Overview
The aim of this microcredential is to prepare students to understand the role of genetics in disease, how genomic information can be utilised to elucidate disease mechanism and biology, and its role in personalised medicine. This microcredential will serve as a foundation for those wishing to advance their careers within the NHS in genomic medicine.
This microcredential will cover the structure and variations in the human genomics, including fundamental principles of genetics and genomics. Students undertaking this module will review the architecture of the human genome and the functional units embedded in it. In addition this module will cover DNA sequence variation and how variation is structured across the genome explaining the principles of linkage disequilibrium and its extent in human populations (e.g. HapMap project). Students will also cover aspects of gene regulation and chromatin structure and understand the importance of genotype to phenotype correlation.
Module content
- Structure and organisation of the human genome and genetic variation within it.
- Overview of DNA replication, transcription and translation.
- Overview of cell division (mitosis, meiosis) and recombination.
- Gene regulation: enhancers, promoters, transcription factors, silencers and the role of epigenetics.
- DNA sequence variation, type and frequency, for example, single nucleotide variants (SNVs), small insertions and deletions (indels), copy number variation (CNVs), rearrangements and tandem repeats.
- How variation arises and its extent in populations.
- Concept of Hardy-Weinberg equilibrium
- Mutational mechanisms: how different types of DNA variants (including epigenetics and imprinting) affect gene function or expression to cause disease.
- Correlation of genotype with phenotype, including penetrance and variation in expression.
- Concepts of heterogeneity and pleiotropy.
- Modes of inheritance for clinical manifestation of human variation.
Credits
15 Masters level credits
Attendance required
On campus teaching will be delivered over 5 days: Monday 23rd, Tuesday 24th, Friday 27th, Monday 30th September and Friday 4th October 2024.
Module Leads
Professor Ferenc Müller (Professor of Developmental Genetics, Department of Cancer and Genomic Sciences).
Dr Richard Tuxworth (Senior Lecturer, Department of Cancer and Genomic Sciences)
Prerequisites
To apply, students should have a good honours degree in a life sciences subject, although we will consider applicants with alternative qualifications and professional experience within the health service or other relevant background.
Please contact the Programme Coordinator for further information at genomics@contacts.bham.ac.uk
Please note this microcredential is available for home applicants only.
Why choose a Postgraduate Microcredential short course?
- Usually taken from exisiting modules within a Masters, they can be used as standalone credentials with some also counting as academic credits at postgraduate level
- Add a postgraduate level qualification to your CV
- Develop the specialist skills you need for your career goals
- Alumni status with the University of Birmingham
- Learners will have the same access to our student support and campus facilities as our students on full degree programmes.
Apply for the Microcredential