Professor Adam Croft BSc (Hons), MBChB, PhD, MRCP (UK)

Adam Croft

Department of Inflammation and Ageing
Head of Department of Inflammation and Ageing
Professor of Translational Rheumatology
Kennedy Trust for Rheumatology Research Senior Clinical Research Fellow, Versus Arthritis Chair of Rheumatology

Contact details

Telephone
+44 (0)121 3713266
Email
a.p.croft@bham.ac.uk
Twitter
@APCroft
View my research portal
Address
Rheumatology Research Group
Department of Inflammation and Ageing
University of Birmingham
Queen Elizabeth Hospital, Birmingham, B15 2WB

Adam is Head of Department of Inflammation and Ageing, a multidisciplinary research department of discovery scientists and clinicians, translating mechanisms which underpin inflammation into new treatments/pathways for inflammatory diseases. Adam is also a Professor of Translational Rheumatology and an Honorary Consultant Rheumatologist at Sandwell and West Birmingham Hospitals and University Hospital of Birmingham NHS Trusts. He is also the Versus Arthritis Chair of Rheumatology. 

His main research interest is the development of novel immunotherapies for patients with autoimmune rheumatic and chronic inflammatory diseases, with a particular interest in the development of stromal cell (fibroblast) specific targets. He has received funding from the Wellcome Trust and NIHR.

His clinical interests include management of both early and treatment resistant inflammatory arthritis. His research is supported by the Kennedy Trust for Rheumatology Research, Versus Arthritis and Wellcome Trust.

Qualifications

  • PG Cert Medical education 2018
  • PG Cert in Clinical Research Methodology 2015
  • MRCP (UK) 2012
  • MBChB 2009
  • PhD 2005
  • BSc (Hons) 2002

Teaching

  • Year 2 BMedSci Immunology tutorials

Postgraduate supervision

Dr Croft's main research interest is in the development of novel immunotherapies for patients with autoimmune rheumatic and chronic inflammatory diseases. He has a particular interest in the development of stromal cell specific targets. His clinical interests include management of both early and treatment resistant inflammatory arthritis. He is also interested in the management of rare systemic inflammatory diseases including vasculitis.

PhD opportunites are available within the Rheumatology Research Group

Other activities

Current

  • 2018- Member of Paediatric and adolescent rheumatology network
  • 2018- Member of Scientific Advisory Committee, NIHR Wellcome Trust Clinical Research facility, University of Birmingham
  • 2016- UK country liaison to EMUNET EULAR advisory group (by competitive national appointment)
  • 2016- Member of West Midlands regional vasculitis network

Previous

  • 2015-2018 Chair of British Rheumatologists in Training Advisory Group and West Midlands regional representative (by competitive national appointment)
  • Member of British Society of Rheumatology Council
  • Member of Joint Specialty Committee at Royal College of Physicians
  • Member of rheumatology JRCTPB speciality advisory group
  • Member of Education and training subcommittee
  • 2016-2018 Member of Clinical Care Quality committee, British Society of Rheumatology (trainee representative)
  • 2016-2018 Member of Peer Review working group, British Society of Rheumatology (trainee representative)
  • 2013-2017 Royal college of Physicians Associate Clinical Tutor, Queen Elizabeth Hospital, Birmingham
  • 2012-2014 Associate Clinical Teaching Fellow, Queen Elizabeth Hospital, Birmingham
  • 2009-2013 Advanced Life Support Instructor, Resuscitation Council UK     

Publications

Recent publications

Article

Rauber, S, Mohammadian, H, Schmidkonz, C, Atzinger, A, Soare, A, Treutlein, C, Kemble, S, Mahony, CB, Geisthoff, M, Angeli, MR, Raimondo, MG, Xu, C, Yang, K-T, Lu, L, Labinsky, H, Saad, MSA, Gwellem, CA, Chang, J, Huang, K, Kampylafka, E, Knitza, J, Bilyy, R, Distler, JHW, Hanlon, MM, Fearon, U, Veale, DJ, Roemer, FW, Bäuerle, T, Maric, HM, Maschauer, S, Ekici, AB, Buckley, CD, Croft, AP, Kuwert, T, Prante, O, Cañete, JD, Schett, G & Ramming, A 2024, 'CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis', Nature Immunology. https://doi.org/10.1038/s41590-024-01774-4

Baruah, P, Mahony, C, Marshall, JL, Smith, CG, Monksfield, P, Irving, RI, Dumitriu, IE, Buckley, CD & Croft, AP 2024, 'Single-cell RNA sequencing analysis of vestibular schwannoma reveals functionally distinct macrophage subsets', British Journal of Cancer, vol. 130, no. 10, pp. 1659-1669. https://doi.org/10.1038/s41416-024-02646-2

Murillo-Saich, JD, Coras, R, Ramirez, J, Quesada-Masachs, E, Sala-Climent, M, Eschelbach, K, Mahony, CB, Celis, R, Armando, A, Quehenberger, O, Croft, AP, Kavanaugh, A, Chang, E, Cañete, JD, Guma, M & Singh, A 2024, 'Synovial 5-LOX-derived oxylipins define a lympho-myeloid-enriched synovium', Arthritis & Rheumatology (Hoboken). https://doi.org/10.1002/art.42848

Ahmed, S, Mahony, CB, Torres, A, Murillo-Saich, J, Kemble, S, Cedeno, M, John, P, Bhatti, A, Croft, AP & Guma, M 2023, 'Dual inhibition of glycolysis and glutaminolysis for synergistic therapy of rheumatoid arthritis', Arthritis Research & Therapy, vol. 25, no. 1, 176. https://doi.org/10.1186/s13075-023-03161-0

Khan, AO, Rodriguez-Romera, A, Reyat, JS, Olijnik, AA, Colombo, M, Wang, G, Wen, WX, Sousos, N, Murphy, LC, Grygielska, B, Perrella, G, Mahony, CB, Ling, RE, Elliott, NE, Karali, CS, Stone, AP, Kemble, S, Cutler, EA, Fielding, AK, Croft, AP, Bassett, D, Poologasundarampillai, G, Roy, A, Gooding, S, Rayes, J, Machlus, KR & Psaila, B 2023, 'Human Bone Marrow Organoids for Disease Modeling, Discovery, and Validation of Therapeutic Targets in Hematologic Malignancies', Cancer Discovery, vol. 13, no. 2, pp. 364-385. https://doi.org/10.1158/2159-8290.CD-22-0199

Reyat, JS, di Maio, A, Grygielska, B, Pike, J, Kemble, S, Rodriguez-Romero, A, Simoglou Karali, C, Croft, AP, Psaila, B, Simões, F, Rayes, J & Khan, AO 2023, 'Modelling the pathology and treatment of cardiac fibrosis in vascularised atrial and ventricular cardiac microtissues', Frontiers in cardiovascular medicine, vol. 10. https://doi.org/10.3389/fcvm.2023.1156759

Torres, A, Kang, S, Mahony, CB, Cedeño, M, Oliveira, PG, Fernandez-Bustamante, M, Kemble, S, Laragione, T, Gulko, PS, Croft, AP, Sanchez-Lopez, E, Miyamoto, S & Guma, M 2023, 'Role of mitochondria-bound HK2 in rheumatoid arthritis fibroblast-like synoviocytes', Frontiers in immunology, vol. 14, 1103231. https://doi.org/10.3389/fimmu.2023.1103231

Korsunsky, I, Wei, K, Pohin, M, Kim, EY, Barone, F, Major, T, Taylor, E, Ravindran, R, Kemble, S, Watts, GFM, Jonsson, AH, Jeong, Y, Athar, H, Windell, D, Kang, JB, Friedrich, M, Turner, J, Nayar, S, Fisher, BA, Raza, K, Marshall, JL, Croft, AP, Tamura, T, Sholl, LM, Vivero, M, Rosas, IO, Bowman, SJ, Coles, M, Frei, AP, Lassen, K, Filer, A, Powrie, F, Buckley, CD, Brenner, MB & Raychaudhuri, S 2022, 'Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases', Med, vol. 3, no. 7, pp. 481-518. https://doi.org/10.1016/j.medj.2022.05.002

Fenton, C, Martin, C, Jones, R, Croft, A, Campos, J, Naylor, A, Taylor, A, Chimen, M, Cooper, M, Lavery, G, Raza, K & Hardy, R 2021, 'Local steroid activation is a critical mediator of the anti-inflammatory actions of therapeutic glucocorticoids', Annals of the Rheumatic Diseases, vol. 80, no. 2, pp. 250-260. https://doi.org/10.1136/annrheumdis-2020-218493

Comment/debate

Bolton, C & Croft, AP 2024, 'All fibroblasts are equal, but some are more equal than others', Nature Reviews Rheumatology. https://doi.org/10.1038/s41584-024-01097-6

Hackland, A & Croft, AP 2023, 'Are the origins of adult arthritis seeded during embryonic development?', Nature Reviews Rheumatology, vol. 19, no. 3, pp. 132-133. https://doi.org/10.1038/s41584-023-00911-x

Editorial

Alegria, GC & Croft, AP 2022, 'Fibroblasts, a target for imaging and therapeutics in rheumatoid arthritis', Rheumatology, vol. 61, no. 7. https://doi.org/10.1093/rheumatology/keab845

Review article

CLUSTER Consortium, Wedderburn, LR, Ramanan, AV, Croft, AP, Hyrich, KL & Dick, AD 2022, 'Towards molecular-pathology informed clinical trials in childhood arthritis to achieve precision medicine in juvenile idiopathic arthritis', Annals of the Rheumatic Diseases. https://doi.org/10.1136/ard-2022-222553

Kemble, S & Croft, AP 2021, 'Critical Role of Synovial Tissue-Resident Macrophage and Fibroblast Subsets in the Persistence of Joint Inflammation', Frontiers in immunology, vol. 12, 715894. https://doi.org/10.3389/fimmu.2021.715894

Marsh, L-J, Kemble, S, Reis Nisa, P, Singh, R & Croft, AP 2021, 'Fibroblast pathology in inflammatory joint disease', Immunological Reviews, vol. 302, no. 1, pp. 163-183. https://doi.org/10.1111/imr.12986

View all publications in research portal