Professor Andy Wilson FRSC, FHEA

School of Chemistry
Professor of Chemical Biology

Contact details

Email: a.j.wilson.1@bham.ac.uk
Twitter: @ajwilsongroup

Address: School of Chemistry
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Andy Wilson is a Professor in the School of Chemistry

The Wilson group are interested in the application of synthetic molecules to problems in Chemical Biology and Materials Science. We pursue both curiosity driven fundamental research and mission inspired research addressing societal challenges.

The group is currently supported by The University of Birmingham, EPSRC and BBSRC.

Our group is participating in several large-scale, multi-investigator programmes including SPIDR, a major BBSRC investment, and led on the EPSRC PoPPI Programme.

Qualifications

PhD in Synthetic Chemistry with Professor David A. Leigh FRS, “The Controlled Assembly of Interlocked Architectures”. University of Warwick 1998-2000, The University of Manchester Institute of Science and Technology (UMIST) 1997-1998. 2000

BSc (Hons) Chemistry 1st Class at UMIST 1997

Publications

M. A. Jinks, M. Howard, F. Rizzi, S. M. Goldup, A. D. Burnett, A. J. Wilson*: Direct Detection of Hydrogen Bonds in Supramolecular Systems Using ¹H-¹⁵N Heteronuclear Multiple Quantum Coherence Spectroscopy, J. Am. Chem. Soc., 2022, 50, 23127-23133. View Paper.

T. Ueda, T. Tamura, M. Kawano, K. Shiono, F. Hobor, A. J. Wilson, I. Hamachi*: Enhanced suppression of a protein-protein interaction in cells using small-molecule covalent inhibitors based on N-acyl-N-alkyl sulfonamide warhead, J. Am. Chem. Soc. , 2021, 143, 4766-4774. View Paper.

S. Celis, F. Hobor, T. James, G. J. Bartlett, A. A. Ibarra, D. K. Shoemark, Z. Hegedus, K. Hetherington, D. N. Woolfson, R. B. Sessions, T. A. Edwards, D. M. Andrews,* A. Nelson,* A. J. Wilson*: Query-Guided Protein-Protein Interaction Inhibitor Discovery, Chem. Sci., 2021, 12, 4753-4762. View Paper.

Z. Hegedüs, F. Hobor, D. K Shoemark, L.-Y. Lian, C. Trinh, R. B. Sessions, T. A. Edwards, A. J. Wilson*: Identification of β-Strand Mediated Protein-Protein Interaction Inhibitors Using Ligand-Directed Fragment Ligation, Chem. Sci., 2021, 12, 2286-2293. View Paper.

E. E. Cawood, N. Guthertz, J. Ebo, T. K. Karamanos, S. E. Radford,* A. J. Wilson*: Modulation of amyloidogenic protein self-assembly using tethered small molecules, J. Am. Chem. Soc., 2020, 142, 20845-20854. View Paper.

S. J. Bunce, Y. Wang, K. L. Stewart, A. E. Ashcroft, S. E. Radford,* C. K. Hall,* A. J. Wilson*: Molecular Insights into the surface catalyzed secondary nucleation of Amyloid-β40 (Aβ40) by the peptide fragment Aβ16-22, Sci. Adv., 2019, 5, eaav8216. View Paper.

J. E. Horne, M. Walko, A. N. Calabrese, M. A. Levenstein, D. J. Brockwell, N. Kapur, A. J. Wilson*, S. E. Radford*: Rapid Mapping of Protein Interactions Using Tag-Transfer Photocrosslinkers, Angew. Chemie. Int. Ed., 2018, 57, 16688–16692. View Paper.

J. M. Fletcher, K. A. Horner, G. J Bartlett, G. R. Rhys, A. J. Wilson,* D. N. Woolfson*: De novo coiled-coil peptides as scaffolds for disrupting protein-protein interactions, Chem. Sci., 2018, 9, 7656-7665. View Paper.

J. A. Miles, D. J. Yeo, Philip Rowell, S. Rodriguez-Marin, C. M. Pask, S. L. Warriner, T. A. Edwards*, A. J. Wilson*: Hydrocarbon Constrained Peptides – Understanding Preorganization and Binding Affinity, Chem. Sci., 2016, 7, 3694-3702. View Paper.

A. Barnard, K. Long, H. L. Martin, J. A. Miles, T. A. Edwards, D. C. Tomlinson, A. Macdonald,* A. J. Wilson*: Selective and Potent Proteomimetic Inhibitors of Intracellular Protein-Protein Interactions, Angew. Chem. Int. Ed. , 2015, 54, 2960-2965. View Paper.

View all publications in research portal