Professor Katja Gehmlich

Katja Gehmlich

Institute of Cardiovascular Sciences
Professor of Molecular Cardiology

Contact details

Telephone
+44 (0) 121 414 8529
Email
k.gehmlich@bham.ac.uk
View my research portal
Address
Institute of Cardiovascular Sciences
College of Medical and Dental Sciences
Univeristy of Birmingham
Edgbaston
Birmingham
B15 2TT

Professor Katja Gehmlich is interested in how genetic variants in genes coding for proteins involved in biomechanical stress signalling cause inherited cardiac conditions (cardiomyopathies). She employs molecular, biophysical, cellular and in vivo models in her research. In particular she is interested in using induced pluripotent stem cell derived cardiomyocytes in her research.

Qualifications

  • PhD (Dr. rer. nat.) in Cell Biology 2005
  • Diploma (MSc equivalent) in Chemistry 2001

Biography

Professor Katja Gehmlich graduated with a Diploma in Chemistry (with Molecular and Cellular Biology) from the University of Potsdam, Germany in 2001. She received a PhD in Cell Biology from the same university in 2005.

Professor Gehmlich came to the UK for her postdoctoral training and work at the University of Manchester (2005-2007), University College London (2007 – 2010) and University of Oxford (2010 – 2013).

She was awarded a British Heart Foundation Intermediate Basic Science Research Fellowship (2013 – 2020). She received the title University Research Lecturer from the University of Oxford in 2016 and became Associate Professor in 2018. She has an active secondary affiliation with Cardiovascular Medicine in the Radcliffe Department of Medicine at the University of Oxford.

In 2019, she became Associate Professor in Cardiovascular Science at the Institute of Cardiovascular Sciences, University of Birmingham, also Visiting Associate Professor at the University of Oxford. In 2024, she was promoted to Professor of Molecular Cardiology.

She has a long standing interest in the cardiac system with focus on inherited cardiac conditions (cardiomyopathies) and bio-mechanical stress signalling.

Teaching

Professor Katja Gehmlich has extensive experience in supervision of undergraduate research students.

Postgraduate supervision

Professor Katja Gehmlich has supervised numerous postgraduate students (2 completed, one active).

She accepts PhD students in her group, e.g. with interest in projects using induced pluripotent stem cell derived cardiomyocytes to understand biomechanical stress signalling in the heart.

Research

Professor Katja Gehmlich has a long standing interest into striated muscle systems.

Her research pursues the following questions:

  • What is the role of certain signalling proteins in the heart?
  • What are the consequences of genetic variants in these proteins? How do they cause inherited cardiac conditions (called cardiomyopathies)?
  • Can these diseases be modelled with the help of in vivo models and/or induced pluripotent stem cell derived cardiomyocytes?


Professor Gehmlich collaborates with other research groups such as:

Other activities

Professor Katja Gehmlich is peer reviewer for various International journals and funding agencies. She is member of the editorial board of Biophysical Reviews.

Publications

Recent publications

Article

Roy, A, Cumberland, M, O'Shea, C, Holmes, A, Kalla, M, Gehmlich, K, Geberhiwot, T & Steeds, R 2024, 'Arrhythmogenesis in Fabry Disease', Current cardiology reports. https://doi.org/10.1007/s11886-024-02053-2

Patel, L, Roy, A, Barlow, J, O'Shea, C, Nieves, D, Azad, A, Hall, C, Davies, B, Rath, P, Pavlovic, D, Chikermane, A, Geberhiwot, T, Steeds, R & Gehmlich, K 2024, 'Characterisation of infantile cardiomyopathy in Alström Syndrome using ALMS1 Knockout induced pluripotent stem cell derived cardiomyocyte model', Molecular Genetics and Metabolism, vol. 143, no. 1-2, 108575. https://doi.org/10.1016/j.ymgme.2024.108575

Roy, A, Patel, L, Yuan, M, O'Shea, C, Alvior, AMB, Charalambides, M, Moxon, D, Baig, S, Bunting, KV, Gehmlich, K, Geberhiwot, T & Steeds, R 2024, 'Defining the cardiovascular phenotype of adults with Alström syndrome', International Journal of Cardiology, vol. 409, 132212. https://doi.org/10.1016/j.ijcard.2024.132212

Fabritz, L, Fortmueller, L, Gehmlich, K, Kant, S, Kemper, M, Kucerova, D, Syeda, F, Faber, C, Leube, R, Kirchhof, P & Krusche, CA 2024, 'Endurance training provokes Arrhythmogenic Right Ventricular Cardiomyopathy phenotype in heterozygous Desmoglein 2 mutants: Alleviation by preload reduction', Biomedicines, vol. 12, no. 5, 985. https://doi.org/10.3390/biomedicines12050985

Støle, TP, Lunde, M, Gehmlich, K, Christensen, G, Louch, WE & Carlson, CR 2024, 'Exploring Syndecan-4 and MLP, and Their Interaction, in Primary Cardiomyocytes and H9c2 Cells', Cells, vol. 13, no. 11, 947. https://doi.org/10.3390/cells13110947

McKay, EJ, Luijten, I, Broadway-Stringer, S, Thomson, A, Weng, X, Gehmlich, K, Gray, GA & Semple, RK 2024, 'Female Alms1-deficient mice develop echocardiographic features of adult but not infantile Alström Syndrome cardiomyopathy', Disease Models & Mechanisms. https://doi.org/10.1242/dmm.050561

Gehmlich, K & Krause, S 2024, 'Gender distribution of scientific prizes is associated with naming of awards after men, women or neutral', Data, vol. 9, no. 7, 84. https://doi.org/10.3390/data9070084

Cumberland, M, Euchner, J, Azad, A, Vo, NTN, Kirchhof, P, Holmes, A, Denning, C & Gehmlich, K 2024, 'Generation of a human iPSC-derived cardiomyocyte/fibroblast engineered heart tissue model [version 1; peer review: 1 approved, 2 approved with reservations]', F1000Research, vol. 12, 1224. https://doi.org/10.12688/f1000research.139482.1

Reyat, J, Sommerfeld, L, O'Reilly, M, Roth Cardoso, V, Thiemann, E, Khan, A, O'Shea, C, Harder, S, Müller, C, Barlow, J, Stapley, R, Chua, WWL, Kabir, N, Grech, O, Hummel, O, Hübner, N, Kaab, S, Mont, L, Hatem, SN, Winters, J, Zeemering, S, Morgan, N, Rayes, J, Gehmlich, K, Stoll, M, Brand, T, Schweizer , M, Piasecki, A, Schotten, U, Gkoutos, G, Lorenz, K, Cuello, F, Kirchhof, P & Fabritz, L 2024, 'PITX2 deficiency leads to atrial mitochondrial dysfunction', Cardiovascular Research. https://doi.org/10.1093/cvr/cvae169

Sommerfeld, LC, Holmes, AP, Yu, TY, O'Shea, C, Kavanagh, DM, Pike, JM, Wright, T, Syeda, F, Aljehani, A, Kew, T, Cardoso, VR, Kabir, SN, Hepburn, C, Menon, PR, Broadway‐Stringer, S, O'Reilly, M, Witten, A, Fortmueller, L, Lutz, S, Kulle, A, Gkoutos, GV, Pavlovic, D, Arlt, W, Lavery, GG, Steeds, R, Gehmlich, K, Stoll, M, Kirchhof, P & Fabritz, L 2024, 'Reduced plakoglobin increases the risk of sodium current defects and atrial conduction abnormalities in response to androgenic anabolic steroid abuse', The Journal of Physiology. https://doi.org/10.1113/jp284597

Hall, C, Law, JP, Reyat, JS, Cumberland, MJ, Hang, S, Vo, NTN, Raniga, K, Weston, CJ, O’Shea, C, Townend, JN, Gehmlich, K, Ferro, CJ, Denning, C & Pavlovic, D 2023, 'Chronic activation of human cardiac fibroblasts in vitro attenuates the reversibility of the myofibroblast phenotype', Scientific Reports, vol. 13, no. 1, 12137. https://doi.org/10.1038/s41598-023-39369-y

Gehmlich, K & Krause, S 2023, 'How we name academic prizes matters', Nature Human Behaviour. https://doi.org/10.1038/s41562-023-01773-9

Broadway-Stringer, S, Jiang, H, Wadmore, K, Hooper, C, Douglas, G, Steeples, V, Azad, AJ, Singer, E, Reyat, JS, Galatik, F, Ehler, E, Bennett, P, Kalisch-Smith, JI, Sparrow, DB, Davies, B, Djinovic-Carugo, K, Gautel, M, Watkins, H & Gehmlich, K 2023, 'Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2', Cells, vol. 12, no. 5, 721. https://doi.org/10.3390/cells12050721

Patel, L, Roy, A, Mia B Alvor, A, Yuan, M, Baig, S, V Bunting, K, Hodson, J, Gehmlich, K, M Lord, J, Geberhiwot, T & Paul Steeds, R 2023, 'Phenoage and longitudinal changes on transthoracic echocardiography in Alström Syndrome: A disease of accelerated ageing?', GeroScience. https://doi.org/10.1007/s11357-023-00959-3

McColgan, G, Villarroel, M & Gehmlich, K 2023, 'Should young athletes be screened for cardiomyopathies to reduce the burden of sudden cardiac death in athletes?', Biophysical Reviews, vol. 15, no. 3, pp. 321-327. https://doi.org/10.1007/s12551-023-01085-2

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