Professor Greaves has helped to develop and evaluate intervention programmes to support people in losing weight and reducing disease risk through changes in diet and physical activity (Waste the Waist, eCOACHER, WAKEUP, Norfolk Diabetes Prevention Study, ImpulsePal, ComPoD), stopping smoking (EARS, TARS), improving self-care of heart failure (REACH-HF, REACH-HFpEF, D-REACH-HF), reducing the decline of physical functioning in ageing (REACT, ACE), managing depression (eMotion), reducing cardiovascular risk (CRISP) and multimorbidity rehabilitation (PERFORM). He has a strong interest in research to better understand the processes of behaviour change in behavioural interventions using both qualitative and quantitative methods. His systematic reviews of "what works for supporting changes in diet and physical activity" and “diabetes prevention in the real world” have informed a European evidence-based guideline (IMAGE) and NICE guidance on the prevention of diabetes, as well as the development of the English National Diabetes Prevention Programme.
He has ongoing interests in health behaviour change and in translating technical knowledge on physiology and nutrition into pragmatic interventions that can improve the wellbeing and health of people with long term illnesses.