Eales K.L, Wilkinson E.A, Cruickshank G.S, Tucker J.H.R and Tennant D.A. (2018) Verteporfin selectively kills hypoxic glioma through iron-binding and increased production of reactive oxygen species. Sci Rep. 8(1):14358
Hollinshead K.E.R, Munford H, Eales K.L , Bardella C, Li C, Escribano-Gonzalez C, Thakker A, Nonnenmacher Y, Kluckova K, Jeeves M, Murren R, Cuozzo F, Ye D, Laurenti G, Zhu W, Hiller K, Hodson D.J, Hua W, Tomlinson I.P, Ludwig C, Mao Y, Tennant D.A. (2018) Oncogenic IDH1 mutations promote enhanced proline synthesis through pycr1 to support the maintenance of mitochondrial redox homeostasis. Cell Reports 22(12), 3107
Kluckova K and Tennant D.A. (2018). Metabolic implications of hypoxia and pseudohypoxia in pheochromocytoma and parganglioma. Cell Tissue Res 1-12
Bennett C.D, Kohe S.E, Gill S.K, Davies N.P, Wilson M, Storer L.C.D, Ritzmann T, Paine S.M.L, Scott I.S, Nicklaus-Wollenteit I, Tennant D.A, Grundy R.G, Peet A.C (2018). Tissue metabolite profiles for the characterisation of paediatric cerebellar tumours. Sci Rep. 8(1):11992
Chong M, Jayaraman A, Marin S, Slivanov P.R, de Atauri Carulla P.R, Tennant D.A, Cascante M, Günther U.L, Ludwig C. (2017) Combined analysis of NMR and MS spectra (CANMS). Angew Chem Int Ed Engl. 56(15), 4140
McNee G, Williams D.S, Wenbin W, Barkhuisen A, Bartlett D.B, Essex S, Anandram S, Filer A, Moss P.A.H, Pratt, G, Basu S, Davies C.C, Tennant, D.A (2017) Citrullination of histone H3 drives IL-6 production by bone marrow mesenchymal stem cells in MGUS and multiple myeloma. Leukemia. 31(2), 373. Commentary in Lancet Oncology news section.
Laurenti G and Tennant D.A (2016) Isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH), fumarate hydratase (FH): three players for one phenotype in cancer? Biochemical Society Transactions. 44 (4), 1111-1116
Eales K.L, Hollinshead K.E, Tennant D.A (2016) Hypoxia and metabolic adaptation of cancer cells. Oncogenesis. Jan 25;5:e190. doi: 10.1038/oncsis.2015.50
Lussey-Lepoutre C, Hollinshead K.E, Ludwig C, Menara M, Morin A, Castro-Vega L.J, Parker SJ, Janin M, Martinelli C, Ottolenghi C, Metallo C, Gimenez-Roqueplo A.P, Favier J, Tennant D.A (2015) Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism. Nature Communocations. Nov 2;6:8784. doi: 10.1038/ncomms9784.
Ludwig C, Williams D.S, Bartlett D.B, Essex S, McNee G, Allwood J.W, Jewell E, Barkhuisen A, Parry H, Basu S, Dunn W.B, Moss P.A.H, Pratt G and Tennant D.A (2015) Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma. Blood Cancer Journal, 5:e359
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