Professor Stefan Hübscher

Stefan Hübscher

Institute of Immunology and Immunotherapy
Leith Professor and Professor of Hepatic Pathology
Consultant Histopathologist

Contact details

Address
Department of Cellular Pathology
Queen Elizabeth Hospital
Birmingham
B15 2WB

Professor Stefan G Hübscher is Leith Professor and Professor of Hepatic Pathology, University of Birmingham and Consultant Histopathologist at University Hospitals Birmingham NHS Foundation Trust.

Research and clinical activities are mainly in the field of liver pathology, including the pathology of liver transplantation and hepatobiliary neoplasia.

Qualifications

  • Fellow of the Royal College of Pathologists (FRCPath), 1995
  • Member of the Royal College of Pathologists (MRCPath), 1985
  • MBChB, University of Birmingham, 1979

Publications

Recent publications

Article

LITMUS Investigators, Mózes, FE, Lee, J, Vali, Y, Alzoubi, O, Staufer, K, Trauner, M, Paternostro, R, Stauber, RE, Holleboom, AG, Van Dijk, A-M, Mak, AL, Boursier, J, De Saint Loup, M, Shima, T, Bugianesi, E, Gaia, S, Armandi, A, Shalimar, Lupșor-Platon, M, Wong, VW-S, Li, G, Wong, GL-H, Cobbold, J, Karlas, T, Wiegand, J, Sebastiani, G, Tsochatzis, E, Liguori, A, Yoneda, M, Nakajima, A, Hagström, H, Akbari, C, Hirooka, M, Chan, W-K, Mahadeva, S, Rajaram, R, Zheng, M-H, George, J, Eslam, M, Petta, S, Pennisi, G, Viganò, M, Ridolfo, S, Aithal, GP, Palaniyappan, N, Lee, DH, Ekstedt, M & Nasr, P 2023, 'Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis', The Lancet Gastroenterology & Hepatology, vol. 8, no. 8, pp. 704-713. https://doi.org/10.1016/S2468-1253(23)00141-3

Haller, W, Hodson, J, Brown, R, Lloyd, C, Hubscher, S, Mckiernan, P & Kelly, D 2023, 'The role of immunosuppression in long-term graft hepatitis and fibrosis after paediatric liver transplant comparison of two treatment protocols: comparison of two treatment protocols', Frontiers in Transplantation, vol. 1, 1042676. https://doi.org/10.3389/frtra.2022.1042676

Lohse, AW, Sebode, M, Bhathal, PS, Clouston, AD, Dienes, HP, Jain, D, Gouw, ASH, Guindi, M, Kakar, S, Kleiner, DE, Krech, T, Lackner, C, Longerich, T, Saxena, R, Terracciano, L, Washington, K, Weidemann, S, Hübscher, SG & Tiniakos, D 2022, 'Consensus recommendations for histological criteria of autoimmune hepatitis from the International AIH Pathology Group', Liver International, vol. 42, no. 5, pp. 1058-1069. https://doi.org/10.1111/liv.15217

Sheriff, L, Khan, RS, Saborano, R, Wilkin, R, Luu, N, Gunther, UL, Hubscher, SG, Newsome, PN & Lalor, PF 2020, 'Alcoholic hepatitis and metabolic disturbance in female mice: a more tractable model than Nrf2-/- animals', Disease Models & Mechanisms, vol. 13, no. 12, dmm046383. https://doi.org/10.1242/dmm.046383

Mergental, H, Laing, RW, Kirkham, AJ, Perera, MTPR, Boteon, YL, Attard, J, Barton, D, Curbishley, S, Wilkhu, M, Neil, DAH, Hübscher, SG, Muiesan, P, Isaac, JR, Roberts, KJ, Abradelo, M, Schlegel, A, Ferguson, J, Cilliers, H, Bion, J, Adams, DH, Morris, C, Friend, PJ, Yap, C, Afford, SC & Mirza, DF 2020, 'Transplantation of discarded livers following viability testing with normothermic machine perfusion', Nature Communications, vol. 11, no. 1, 2939. https://doi.org/10.1038/s41467-020-16251-3

Davies, SP, Reynolds, GM, Wilkinson, AL, Li, X, Rose, R, Leekha, M, Liu, YS, Gandhi, R, Buckroyd, E, Grove, J, Barnes, NM, May, RC, Hubscher, SG, Adams, DH, Huang, Y, Qureshi, O & Stamataki, Z 2019, 'Hepatocytes delete regulatory T cells by enclysis, a CD4+ T cell engulfment process', Cell Reports, vol. 29, no. 6, pp. 1610-1620.e4. https://doi.org/10.1016/j.celrep.2019.09.068

Jeffery, HC, Braitch, MK, Bagnall, C, Hodson, J, Jeffery, LE, Wawman, RE, Wong, LL, Birtwistle, J, Bartlett, H, Lohse, AW, Hirschfield, GM, Dyson, J, Jones, D, Hubscher, SG, Klenerman, P, Adams, DH & Oo, YH 2018, 'Changes in natural killer cells and exhausted memory regulatory T Cells with corticosteroid therapy in acute autoimmune hepatitis', Hepatology Communications, vol. 2, no. 4, pp. 421-436. https://doi.org/10.1002/hep4.1163

Mergental, H, Stephenson, BTF, Laing, RW, Kirkham, AJ, Neil, DAH, Wallace, LL, Boteon, YL, Widmer, J, Bhogal, RH, Perera, MTPR, Smith, A, Reynolds, GM, Yap, C, Hübscher, SG, Mirza, DF & Afford, SC 2018, 'Development of Clinical Criteria for Functional Assessment to Predict Primary Nonfunction of High-Risk Livers Using Normothermic Machine Perfusion', Liver Transplantation, vol. 24, no. 10, pp. 1453-1469. https://doi.org/10.1002/lt.25291

Trivedi, PJ, Hubscher, SG, Heneghan, M, Gleeson, D & Hirschfield, GM 2018, 'Grand round: autoimmune hepatitis', Journal of Hepatology. https://doi.org/10.1016/j.jhep.2018.11.006

Hirschfield, G, Dyson, JK, Alexander, GJ, Chapman, MH, Collier, J, Hubscher, S, Patanwala, I, Pereira, SP, Thain, C, Thorburn, D, Tiniakos, D, Walmsley, M, Webster, G & Jones, DE 2018, 'The British Society of Gastroenterology/UK-PBC Primary Biliary Cholangitis Treatment and Management Guidelines', Gut. https://doi.org/10.1136/gutjnl-2017-315259

Eddowes, PJ, McDonald, N, Davies, N, Semple, SIK, Kendall, TJ, Hodson, J, Newsome, PN, Flintham, RB, Wesolowski, R, Blake, L, Duarte, RV, Kelly, CJ, Herlihy, AH, Kelly, MD, Olliff, SP, Hubscher, SG, Fallowfield, JA & Hirschfield, GM 2018, 'Utility and cost evaluation of multiparametric magnetic resonance imaging for the assessment of non-alcoholic fatty liver disease', Alimentary Pharmacology & Therapeutics, vol. 47, no. 5, pp. 631-644. https://doi.org/10.1111/apt.14469

Dah, N, Co, B, Smith, M, Haga, H, Zen, Y, Sebagh, M, Ruppert, K, Lunz, J, Hübscher, SG & Demetris, AJ 2017, 'Global quality assessment of liver allograft C4d staining during acute antibody mediated rejection in formalin-fixed paraffin-embedded tissue', Human Pathology. https://doi.org/10.1016/j.humpath.2017.12.007

Laing, RW, Bhogal, RH, Wallace, L, Boteon, Y, Neil, DAH, Smith, A, Stephenson, BTF, Schlegel, A, Hübscher, SG, Mirza, DF, Afford, SC, Mergental, H & Hubscher, S 2017, 'The Use of an Acellular Oxygen Carrier in a Human Liver Model of Normothermic Machine Perfusion', Transplantation, vol. 101, no. 11, pp. 2746-2756. https://doi.org/10.1097/TP.0000000000001821

de Vries, EMG, de Krijger, M, Färkkilä, M, Arola, J, Schirmacher, P, Gotthardt, D, Goeppert, B, Trivedi, PJ, Hirschfield, GM, Ytting, H, Vainer, B, Buuren, HRV, Biermann, K, Harms, MH, Chazouilleres, O, Wendum, D, Kemgang, AD, Chapman, RW, Wang, LM, Williamson, KD, Gouw, ASH, Paradis, V, Sempoux, C, Beuers, U, Hübscher, SG, Verheij, J & Ponsioen, CY 2017, 'Validation of the prognostic value of histologic scoring systems in primary sclerosing cholangitis: An international cohort study', Hepatology, vol. 65, no. 3, pp. 907-919. https://doi.org/10.1002/hep.28963

Review article

Clouston, AD, Gouw, ASH, Tiniakos, D, Bedossa, P, Brunt, EM, Callea, F, Dienes, HP, Goodman, ZD, Hubscher, SG, Kakar, S, Kleiner, DE, Lackner, C, Park, YN, Roberts, EA, Schirmacher, P, Terracciano, L, Torbenson, M, Wanless, IR, Zen, Y & Burt, AD 2024, 'Severe acute liver disease in adults: Contemporary role of histopathology', Histopathology. https://doi.org/10.1111/his.15212

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