Professor Patricia Lalor (Trish) PhD, BSc

Department of Immunology and Immunotherapy
Professor in Experimental Hepatology

Contact details

Telephone: +44 (0)121 414 6967
Email: p.f.lalor@bham.ac.uk
Twitter: @BirminghamLiver

Address: Centre for Liver and Gastroenterology Research
Institute of Biomedical Research
Institute of Immunology and Immunotherapy
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Professor Lalor is a Senior Investigator in the Centre for Liver and Gastroenterology Research and an Academic with roles as a tutor and module lead on courses within the Medical School. Trish has a research group studying the molecular regulation of human liver disease and supervise postgraduate students and fellows working in this area and related cross-disciplinary schemes.

Professor Lalor is also Training Lead for the NIHR Birmingham Biomedical Research Centre.

Qualifications

Fellow of the Higher Education Academy
Postgraduate Certificate in Academic Practice (2014)
Foundation of Learning and Teaching in Higher Education, 2012
PhD in Immunology, 1998
BSc Hons Applied Biology, 1994

Biography

Professor Lalor's undergraduate degree included a year in research hosted in the laboratory of Professor Nash which developed her interest in the processes of inflammatory cell recruitment across the vasculature. This was enhanced by Trish's PhD studies in Professor Nash’s group where she investigated the contribution that platelets play in white blood cell adhesion and migration under physiological shear.

Professor Lalor was able to advance these studies in her postdoctoral projects to understand the unique phenotype of human hepatic sinusoidal endothelial cell and how these cells participate in the cellular regulation of human liver inflammation and fibrosis during liver disease. She now continues to work closely with clinical colleagues in the Centre for Liver and Gastroenterology Research to use the well validated cohorts of human samples available in our unit to develop human cell and tissue based models to understand the regulation of both acute and chronic liver injury.

Trish remains particularly interested in the contribution of sinusoidal endothelial cells and platelets to hepatic inflammation. Professor Lalor also has cross-disciplinary programmes of research that use novel biophysical and chemical tools to understand and potentially treat complex liver disease. She has a particular interest in metabolic liver disease and fibrosis.

Professor Lalor has funding from MRC and Wellcome schemes, BBSRC and The European Union to support her research and she also works with major pharmaceutical companies on collaborative projects. Her team is composed of both scientific and clinical researchers and she supervises PhD students funded on national and international schemes.

Teaching

Module co-ordinator for Liver Cell Biology in BMedSc year 3 with responsibility for delivering teaching and designing and marking assessments. Trish also teaches on the Stem cell module for year 2 and is a personal tutor on this course. Medical Science BMedSc
Clinical Science Bmedsci, supervisor for intercalating student projects and lecturing on the lier and GI module for this course Clinical Science BMedSc - Intercalated Degree
Supervisor for BMedSc3, research student projects and dissertation
Birmingham Foundation Academy, tutor for lectures and practical sessions for students enrolled on the Medical Sciences pathway Medical Sciences Pathway
Medicine and Surgery MBChB: student tutor, lecturer and mentor for SSA activities
PSIBS : lecturing and project supervision – Physical Sciences for Health

Postgraduate supervision

Professor Lalor has several current students on clinical, academic and industry funded programmes.

If you are interesting in studying any of these subject areas please contact Professor Patricia Lalor directly, or for any general doctoral research enquiries, please email mds-gradschool@contacts.bham.ac.uk.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.

Research

Research interests

Inflammation
Cell adhesion
Endothelial biology
Fibrogenesis
Liver metabolism
Alcohol-related liver injury
NAFLD
Toxic liver injury

Current projects

Marie Curie ITN – DeLiver
MRC CiC and WT ISSF – new therapeutic options in acute liver injury
BBSRC/ GSK Collaborative Training Partnership : human liver models to investigate hepatic clearance mechanisms
MRC Stratified Medicine Initiative – Minimising mortality in alcoholic hepatitis
Novo Nordisk: Research collaboration in NAFLD pathogenesis
Takeda : Collaborative research project in NASH

Other activities

Professor Lalor is a peer reviewer for major high impact, disciplinary journals including: Gastroenterology, PLosOne, Cell Transplantation, Gut, Hepatology, Journal of Leukocyte Biology, The American Journal of Transplantation, Inflammation Research, American Journal of Pathology, Liver International and Liver Transplantation.
NC3Rs Fellowship Grant committee member
Professor Lalor also also a peer reviews for funding applications (eg BHF Intermediate Fellowships, MRC Training Fellowships, MRC New Investigators Research Grants, Netherlands Organization for Scientific Research (NWO) grants, Austrian Science Fund (FWF) project grants, Agency for Science, Technology and Research (A*STAR) Singapore project grants)
Professor Lalor has run public engagement events for Think Tank, The Big Bang Fair and The QEHB showcase days

Publications

Recent publications

Article

Khan, R, Salman, S, Harford, L, Sheriff, L, Hazeldine, J, Rajoriya, N, Newsome, PN & Lalor, PF 2024, 'Circulating myeloid populations have prognostic utility in alcohol-related liver disease', Frontiers in immunology, vol. 15, 1330536. https://doi.org/10.3389/fimmu.2024.1330536

Horn, P, Norlin, J, Almholt, K, Viuff, BM, Galsgaard, ED, Hald, A, Zosel, F, Demuth, H, Poulsen, S, Norby, PL, Rasch, MG, Vyberg, M, Fleckner, J, Werge, MP, Gluud, LL, Rink, MR, Shepherd, E, Northall, E, Lalor, PF, Weston, CJ, Fog-Tonnesen, M & Newsome, PN 2024, 'Evaluation of Gremlin-1 as a therapeutic target in metabolic dysfunction-associated steatohepatitis', eLife, vol. 13, RP95185. https://doi.org/10.7554/elife.95185

Wilkinson, AL, Bannister, ME, O'Keeffe, A, Weston, CJ, Lalor, PF, Shetty, S & Patten, DA 2024, 'Protocol to study monocyte transmigration across primary human liver endothelial cells under physiological shear flow conditions in vitro', STAR Protocols, vol. 5, no. 4, 103431. https://doi.org/10.1016/j.xpro.2024.103431

Khan, S, Mahgoub, S, Fallatah, N, Lalor, PF & Newsome, PN 2023, 'Liver disease and cell therapy - advances made and remaining challenges', Stem Cells, vol. 41, no. 8. https://doi.org/10.1093/stmcls/sxad029

Podlogar, T, Shad, BJ, Seabright, AP, Odell, OJ, Lord, SO, Civil, R, Salgueiro, RB, Shepherd, EL, Lalor, PF, Elhassan, YS, Lai, Y-C, Rowlands, DS & Wallis, GA 2023, 'Postexercise muscle glycogen synthesis with glucose, galactose, and combined galactose-glucose ingestion', American Journal of Physiology - Endocrinology and Metabolism, vol. 325, no. 6, pp. E672-E681. https://doi.org/10.1152/ajpendo.00127.2022

Garg, A, Khan, S, Luu, N, Nicholas, DJ, Day, V, King, AL, Fear, J, Lalor, PF & Newsome, PN 2023, 'TGFβ₁ priming enhances CXCR3-mediated mesenchymal stromal cell engraftment to the liver and enhances anti-inflammatory efficacy', Journal of Cellular and Molecular Medicine, vol. 27, no. 6, pp. 864-878. https://doi.org/10.1111/jcmm.17698

Khan, RS, Lalor, PF, Thursz, M & Newsome, P 2023, 'The role of neutrophils in alcohol-related hepatitis', Journal of Hepatology, vol. 79, no. 4, pp. 1037-1048. https://doi.org/10.1016/j.jhep.2023.05.017

James, BH, Papakyriacou, P, Gardener, MJ, Gliddon, L, Weston, CJ & Lalor, PF 2022, 'The Contribution of Liver Sinusoidal Endothelial Cells to Clearance of Therapeutic Antibody', Frontiers in Physiology, vol. 12, 753833. https://doi.org/10.3389/fphys.2021.753833

Coltman, NJ, Coke, BA, Chatzi, K, Shepherd, EL, Lalor, PF, Schulz-Utermoehl, T & Hodges, NJ 2021, 'Application of HepG2/C3A liver spheroids as a model system for genotoxicity studies', Toxicology Letters, vol. 345, pp. 34-45. https://doi.org/10.1016/j.toxlet.2021.04.004

Sheriff, L & Lalor, P 2021, 'The impact of the NLRP3 pathway in the pathogenesis of non-alcoholic fatty liver disease and alcohol-related liver disease', Livers, vol. 1, no. 2, pp. 68-81. https://doi.org/10.3390/livers1020007

Sheriff, L, Khan, RS, Saborano, R, Wilkin, R, Luu, N, Gunther, UL, Hubscher, SG, Newsome, PN & Lalor, PF 2020, 'Alcoholic hepatitis and metabolic disturbance in female mice: a more tractable model than Nrf2-/- animals', Disease Models & Mechanisms, vol. 13, no. 12, dmm046383. https://doi.org/10.1242/dmm.046383

Shepherd, EL, Karim, S, Newsome, PN & Lalor, PF 2020, 'Inhibition of vascular adhesion protein-1 modifies hepatic steatosis in vitro and in vivo', World journal of hepatology, vol. 12, no. 11, pp. 931-948. https://doi.org/10.4254/wjh.v12.i11.931

Chapter

Shepherd, EL, Northall, E, Papakyriacou, P, Safranska, K, Sorensen, KK & Lalor, PF 2023, Decellularization of the Human Liver to Generate Native Extracellular Matrix for Use in Automated Functional Assays with Stellate Cells. in Hepatic Stellate Cells: Methods and Protocols. 1 edn, vol. 2669, Methods in molecular biology (Clifton, N.J.), pp. 233-244. https://doi.org/10.1007/978-1-0716-3207-9_14

Saborano, R, Shepherd, E, Günther, UL & Lalor, PF 2023, Tracer-Based Metabolic Analysis by NMR in Intact Perfused Human Liver Tissue. in Metabolic Reprogramming: Methods and Protocols. 1 edn, vol. 2675, Methods in molecular biology (Clifton, N.J.), Springer, pp. 167-180. https://doi.org/10.1007/978-1-0716-3247-5_13

Editorial

Lalor, PF, Huser, T & van Grunsven, LA 2022, 'Editorial: Roles of Liver Sinusoidal Endothelial Cells in Liver Homeostasis and Disease', Frontiers in Physiology, vol. 13, 869473. https://doi.org/10.3389/fphys.2022.869473

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