Recent publications
Article
Mahida, RY, Yuan, Z, Kolluri, KK, Scott, A, Parekh, D, Hardy, RS, Matthay, MA, Perkins, GD, Janes, SM & Thickett, DR 2024, '11β hydroxysteroid dehydrogenase type 1 transgenic mesenchymal stem cells attenuate inflammation in models of sepsis', Frontiers in Bioengineering and Biotechnology, vol. 12, 1422761. https://doi.org/10.3389/fbioe.2024.1422761
Heaselgrave, S, Henkele, S, Morgan, S, Cartwright, D, Sagmeister, M, Hardy, R, Doig, C, Morton, N, Tsintzas, K & Lavery, GG 2024, 'Glucocorticoid excess alters metabolic rate and substrate utilisation via 11β-HSD1', Journal of Endocrinology. https://doi.org/10.1530/JOE-24-0205
Tomkins, M, McDonnell, T, Cussen, L, Sagmeister, M, Oestlund , I, Shaheen, F, Harper, L, Hardy, R, Taylor, A, Gilligan, L, Arlt, W, McIlroy , M, de Freitas , D, Conlon , P, Magee, C, Denton, M, O'Seaghdha, CM, Snoep, JL, Storbeck, K-H, Sherlock, M & O'Reilly, MW 2024, 'Impaired 11β-hydroxysteroid dehydrogenase type 2 activity in chronic kidney disease disrupts 11-oxygenated androgen biosynthesis', Journal of Clinical Endocrinology and Metabolism. https://doi.org/10.1210/clinem/dgae714
Mangone, A, Favero, V, Prete, A, Elhassan, Y, Asia, M, Hardy, R, Mantovani, G, Chiodini, I & Ronchi, C 2024, 'Inflammation-based scores in a large cohort of adrenocortical carcinoma and adrenocortical adenoma: role of the hormonal secretion pattern', Journal of endocrinological investigation. https://doi.org/10.1007/s40618-024-02426-y
Martin, CS, Crastin, A, Sagmeister, MS, Kalirai, MS, Turner, JD, MacDonald, L, Kurowska-Stolarska, M, Scheel-Toellner, D, Taylor, AE, Gilligan, LC, Storbeck, K, Price, M, Gorvin, CM, Filer, A, Mahida, R, Clark, AR, Jones, SW, Raza, K, Hewison, M & Hardy, RS 2024, 'Inflammation Dynamically Regulates Steroid Hormone Metabolism and Action within Macrophages in Rheumatoid Arthritis ', Journal of Autoimmunity, vol. 147, 103263. https://doi.org/10.1016/j.jaut.2024.103263
Webster, JM, Waaijenberg, K, van de Worp, WRPH, Kelders, MCJM, Lambrichts, S, Martin, C, Verhaegen, F, Van der Heyden, B, Smith, C, Lavery, GG, Schols, AMWJ, Hardy, RS & Langen, RCJ 2023, '11β-HSD1 determines the extent of muscle atrophy in a model of acute exacerbation of COPD', American journal of physiology. Lung cellular and molecular physiology, vol. 324, no. 4, pp. L400-L412. https://doi.org/10.1152/ajplung.00009.2022
O’Neil, JD, Bolimowska, OO, Clayton, SA, Tang, T, Daley, KK, Lara-Reyna, S, Warner, J, Martin, CS, Mahida, RY, Hardy, RS, Arthur, JSC & Clark, AR 2023, 'Dexamethasone impairs the expression of antimicrobial mediators in lipopolysaccharide-activated primary macrophages by inhibiting both expression and function of interferon β', Frontiers in immunology, vol. 14, 1190261. https://doi.org/10.3389/fimmu.2023.1190261
Hansen, MS, Søe, K, Christensen, LL, Fernandez-Guerra, P, Hansen, NW, Wyatt, RA, Martin, C, Hardy, RS, Andersen, TL, Olesen, JB, Hartmann, B, Rosenkilde, MM, Kassem, M, Rauch, A, Gorvin, C & Frost, M 2023, 'GIP reduces osteoclast activity and improves osteoblast survival in primary human bone cells', European Journal of Endocrinology , vol. 188, no. 1, lvac004. https://doi.org/10.1093/ejendo/lvac004
Mahida, RY, Lax, S, Bassford, CR, Scott, A, Parekh, D, Hardy, RS, Naidu, B, Matthay, MA, Stewart, PM, Cooper, MC, Perkins, GD & Thickett, DR 2023, 'Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS', Frontiers in immunology, vol. 14, 1159831. https://doi.org/10.3389/fimmu.2023.1159831
Favero, V, Prete, A, Mangone, A, Elhassan, Y, Pucino, V, Asia, M, Hardy, R, Chiodini, I & Ronchi, C 2023, 'Inflammation-based Scores In Benign Adrenocortical Tumours Are Linked To The Degree Of Cortisol Excess: a retrospective single centre study', European Journal of Endocrinology, vol. 183, lvad151, pp. 517-526. https://doi.org/10.1093/ejendo/lvad151
Merk, VM, Phan, TS, Wiedmann, A, Hardy, RS, Lavery, GG & Brunner, T 2023, 'Local glucocorticoid synthesis regulates house dust mite-induced airway hypersensitivity in mice', Frontiers in immunology, vol. 14, 1252874. https://doi.org/10.3389/fimmu.2023.1252874
Fenton, CG, Crastin, A, Martin, CS, Suresh, S, Montagna, I, Hussain, B, Naylor, AJ, Jones, SW, Hansen, MS, Gorvin, CM, Price, M, Filer, A, Cooper, MS, Lavery, GG, Raza, K & Hardy, RS 2022, '11β-hydroxysteroid dehydrogenase type 1 within osteoclasts mediates the bone protective properties of therapeutic corticosteroids in chronic inflammation', International Journal of Molecular Sciences, vol. 23, no. 13, 7334, pp. 7334. https://doi.org/10.3390/ijms23137334
Review article
Chidomere, CI, Wahid, M, Kemble, S, Chadwick, C, Thomas, R, Hardy, RS, Mcgettrick, HM & Naylor, AJ 2023, 'Bench to Bedside: Modelling Inflammatory Arthritis', Discovery Immunology, vol. 2, no. 1, kyac010. https://doi.org/10.1093/discim/kyac010
Sagmeister, M, Harper, L & Hardy, R 2023, 'Cortisol excess in chronic kidney disease: – a review of changes and impact on mortality', Frontiers in Endocrinology, vol. 13, 1075809. https://doi.org/10.3389/fendo.2022.1075809
Nicholson, TA, Sagmeister, M, Wijesinghe, SN, Farah, H, Hardy, RS & Jones, SW 2023, 'Oligonucleotide Therapeutics for Age-Related Musculoskeletal Disorders: Successes and Challenges', Pharmaceutics, vol. 15, no. 1, 237. https://doi.org/10.3390/pharmaceutics15010237
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