FRCPath Haemostasis and Thrombosis Training and Update (Online)Non-credit

Maintenance of blood fluidity and patency of the vascular system is crucial for normal human physiology. The term ‘haemostasis’ refers to the normal response of the vessel to injury by forming a clot that serves to limit haemorrhage. Thrombosis is pathological clot formation that results when haemostasis is excessively activated in the absence of bleeding. Under normal physiological conditions there is a delicate equilibrium between the pathological states of hypercoagulability and hypocoagulability in the circulating blood. Both inherited and acquired disorders can result in either bleeding or thrombosis.

Thrombosis may occur in veins (venous thrombosis) or in arteries (arterial thrombosis). Venous thrombosis leads to congestion of the affected part of the body, while arterial thrombosis affects the blood supply and leads to damage of the tissue supplied by that artery (ischaemia and necrosis). Fragments of either an arterial or a venous thrombus can also break off as an embolus which can travel through the circulation and cause thromboembolism. Accurate clinical and laboratory diagnosis of these disorders is therefore not only critical for the prevention of significant morbidity and mortality but improves patient care and quality of life through prevention and treatment of future bleeding and thrombotic events.

Our understanding of these physiological and pathophysiological conditions has also improved significantly over recent years. This has not only resulted in improved diagnosis but in the evolution of state of the art modern laboratory testing and therapies for both bleeding and thrombotic disorders. As the subject is also rapidly and continually evolving, this course aims to continually give up to date training from established clinicians and scientists in the field.

Learning outcomes:

• Understand the physiology and pathophysiology of all aspects of Haemostasis and Thrombosis
• Understand the clinical and laboratory diagnosis of inherited and acquired disorders of Haemostasis and Thrombosis
• Understand state of the art laboratory testing for diagnosing and monitoring treatment of Bleeding or Thrombotic Disorders
• Understand state of the art treatment strategies for either Bleeding or Thrombotic Disorders.

Accreditation:

The course is not accredited.

Course results:

Certificate of completion.

Programme teaching

• Up-to-date physiology and pathophysiology of Haemostasis and Thrombosis
• Comprehensive training in basic and advanced clinical and laboratory practice in Haemostasis and Thrombosis
• Interactive state of the art Lectures from established clinicians and scientists in the field
• FRCPath focussed
• 2 live sessions on Case based data interpretation
• 2 live Q&A sessions

Programme team:

• Alex Brill, University of Birmingham
• Tina Dutt, Royal Liverpool Hospital
• Keith Gomez, The Royal Free Hospital
• David Gurney, University Hospitals Birmingham
• Claire Harrison, Guy's and St Thomas'
• Paul Harrison, University of Birmingham
• Beverley Hunt, Guy's and St Thomas'
• Ian Jennings, Sheffield
• Steve Kitchen, Sheffield Teaching Hospitals
• Will Lester, University Hospitals Birmingham
• Gill Lowe, University Hospitals Birmingham
• Peter MacCallum, Royal London
• Gary Moore, Technoclone
• Neil Morgan, University of Birmingham
• Jayashree Motwani, Birmingham Women's and Children's Hospital
• Sue Pavord, University of Oxford
• Charles Percy, University Hospitals Birmingham
• Susie Shapiro, Oxford University Hospitals
• Mark Thomas, University of Birmingham
• Henry Watson, NHS Grampian
• Steve Watson, University of Birmingham

Dates of the course:

1st of February - 30th of April 2025

The live online zoom week dates:

• Wednesday 19th March at 17:30-19:00 GMT (Case Studies I)
• Tuesday 25th March at 17:30-19:00 GMT (Case Studies II)
• Wednesday 26th March at 17:30 - 19:00 GMT (Laboratory Testing Q&A)
• Thursday 27th March at 17:30-19:00 GMT (TTP and TMA's)
• Friday 28th March at 17:30-19:00 GMT (General Q&A session)

Course programme (to be confirmed):
Course content:
(Provisional)

Session 1

1 Course Overview and Welcome
Dr. Paul Harrison, University of Birmingham

2 Overview of Haemostasis
Dr. Paul Harrison, University of Birmingham

3 Laboratory Investigation of Coagulation Disorders
Dr. David Gurney, University Hospital Birmingham

4 Platelet Biochemistry & Function,
Professor Steve Watson, University of Birmingham

5 Paediatric Haemostasis & Rare Inherited Defects
Dr. Jayashree Motwani, Birmingham Children's Hospital

6 Modern Management of Haemophilia,
Dr Keith Gomez, Royal Free London NHSFT

Session 2

7 Anti-Platelet Drugs
Dr. Mark Thomas, University of Birmingham

8 Laboratory Control of Anticoagulants
Dr Steve Kitchen, Royal Hallamshire Hospital, Sheffield

9 Antiphospholipid Syndrome & Management,
Professor Beverley Hunt, Guy's and St Thomas' NHSFT

10 Neutrophil Extracellular Traps – a new paradigm in T&H
Dr Alex Brill, University of Birmingham

11 Thrombophilia & Duration of Anticoagulation
Dr Will Lester, University Hospital Birmingham

12 Acquired Risk Factors for Thrombosis I (Obesity, Malignancy, PNH, nephrotic syndrome) TBC

Session 3

13 Laboratory Diagnosis and Treatment of VWD
Dr Will Lester, University Hospital Birmingham

14 QC and EQA in Blood Coagulation
Dr Ian Jennings, Sheffield

15 Acquired Risk Factors for Thrombosis II (VTE Prophylaxis, HIT)
Dr Peter MacCallum, Royal Free London NHSFT

16 Myeloproliferative Diseases – Investigation/Management
Professor Claire Harrison, Guy's and St Thomas' NHSFT

17 Major Trauma and Haemostasis
Dr Paul Harrison, University of Birmingham

Session 4

18 Anticoagulants: New and Old
Dr Henry Watson, Aberdeen Royal Infirmary

19 Management of Acquired Bleeding Disorders
Dr Charles Percy, University Hospital Birmingham

20 Laboratory Data Interpretation
Dr David Gurney, University Hospital Birmingham

21 Thrombotic Microangiopathies - Laboratory Investigations & Treatment
Dr Tina Dutt, Royal Liverpool Hospital

22 Advances in genetic testing in Haemostasis
Dr Neil Morgan, University of Birmingham

Session 5

23 Antiphospholipid antibody assays
Dr Gary Moore, Technoclone

24 Lupus anticoagulant testing
Dr Gary Moore, Technoclone

25 ITP
Dr Sue Pavord, Oxford

26 Point of Care Testing & Treatment
Dr Dianne Kitchen, Sheffield

27 Thrombotic Disorders in Pregnancy
Dr Catherine Bagot, Glasgow

Programme subject to change.

This course is aimed at SpRs preparing for the part 2 FRCPath examination but is also suitable for clinicians, scientists and biomedical scientists in academia, the NHS, pharmaceutical and diagnostic companies wishing to gain intensive training in Haemostasis and Thrombosis.

£400 per person

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