Welcome to ModNanoTox
ModNanoTox is a FP7 funded project, which started in November 2011. The project aims to develop a number of well-documented and technically advanced models describing the behaviour of engineered nanoparticles in an environmental or biological context to comprehensively address the following key hypotheses:
- Toxicity of nanoparticles is the result of physicochemical properties and this has been documented reliably in completed/ongoing datasets. Properties found to be relevant include size, surface area, structure and composition
- Nanoparticle reactivity can be modelled computationally and can be linked to toxicity
- Toxic responses from cell culture studies and whole organisms can be correlated and rationalised and can be translated into tools useful for model development
- Bioaccumulation into cells or whole organisms can be characterized and modelled using biodynamic principles (i.e. by characterizing uptake rate constants from food and water as well as loss rate constants)
- Toxic responses from cell culture studies and whole organisms can be modelled reliably by QSAR type approaches
- Exposure concentrations can be assessed reliably and incorporated in appropriate models
- Ecological effect models can be developed by extrapolation from (eco)toxicological observations and can be built into risk assessment models