Recent publications
Article
Bilateral Remote Ischemic Conditioning in Children Trial Investigators, Drury, NE, Doorn, CV, Woolley, RL, Amos-Hirst, RJ, Bi, R, Spencer, CM, Morris, KP, Montgomerie, J, Stickley, J, Crucean, A, Gill, A, Hill, M, Weber, RJM, Najdekr, L, Jankevics, A, Southam, AD, Lloyd, GR, Jaber, O, Kassai, I, Pelella, G, Khan, NE, Botha, P, Barron, DJ, Madhani, M, Dunn, WB, Ives, NJ, Kirchhof, P & Jones, TJ 2024, 'Bilateral Remote Ischemic Conditioning in Children: a two-center, double-blind, randomized controlled trial in young children undergoing cardiac surgery', The Journal of Thoracic and Cardiovascular Surgery, vol. 18, pp. 193-208. https://doi.org/10.1016/j.xjon.2024.02.018
Griffiths, K, Grand, RJ, Horan, I, Certo, M, Keeler, RC, Mauro, C, Tseng, C-C, Greig, I, Morrell, NW, Zanda, M, Frenneaux, MP & Madhani, M 2024, 'Fluorinated perhexiline derivative attenuates vascular proliferation in pulmonary arterial hypertension smooth muscle cells', Vascular Pharmacology, vol. 156, 107399. https://doi.org/10.1016/j.vph.2024.107399
Griffiths, K, Ida, T, Morita, M, Lamb, RJ, Lee, JJ, Frenneaux, MP, Fukuto, JM, Akaike, T, Feelisch, M & Madhani, M 2023, 'Cysteine hydropersulfide reduces lipid peroxidation and protects against myocardial ischaemia-reperfusion injury: - Are endogenous persulfides mediators of ischaemic preconditioning?', Redox Biology, vol. 60, 102605. https://doi.org/10.1016/j.redox.2023.102605
Griffiths, K, Lee, J, Frenneaux, M, Feelisch, M & Madhani, M 2021, 'Nitrite and myocardial ischaemia reperfusion injury. Where are we now?', Pharmacology & Therapeutics, vol. 223, 107819. https://doi.org/10.1016/j.pharmthera.2021.107819
Drury, N, Bi, R, Woolley, R, Stickley, J, Morris, KP, Montgomerie, J, Doorn, CV, Dunn, W, Madhani, M, Ives, N, Kirchhof, P & Jones, T 2020, 'Bilateral Remote Ischaemic Conditioning in Children (BRICC) trial: protocol for a two-centre, double-blind, randomised controlled trial in young children undergoing cardiac surgery', BMJ open, vol. 10, no. 10, e042176. https://doi.org/10.1136/bmjopen-2020-042176
Feelisch, M, Akaike, T, Griffiths, K, Ida, T, Prysyahna, O, Goodwin, JJ, Gollop, ND, Fernandez, BO, Minnion, M, Cortese-Krott, MM, Borgognone, A, Hayes, RM, Eaton, P, Frenneaux, MP & Madhani, M 2020, 'Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides, and oxidation of protein kinase G1α redox signalling', Cardiovascular Research, vol. 116, no. 1, pp. 51-62. https://doi.org/10.1093/cvr/cvz202
Sutton, TR, Minnion, M, Barbarino, F, Koster, G, fernandez, BO, Cumpstey, AF, Wischmann, P, Madhani, M, Frenneaux, MP, Postle, AD, Cortese-Krott, MM & Feelisch, M 2018, 'A robust and versatile mass spectrometry platform for comprehensive assessment of the thiol redox metabolome', Redox Biology, vol. 16, pp. 359-380. https://doi.org/10.1016/j.redox.2018.02.012
Borgognone, A, Shantsila, E, Worrall, S, Prompunt, E, Loka, T, Loudon, BL, Chimen, M, Rainger, E, Lord, JM, Turner, A, Nightingale, P, Feelisch, M, Kirchhof, P, Lip, G, Watson, SP, Frenneaux, MP & Madhani, M 2018, 'Nitrite circumvents platelet resistance to nitric oxide in patients with heart failure preserved ejection fraction and chronic atrial fibrillation', Cardiovascular Research, vol. 114, pp. 1313–1323. https://doi.org/10.1093/cvr/cvy087
Noordali, H, Loudon, B, Frenneaux, M & Madhani, M 2017, 'Cardiac metabolism - a promising therapeutic target for heart failure', Pharmacology & Therapeutics. https://doi.org/10.1016/j.pharmthera.2017.08.001
Madhani, M 2017, 'Development of Fluorinated Analogues of Perhexiline with Improved Pharmacokinetic Properties and Retained Efficacy', Journal of Medicinal Chemistry, vol. 60, no. 7, pp. 2780-2789. https://doi.org/10.1021/acs.jmedchem.6b01592
Madhani, M 2017, 'Inorganic Nitrate in Angina Study: A Randomized Double-Blind Placebo-Controlled Trial', Journal of the American Heart Association, vol. 6, no. 9, e006478. https://doi.org/10.1161/JAHA.117.006478
Madhani, M, Noordali, H, Frenneaux, M, Loudon, B & Gollop, ND 2016, 'Present and future pharmacotherapeutic agents in heart failure: An evolving paradigm', British Journal of Pharmacology, vol. 173 , no. 12, pp. 1911-1924. https://doi.org/10.1111/bph.13480
Arif, S, Borgognone, A, Lin, EL, O'sullivan, AG, Sharma, V, Drury, NE, Menon, A, Nightingale, P, Mascaro, J, Bonser, RS, Horowitz, JD, Feelisch, M, Frenneaux, MP & Madhani, M 2015, 'Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans', British Journal of Pharmacology, vol. 172, no. 13, pp. 3341-3352. https://doi.org/10.1111/bph.13122
Ormerod, JOM, Arif, S, Mukadam, M, Evans, JDW, Beadle, R, Fernandez, BO, Bonser, RS, Feelisch, M, Madhani, M & Frenneaux, MP 2015, 'Short-term intravenous sodium nitrite infusion improves cardiac and pulmonary hemodynamics in heart failure patients', Circulation. Heart failure, vol. 8, no. 3, pp. 565-571. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001716
Review article
Lamb, RJ, Griffiths, K, Lip, GYH, Sorokin, V, Frenneaux, MP, Feelisch, M & Madhani, M 2024, 'ALDH2 polymorphism and myocardial infarction: From alcohol metabolism to redox regulation', Pharmacology & Therapeutics, vol. 259, 108666. https://doi.org/10.1016/j.pharmthera.2024.108666
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