In recent years, studies have suggested that the gastric microbiome may play a role in the development of cancer. However, these studies lacked data as to where the bacteria localise within the stomach.
Using the latest imaging technology to pinpoint the location of bacteria, scientists were able to see that while H. pylori exclusively colonised gastric glands, non-H. pylori bacteria leaked through the stomach lining in the pre-cancerous condition, gastric intestinal metaplasia. These findings suggest that bacterial leakage into deeper gastric tissues may represent a previously overlooked factor in cancer progression.
Researchers say the breakthrough may also explain why only a minority of H. pylori infections lead to gastric cancer and could pave the way for innovative diagnostic and therapeutic approaches.
Corresponding author of the paper Dr Amanda Rossiter-Pearson from the University of Birmingham said:
“We are excited about the potential of this observation to open a new avenue of research in the prevention of stomach cancer. It is possible that a simple antibiotic treatment could be administered to treat these bacteria. However, there is a lot more work to do.
“We must first determine the identity of these bacteria and understand how the presence of these bacteria in the precancerous condition impacts on the patient’s risk of developing stomach cancer.”
Dr Talisia Quallo, Research Programme Manager at Cancer Research UK, said:
“Stomach cancer has limited treatment options and poor survival rates. Better approaches are needed to find it earlier, and offer treatment when it is more likely to be successful.
“This research is showing us that the most common type of bacteria linked to stomach cancer, Helicobacter pylori, may work alongside other bacteria to drive a precursor condition to stomach cancer. Much more research is needed to understand how this interaction works, and what could be done to stop it, but from this research we can explore new ways to detect who will go on to develop stomach cancer."
