Recent publications
Article
Leung, EYL, Robbins, HL, Zaman, S, Lal, N, Morton, D, Dew, L, Williams, AP, Wallis, Y, Bell, J, Raghavan, M, Middleton, G & Beggs, AD 2024, 'The potential clinical utility of Whole Genome Sequencing for patients with cancer: evaluation of a regional implementation of the 100,000 Genomes Project', British Journal of Cancer, vol. 131, no. 11, pp. 1805-1813. https://doi.org/10.1038/s41416-024-02890-6
Pickles, OJ, Wanigasooriya, K, Ptasinska, A, Patel, AJ, Robbins, HL, Bryer, C, Whalley, CM, Tee, L, Lal, N, Pinna, M, Elzefzafy, N, Taniere, P, Beggs, AD & Middleton, GM 2023, 'MHC Class II is Induced by IFNγ and Follows Three Distinct Patterns of Expression in Colorectal Cancer Organoids', Cancer Research Communications, vol. 3, no. 8, pp. 1501-1513. https://doi.org/10.1158/2767-9764.CRC-23-0091
The LFD AI Consortium 2022, 'Machine learning for determining lateral flow device results for testing of SARS-CoV-2 infection in asymptomatic populations', Cell Reports Medicine, vol. 3, no. 10, 100784. https://doi.org/10.1016/j.xcrm.2022.100784
Wanigasooriya, K, Sarma, D, Woods, P, O’connor, P, Matthews, A, Aslam, M, Dando, C, Ferguson, H, Francombe, J, Lal, N, Murphy, P, Papettas, T, Ramcharan, S & Busby, K 2022, 'The benefits of index telephone consultations in patients referred on the two-week wait colorectal cancer pathway', Annals of the Royal College of Surgeons of England. https://doi.org/10.1308/rcsann.2021.0364
Cragg, J, Mushtaq, F, Lal, N, Garnham, A, Hallissey, M, Graham, T & Shiralkar, U 2021, 'Surgical cognitive simulation improves real-world surgical performance: randomized study', BJS Open, vol. 5, no. 3, zrab003. https://doi.org/10.1093/bjsopen/zrab003
RIFT Study Group on behalf of the West Midlands Research Collaborative & Morton, D 2020, 'Appendicitis risk prediction models in children presenting with right iliac fossa pain (RIFT study): a prospective, multicentre validation study', The Lancet Child & Adolescent Health. https://doi.org/10.1016/s2352-4642(20)30006-7
Brooks, J, Antao Mobre De Menezes, ARE, Ibrahim, M, Archer, L, Lal, N, Bagnall, C, Zeidler, SVV, Valentine, H, Spruce, R, Batis, N, Bryant, J, Hartley, M, Kaul, B, Ryan, G, Bao, R, Khattri, A, Lee, S, Ogbureke, KUE, Middleton, G, Tennant, D, Beggs, A, Deeks, J, West, CML, Cazier, J-B, Willcox, B, Seiwert, TY & Mehanna, H 2019, 'Development and validation of a combined hypoxia and immune prognostic classifier for head and neck cancer', Clinical Cancer Research, vol. 25, no. 17, pp. 5315-5328. https://doi.org/10.1158/1078-0432.CCR-18-3314, https://doi.org/10.1158/1078-0432.CCR-18-3314
Horniblow, RD, Bedford, M, Hollingworth, R, Evans, S, Sutton, E, Lal, N, Beggs, A, Iqbal, TH & Tselepis, C 2017, 'B-RAF mutations are associated with increased iron regulatory protein-2 expression in colorectal tumourigenesis', Cancer Science. https://doi.org/10.1111/cas.13234
Lal, N, Willcox, C, Beggs, A, Taniere, P, Middleton, G, Tselepis, C & Willcox, B 2017, 'Endothelial protein C receptor is overexpressed in colorectal cancer as a result of amplification and hypomethylation of chromosome 20q', Journal of Pathology: Clinical Research, vol. 3, no. 3, pp. 155–170. https://doi.org/10.1002/cjp2.70
Lal, N, White, BS, Goussous, G, Pickles, OJ, Mason, M, Beggs, AD, Taniere, P, Willcox, BE, Guinney, J & Middleton, G 2017, 'KRAS mutation and Consensus Molecular Subtypes 2 and 3 are independently associated with reduced immune infiltration and reactivity in colorectal cancer', Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-17-1090
Pachnio, A, Ciaurriz, M, Begum, J, Lal, N, Zuo, J, Beggs, A & Moss, P 2016, 'Cytomegalovirus infection leads to development of high frequencies of cytotoxic virus-specific CD4+ T Cells targeted to vascular endothelium', PLoS pathogens, vol. 12, no. 9, e1005832. https://doi.org/10.1371/journal.ppat.1005832
Lal, N, Beggs, AD, Willcox, BE & Middleton, GW 2015, 'An immunogenomic stratification of colorectal cancer : implications for development of targeted immunotherapy', OncoImmunology, vol. 4, no. 3, e976052. https://doi.org/10.4161/2162402X.2014.976052
Bhangu, A, Nepogodiev, D, Lal, N & Bowley, DM 2012, 'Meta-analysis of predictive factors and outcomes for failure of non-operative management of blunt splenic trauma', Injury, vol. 43, no. 9, pp. 1337-1346. https://doi.org/10.1016/j.injury.2011.09.010
Lal, N, Singh, P, Sellahewa, C & Patel, R 2012, 'Mortality following Hartmann's procedure – correlation of Dr. Foster's report with CR-POSSUM', International journal of surgery (London, England), vol. 10, no. 9, pp. 480-483. https://doi.org/10.1016/j.ijsu.2012.06.004
Abstract
Mehanna, HM, Brooks, J, Menezes, A, Ibrahim, M, Lal, N, Archer, L, Zeidler, SV, Bao, R, Khattri, A, Valentine, H, Spruce, R, Batis, N, Bryant, J, Beggs, AD, Tennant, D, West, C, Middleton, GW, Cazier, J-B, Willcox, B & Seiwert, TY 2018, 'Development and validation of a combined metabolic and immune prognostic classifier for head and neck cancer', Journal of Clinical Oncology, vol. 36, no. 15 Suppl, pp. 6049-6049. https://doi.org/10.1200/jco.2018.36.15_suppl.6049
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