Blakemore, D., Vilaplana-Lopera, N., Almaghrabi, R.,…. and García, P*. (2021) MYBL2 and ATM suppress replication stress in pluripotent stem cells. EMBO Reports. DOI: 10.15252/embr.202051120
Jianming Wang, Patricia Rojas, Jingwen Mao, Ho Leung, Martin Higgs, Paloma Garcia, Marco Saponaro. (2021). Persistence of RNA transcription at transcription start sites during DNA replication induces G2/M DNA synthesis Cell Reports.https://doi.org/10.1016/j.celrep.2021.108759
Gleneadie HJ, Baker A, Batis N, Bryant J, Jiang Y, Clokie SJH, Mehanna H, Garcia P, Gendoo DMA, Roberts S, Molinolo AA, Gutkind JS, Scheven BA, Cooper PR, Khanim FL, Wiench M. (2021) A common analgesic enhances the anti-tumour activity of 5-aza-2’-deoxycytidine through induction of oxidative stress Cancer Letters. doi: 10.1016/j.canlet.2020.12.029.
Bayley,R., Ward, C., and García, P*. (2020) MYBL2 Amplification in Breast Cancer: Molecular Mechanisms and Therapeutic Potential. BBA:Reviews on Cancer. DOI: 10.1016/j.bbcan.2020.188407
Muñoa‑Hoyos, I., Halsall, J.A., Araolaza, M., Ward, C., Garcia, I., Urizar‑Arenaza, I., Gianzo, M., García, P., Turner, ., and Subirán, N. (2020) Morphine leads to global genome changes in H3K27me3 levels via a Polycomb Repressive Complex 2 (PRC2) self‑regulatory mechanism in mESCs. Clin Epigenet 12:170. https://doi.org/10.1186/s13148-020-00955-w
Ward, C., Volpe, G., Ptasinska, A., Nafria Fedi, Cauchy, P., M., Frampton, K., Murphy, G., Buganim, Y., Kaji, K., and García, P*. (2018) Fine-tuning Mybl2 is required for proper mesenchymal-to-epithelial transition during somatic reprogramming. Cell Reports 24 (6): 1496-1511. DOI:10.1016/j.celrep.2018.07.026.
Bayley, R., Blakemore, D., Cancian, L., Dumon, S., Volpe, G., Ward, C., AlMaghrabi, R., Gujar, J., Reeve, N., Raghavan, M., Stewart, G., Higgs, M., Petermann, E., and García, P*. (2018) MYBL2 supports DNA double strand break repair in Haematopoietic Stem Cells. Cancer Research DOI: 10.1158/0008-5472.CAN-18-0273.
Volpe, G., Walton, D. S., Grainger, D.E., Ward, C., Cauchy, P., Blakemore, D., Coleman, D.J.L., Cockerill, P.N., García, P*., Frampton, J*. (2017) Prognostic significance of high GFI1expressionin AML of normal karyotype and its association with a FLT3-ITD signature. Scientific Reports, 7. DOI:10.1038/s41598-017-11718-8.
Clarke, M. L., Volpe, G., Sheriff, L., Walton, D., Ward, C., Wei, W., Dumon, S., García, P* and Frampton, J*. (2017) Transcriptional regulation of SPROUTY 2 and DUSP6 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3. Leukaemia Apr; 31(4): 957–966. DOI: 10.1038/leu.2016.289
Iltzsche, F., Simon, K., Stopp, S., Pattschull, G., Francke, S., Wolter, P., Hauser, S., Murphy, D., García, P, Rosenwald, A., and Gaubatz, S. (2017) An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma. Oncogene 36:110-121 DOI:10.1038/onc.2016.181
Volpe, G., Clarke,M.L., García, P., Walton, D. S.,et al. (2015) Regulation of the Flt3 Gene in Haematopoietic Stem and Early Progenitor Cells. PLOS One. DOI: 10.1371/journal.pone.0138257
Dolz, S., García, P., Llop, M., Fuster, O.,et al. (2015) Study of the S427G polymorphism and of MYBL2variants in patients with acute myeloid leukemia. Leukaemia & Lymphoma. DOI:10.3109/10428194.2015.1049167
Sakamoto, H., Takeda, N., Arai, F., Hosokawa, K., García, P., Suda, T., Frampton, J., and Ogawa, M. (2015). Determining c-Myb Protein Levels Can Isolate Functional Hematopoietic Stem Cell Subtypes Stem Cells, 33 (2): 479-490.
Fuster, O., Llop, M., Dolz, S., García, P., Such, E.,et al. (2013) Adverse prognostic value of MYBL2 overexpression and association with microRNA-30 family in acute myeloid leukemia patients. Leukaemia Research, 37 (12): 1690-6.
Volpe, G., Walton, D. S., Del Pozzo, W., García, P., Dasse, E., O'Neill, L., Griffiths, M., Frampton, J., and Dumon, S. (2013) C/EBPa and MYB regulate FLT3 expression in AML. Leukaemia, 27:1487-96.
Clarke, M.L., Dumon, S., Ward, C., Jager, R., Freeman, S., Dawood, B., Sheriff, L., Lorvellec, M., Kralovics, R., Frampton, J and García, P*. (2013) MybL2 haploinsufficiency increases susceptibility to age-related haemopoietic neoplasia. Leukaemia, 27: 661–670.
Jones, R.M., Mortusewicz,O., Afzal, I., Lorvellec, M., García, P., Helleday, T and Petermann, E.(2013) Oncogene-induced replication stress by increased replication initiation resulting in conflicts with transcription. Oncogene, 32: 3744-53.
Haining, E.J., Yang, J., Bailey,R. L., Khan, K., Collier, R., Tsai, S., Watson,S.P., Frampton, J., García, P., Tomlinson M. (2012) The TspanC8 Subgroup of Tetraspanins Interacts with A Disintegrin and Metalloprotease 10 (ADAM10) and Regulates Its Maturation and Cell Surface Expression. J Biol Chem, 287(47): 39753-65.
García, P*., Berlanga, O., Vegiopoulos, A., Vyas, P and Frampton, J. (2011). c-Myb and GATA-1 alternate dominant roles during megakaryocyte differentiation. J Thromb Haemost, 9(8):1572-1581.
Lorvellec, M., Dumon, S., Maya-Mendoza, A., Jackson, D., Frampton, J., and García, P*. (2010). B-Myb is Critical for Proper DNA Duplication during an Unperturbed S phase in Mouse Embryonic Stem Cells. Stem Cells, 28: 1751-1759.
García, P*. Clarke, M.L., Vegiopoulos, A., Berlanga, O., Camelo, A., Lorvellec, M. and Frampton, J. (2009) Reduced c-Myb activity compromises HSCs and leads to a myeloproliferation with a novel stem cell basis. EMBO J, 28: 1492-1504.
García P., and Frampton, J. (2008) Hematopoietic lineage commitment: miRNAs add specificity to a widely expressed transcription factor. Dev Cell. 14: 815-6.
García, P., and Frampton J. (2006). The transcription factor B-Myb is a key regulator of DNA replication in both diploid and polyploidy megakaryocytes. J Cell Sci, 119: 1483-93.
Vegiopoulos, A., García, P., Emambokus, N. and Frampton, J. (2006) Coordination of erythropoiesis by the transcription factor c-Myb. Blood, 107: 4703-10.
García, P., Berlanga, O., Watson, R., and Frampton J. (2005) Generation of a conditional allele of the B-Myb gene. Genesis, 43: 189-95.
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