State-of-the-art facilities in Birmingham used to advance radiation therapy research

Researchers investigating how best to use alternative radiotherapies, potentially more effective with fewer side effects for some cancers, given funding boost.

Neutron accelerator.

University of Birmingham awarded funding to lead one of seven radiation research networks by Cancer Research UK.

Novel, quicker and more precise forms of radiotherapy will be tested at the University of Birmingham thanks to new funding from Cancer Research UK.

Professor Jason Parsons, who works across the School of Medical Sciences and the School of Physics and Astronomy, has been successful in leading a bid for Cancer Research UK RadNet funding to study proton beam therapy and other innovative types of radiotherapy. Professor Stuart Green from University Hospitals Birmingham NHS Foundation Trust will act as co-lead for RadNet Birmingham.

The RadNet Birmingham team will use pieces of highly specialised equipment, known as a cyclotron plus a neutron accelerator, to study innovative types and deliveries of radiotherapy. There are very few cyclotrons in the UK and Birmingham is unique in housing a neutron accelerator, both are dedicated to advance medical research compared to others that are in continual clinical use.

One of the areas that the team will investigate is boron neutron capture therapy, where radiotherapy can be given in a more precise way, meaning fewer side effects and more effective treatment. This is a promising avenue, but further research is needed to understand the underlying biology. Alongside this, the team will explore proton and helium ion therapy, to see if they can find safer but more biologically effective treatments for specific cancers.

Our unique facilities in medical physics put us at the forefront of radiation research and our interdisciplinary approach across the University will allow us to push boundaries.

Professor Jason Parsons

Professor Jason Parsons, Cancer and Genomic Sciences, School of Medical Sciences, University of Birmingham said:

“The new funding is a fantastic recognition of our innovative research in this area. Our unique facilities put us at the forefront of radiation research and our interdisciplinary approach across the University, including collaborations with leading physics and clinical teams plus support with other colleagues across the UK, is giving us access to the very best knowledge and resources to push boundaries in radiation research.

“The funding will allow us to build capacity and really capitalise on the facilities and expertise we have here in Birmingham.”

RadNet Birmingham will include clinical colleagues with expertise in head and neck cancer, brain cancer and paediatric oncology, all cancer types that are very reliant on radiotherapy. University of Birmingham has a strong research portfolio in each of these areas which will complement the work of the Team. They are also cancers where an urgent need has been recognised. For example, glioblastoma which is the most common form of brain cancer in adults, treatments have not changed in decades so any advances will be very welcome. Similarly, paediatric oncologists are calling for kinder treatments for children with cancer, so exploring options that are targeted with fewer side effects is vital.

The RadNet Centre in Birmingham launches this month, joining existing CRUK-funded centres that have been running since 2019. Together the centres create a portfolio of internationally leading research in radiation biology and radiation oncology. Each Centre will individually focus on separate aspects such as understanding of the underpinning biological mechanisms, as well as how best to apply and deliver radiotherapy, and are intended to work collaboratively throughout the funding period.

Dr Iain Foulkes, Executive Director of Research and Innovation at Cancer Research UK said:

“Cancer Research UK, and its predecessors, have been at the forefront of radiation research for the past 120 years. Thanks to research, radiotherapy treatment is becoming kinder, more precise and less intensive across different cancers.

“This funding marks a new phase of our RadNet network, advancing research which will further accelerate improvements in radiotherapy treatment in the clinic. This funding will work alongside our investments in pioneering radiotherapy clinical trials to ensure more people can live longer, better lives, free from the fear of cancer.”