R, Saleem , MA, Moakes, C, Waters, A, Gilbert, RD, Jarrett, H, Brettell, E, Nash, S, Farmer, LK, Ourradi, K & Johnson, SA 2024, 'Efficacy and safety of eculizumab in children with Shiga-toxin-producing Escherichia coli haemolytic uraemic syndrome: the ECUSTEC RCT', Efficacy and Mechanism Evaluation, vol. 11, no. 11, pp. 1-78. https://doi.org/10.3310/RFTY4766

Bhandari, S, Mehta, S, Khawaja, A, Cleland, JGF, Rowland, N & Cockwell, P 2024, 'Evaluation of the stopping angiotensin converting enzyme inhibitor compared to angiotensin receptor blocker (STOP ACEi trial) in advanced and progressive chronic kidney disease', Kidney International, vol. 105, no. 1, pp. 200-208. https://doi.org/10.1016/j.kint.2023.09.012

Adams, R, Jordan, R, Maher, A, Adab, P, Barrett, T, Bevan, S, Cooper, L, DuRand, I, Edwards, F, Hardy, P, Harris, C, Heneghan, NR, Jolly, K, Jowett, S, Marshall, T, O'Hara, M, Poyner, C, Rai, K, Rickards, H, Riley, R, Ives, N, Sadhra, S, Tearne, S, Walters, G & Sapey, E 2024, 'Health screening clinic to reduce absenteeism and presenteeism among NHS Staff: eTHOS a pilot RCT', Health and Social Care Delivery Research, vol. 12, no. 23, pp. 1-105. https://doi.org/10.3310/KDST3869

Sackley, CM, Rick, C, Brady, MC, Woolley, R, Burton, C, Patel, S, Masterson-Algar, P, Nicoll, A, Smith, CH, Jowett, S, Ives, N, Beaton, G, Dickson, S, Ottridge, R, Sharp, L, Nankervis, H, Clarke, CE & PD COMM Collaborative Group 2024, 'Lee Silverman voice treatment versus NHS speech and language therapy versus control for dysarthria in people with Parkinson’s disease (PD COMM): pragmatic, UK based, multicentre, three arm, parallel group, unblinded, randomised controlled trial', BMJ, vol. 386, e078341. https://doi.org/10.1136/bmj-2023-078341

Krouwel, M, Greenfield, S, Sanders, JP, Gokal, K, Chalkley, A, Griffin, RA, Parretti, H, Jolly, K, Skrybant, M, Biddle, S, Greaves, C, Esliger, DW, Sherar, LB, Edwardson, C, Yates, T, Maddison, R, Frew, E, Mutrie, N, Ives, N, Tearne, S & Daley, AJ 2024, 'Making Every Contact Count: health professionals' experiences of integrating conversations about Snacktivity to promote physical activity within routine consultations - a qualitative study', BMJ open, vol. 14, no. 10, e085233. https://doi.org/10.1136/bmjopen-2024-085233

Crombie, N, Doughty, HA, Bishop, JRB, Desai, A, Dixon, EF, Hancox, JM, Herbert, MJ, Leech, C, Lewis, SJ, Nash, MR, Naumann, DN, Piper, K, Slinn, G, Smith, H, Smith, IM, Wale, RK, Wilson, A, Crombie, A, Midwinter, M, Ives, N & Perkins, GD 2024, 'Resuscitation with pre-hospital blood products in adults with trauma-related haemorrhagic shock: the RePHILL RCT', Efficacy and Mechanism Evaluation, vol. 11, no. 2. https://doi.org/10.3310/TDNB9214

Abstract

Bhandari, S, Mehta, S, Ives, N & Cockwell, P 2024, 'WCN24-318: Utility of 2-year Kidney Failure Risk Equation for advanced chronic kidney disease: analysis from the STOP ACEi Trial', Kidney International Reports, vol. 9, no. 4, pp. S81-S82. https://doi.org/10.1016/j.ekir.2024.02.174

Spencer, S, Desborough, R, Mehta, S, Rowland, N & Bhandari, S 2024, 'WCN24-398: Report on STOP-ACEi trial: reviewing cystatin C levels in CKD patients', Kidney International Reports, vol. 9, no. 4, pp. S83-S83. https://doi.org/10.1016/j.ekir.2024.02.176

Letter

Bhandari, S, Mehta, S, Rowland, N & Cockwell, P 2024, 'Utility of 2-year kidney failure risk equation for advanced chronic kidney disease: analysis from the STOP-ACEi trial', Nephrology, Dialysis, Transplantation, vol. 39, no. 5, pp. 884–887. https://doi.org/10.1093/ndt/gfad263

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