Spiliotopoulos A, Blokpoel Ferreras L, Densham RM, Caulton SG, Maddison BC, Morris JR, Dixon JE, Gough KC, Dreveny I. Discovery of peptide ligands targeting a specific ubiquitin-like domain-binding site in the deubiquitinase USP11. J Biol Chem. (2018) pii: jbc.RA118.004469. doi: 10.1074/jbc.RA118.004469.
Densham, RM, Garvin, AJ & Morris, JR.Ubiquitin, SUMO and the DNA double strand break response. In book: DNA Repair and Replication: Mechanisms and Clinical Significance Publisher: Garland Science; 1 edition (5 Sept. 2018) doi: 10.1201/9780429464744-9
Uckelmann M*, Densham RM*, Winterwerp HHK, Fish A, Sixma TK, Morris JR. USP48 restrains resection by site specific cleavage of the BRCA1 ubiquitin mark from H2A. Nature Communications (2018) 9:229 *joint first authors doi: 10.1038/s41467-017-02653-3
Densham RM, Morris JR. The BRCA1 Ubiquitin ligase function sets a new trend for remodelling in DNA repair. Nucleus. (2016) 29:1-10. doi: 10.1080/19491034.2016.1267092.
Densham RM, Garvin AJ, Stone HR, Strachan J, Baldock RA, Daza-Martin M, Fletcher A, Blair-Reid SA, Beesley J, Johal B, Pearl LH, Neely R, Keep NH, Watts FZ, Morris JR. Human BRCA1-BARD1 Ubiquitin ligase activity counters chromatin barriers to DNA resection. Nature Struc. Mol. Biol. (2016) 23 647-655 doi:10.1038/nsmb.3236
Garvin AJ, Densham RM, Blair-Reid SA, Pratt KM, Stone RM, Weekes D, Lawrence KJ, and Morris JR. The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair. EMBO reports (2013) 14(11) 975-83. doi: 10.1038/embor.2013.141.
Butler LR, Densham RM, Jia J, Garvin AJ, Stone HR, Shah V, Weekes D, Festy F, Beesley J, Morris JR. The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response. EMBO J. (2012) 31(19) 3918-34. doi: 10.1038/emboj.2012.232.
Morris JR, Boutell C, Keppler M, Densham R, Weekes D, Alamshah A, Butler L, Galanty Y, Pangon L, Kiuchi T, Ng T, Solomon E. The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress. Nature. (2009) 462 (7275) 886-90. doi: 10.1038/nature08593
Densham RM, O'Neill E, Munro J, König I, Anderson K, Kolch W, Olson MF. MST kinases monitor actin cytoskeletal integrity and signal via c-Jun N-terminal kinase stress-activated kinase to regulate p21Waf1/Cip1 stability. Mol Cell Biol. (2009) 29 (24) 6380-90. doi: 10.1128/MCB.00116-09
Densham RM, Todd DE, Balmanno K, Cook SJ. ERK1/2 and p38 cooperate to delay progression through G1 by promoting cyclin D1 protein turnover. Cell Signal. (2008) 20 (11) 1986-94. doi: 10.1016/j.cellsig.2008.07.005
Coleman ML, Densham RM, Croft DR, Olson MF. Stability of p21Waf1/Cip1 CDK inhibitor protein is responsive to RhoA-mediated regulation of the actin cytoskeleton. Oncogene. (2006) 252708-16.
Todd DE, Densham RM, Molton SM, Balmanno K, Newson C, Weston CR, Garner AP, Scott L, Cook SJ. ERK1/2 and p38 cooperate to induce a p21Cip1-dependent G1 cell cycle arrest. Oncogene (2004) 23 3284-3295
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