Recent publications
Article
Innovative Therapies for Children with Cancer (ITCC) Consortium & European Association for Neuroblastoma Research (SIOPEN) 2024, 'Bevacizumab, Irinotecan, or Topotecan Added to Temozolomide for Children With Relapsed and Refractory Neuroblastoma: Results of the ITCC-SIOPEN BEACON-Neuroblastoma Trial', Journal of Clinical Oncology. https://doi.org/10.1200/JCO.23.00458
Syrimi, E, Khan, N, Murray, P, Willcox, C, Haigh, T, Willcox, B, Masand, N, Bowen, C, Dimakou, DB, Zuo, J, Barone, SM, Irish, JM, Kearns, P & Taylor, GS 2024, 'Defects in NK cell immunity of pediatric cancer patients revealed by deep immune profiling', iScience. https://doi.org/10.1016/j.isci.2024.110837
Innovative Therapies for Children with Cancer (ITCC) Consortium 2024, 'Evolution of the Innovative Therapies for Children With Cancer Consortium Trial Portfolio for Drug Development for Children With Cancer', Journal of Clinical Oncology , pp. JCO2301237. https://doi.org/10.1200/JCO.23.01237
Chisholm, J, Mandeville, H, Adams, M, Minard-Collin, V, Rogers, T, Kelsey, A, Shipley, J, van Rijn, RR, de Vries, I, van Ewijk, R, de Keizer, B, Gatz, SA, Casanova, M, Hjalgrim, LL, Firth, C, Wheatley, K, Kearns, P, Liu, W, Kirkham, A, Rees, H, Bisogno, G, Wasti, A, Wakeling, S, Heenen, D, Tweddle, DA, Merks, JHM, Jenney, M & Heymann, D (ed.) 2024, 'Frontline and Relapsed Rhabdomyosarcoma (FAR-RMS) Clinical Trial: A Report from the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG)', Cancers, vol. 16, no. 5, 998. https://doi.org/10.3390/cancers16050998
OCTAVE-DUO investigators & Parry, H 2024, 'Immunogenicity of third dose COVID-19 vaccine strategies in patients who are immunocompromised with suboptimal immunity following two doses (OCTAVE-DUO): an open-label, multicentre, randomised, controlled, phase 3 trial', The Lancet Rheumatology, vol. 6, no. 6, pp. E339-E351. https://doi.org/10.1016/S2665-9913(24)00065-1
Perry, TA, Masand, N, Vrzalikova, K, Pugh, M, Wei, W, Hollows, R, Bouchalova, K, Nohtani, M, Fennell, E, Bouchal, J, Kearns, P & Murray, PG 2024, 'The Oncogenic Lipid Sphingosine-1-Phosphate Impedes the Phagocytosis of Tumor Cells by M1 Macrophages in Diffuse Large B Cell Lymphoma', Cancers, vol. 16, no. 3, 574. https://doi.org/10.3390/cancers16030574
Janssens, GO, Timmermann, B, Laprie, A, Mandeville, H, Padovani, L, Chargari, C, Kearns, P, Kozhaeva, O, Kameric, L, Kienesberger, A, van Rossum, PSN, Boterberg, T, Lievens, Y & Vassal, G 2024, 'The organization of care in pediatric radiotherapy across SIOP Europe affiliated centers: A multicenter survey in the framework of the 'Joint Action on Rare Cancers' project', Radiotherapy & Oncology, vol. 191, 110075. https://doi.org/10.1016/j.radonc.2023.110075
Experimental Cancer Medicine Centres (ECMC) CID trials working group, Blagden, SP, Yu, L-M, Ellis, S, Hughes, H, Shaaban, A, Fennelly-Barnwell, J, Lythgoe, MP, Cooper, AM, Maignen, FM, Buckland, SW, Kearns, PR & Brown, LC 2023, 'Additional consensus recommendations for conducting complex innovative trials of oncology agents: a post-pandemic perspective', British Journal of Cancer, vol. 128, no. 3, pp. 474-477. https://doi.org/10.1038/s41416-022-02051-7
de Rojas, T, Kearns, P, Blanc, P, Skolnik, J, Fox, E, Knox, L, Rousseau, R, Doz, F, Bird, N, Pearson, AJ & Vassal, G 2023, 'Changing incentives to ACCELERATE drug development for paediatric cancer', Cancer Medicine, vol. 12, no. 7, pp. 8825-8837. https://doi.org/10.1002/cam4.5627
Moreno, L, DuBois, SG, Glade Bender, J, Mauguen, A, Bird, N, Buenger, V, Casanova, M, Doz, F, Fox, E, Gore, L, Hawkins, DS, Izraeli, S, Jones, DTW, Kearns, PR, Molenaar, JJ, Nysom, K, Pfister, S, Reaman, G, Smith, M, Weigel, B, Vassal, G, Zwaan, CM, Paoletti, X, Iasonos, A & Pearson, ADJ 2023, 'Combination Early-Phase Trials of Anticancer Agents in Children and Adolescents', Journal of Clinical Oncology . https://doi.org/10.1200/JCO.22.02430
Abstract
Seaford, E, Maycock, S, Alexander, S, Beishuizen, A, Wistinghausen, B, Minard-Colin, V, Rigaud, C, Phillips, CA, Ford, JB, Kearns, PR, Lawson, A, Williams, E, Ahmed, Z, Muzaffar, M, Parsons, R, Gore, L, Scobie, N, Buenger, V, Allen, C, Mellgren, K, Bollard, CM, Auperin, A, Billingham, L & Burke, GAA 2023, 'A Global Study of Novel Agents in Paediatric and Adolescent Relapsed and Refractory B-Cell Non-Hodgkin Lymphoma (Glo-BNHL)', Blood, vol. 142, no. Supplement 1, 3097. https://doi.org/10.1182/blood-2023-178658
Seaford, E, Scobie, N, Gore, L, Alexander, S, Beishuizen, A, Wistinghausen, B, Minard-Colin, V, Bollard, CM, Mellgren, K, Allen, C, Auperin, A, Buenger, V, Kearns, PR, Lawson, A, Williams, E, Maycock, S, Ahmed, Z, Muzaffar, M, Parsons, R, Billingham, L & Burke, GAA 2023, 'A Potential Paradigm for the Robust and Systematic Prioritisation of Assets in Academic-Led, Multi-Industry Collaborative Trials in Rare Populations (Glo-BNHL)', Blood, vol. 142, no. Supplement 1, 6247. https://doi.org/10.1182/blood-2023-178724
Comment/debate
Wilson, JS, Main, C, Thorp, N, Taylor, RE, Majothi, S, Kearns, PR, English, M, Dandapani, M, Phillips, R, Wheatley, K & Pizer, B 2024, 'Correction to: The effectiveness and safety of proton beam radiation therapy in children and young adults with Central Nervous System (CNS) tumours: a systematic review', Journal of Neuro-Oncology. https://doi.org/10.1007/s11060-024-04612-7
Letter
Joy, M, Enshaei, A, Kirkwood, A, Kearns, PR, Samarasinghe, S, Moppett, J, Moorman, AV, Vora, A & Connor, DO 2023, 'Cranial radiotherapy has minimal benefit in children with central nervous system involvement in T-ALL', Blood Advances. https://doi.org/10.1182/bloodadvances.2023011267
Review article
Wilson, JS, Main, C, Thorp, N, Taylor, RE, Majothi, S, Kearns, PR, English, M, Dandapani, M, Phillips, R, Wheatley, K & Pizer, B 2024, 'The effectiveness and safety of proton beam radiation therapy in children and young adults with Central Nervous System (CNS) tumours: a systematic review', Journal of Neuro-Oncology. https://doi.org/10.1007/s11060-023-04510-4
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