Services

Whole Slide Multiplex Tissue Analysis with Vectra Polaris System - YouTube

The Akoya PhenoImager™ HT system allows up to 9 colour multiplex immunofluoresence (mIF) and brightfield scanning. We have an existing set of pre-validated panels which require minimum optimisation according to specific tissues of interest. Additionally we can perform panel design and validation according to the needs of individual projects. Additionally, we can give access to Akoya Mantra 2.0 which acts as an optimisation platform for projects aimed for Polaris scanning and can be used to aid groups planning to stain for themselves but scan on the Polaris.

Key advantages:

Multi spectral imaging

Imaging on the PhenoImager HT can be applied across a whole slide using the 6-plex, 7 Color Opal Polaris reagent kit or up to 8-plex with deconvoluted region of interest scanning.

High throughput

Staining can be performed fully automated at scale using the Leica Bond RX autostainer platform.

Regulatory compliance

Highly reproducible staining can be applied across studies in line with Good clinical practice (GCP) in the laboratory standards as clinical trial outcome measure.

The Lunaphore COMET is our hyperplex immunofluorescence solution for researchers looking to explore cell-cell biology in greater detail. This system allows the visualisation of up to 40 markers in a tissue sample using the principle of sequential immunofluorescence approach. BTA can provide tissue staining use a range of pre-validated panels with an option to add additional markers of interest.

Key benefits

Deep immunophenotyping

Image up to 40 markers in a single tissue section in order to obtain greater insights into the spatial biology of tissue samples

Rapid panel design

Staining is compatible with pre-validated off-the-shelf, label-free antibodies.

Automation

End to end automation ensures high staining consistency between samples.

Spatial Biology Revealed with the GeoMx DSP by NanoString - YouTube

The BTA team is a Certified Service Provider for Nanostring GeoMx Protein and RNA.

The Nanostring GeoMx gives the capability for digital spatial profiling of regions of interest in FFPE sections. These can be profiled for either an 84 plex, 1800 plex or whole transcriptome analysis RNA panels, or a selection of configurable antibody panels made of ~10 plex modules up to ~60 plex.

nCounter Technology by NanoString - Direct Detection for Gene and Protein Expression Profiling - YouTube

The Nanostring nCounter can quantify up to 800 RNA targets without amplification from either extracted RNA including FFPE derived material using both off-the-shelf or custom panels available from Nanostring (including CE IVD marked clinical assays).