Through the consultancy Apconix, a researcher at the University of Birmingham has been involved in a new project turning neuronal activity into music.
Tubular Cells
Through the consultancy Apconix, a researcher at the University of Birmingham has been involved in a new project turning neuronal activity into music.
Co-founded by Professor Ruth Roberts, Chair in Drug Discovery at the University of Birmingham, ApconiX has developed an in vitro seizure liability assay (iSLA) with 87% predictivity and excellent in vitro to in vivo translation. This assay helps identify potential seizurogenic compounds and assess the human relevance of seizures seen in vivo. The iSLA uses a panel of 15 human ion channels tested through automated electrophysiology and measures the electrical activity of human-derived neuronal stem cells using a microelectrode array (MEA).
In a new twist, scientists and musicians have turned these MEA electrical signals into music. Initially, brain cells plated on the MEA don’t communicate, but after 2-3 weeks, they form a network, sending electrical signals back and forth, much like the human brain.
The Story Behind Tubular Cells
At ApconiX, researchers record electrical signals from brain cells to study seizures. With help from programmers and musicians, these signals have been transformed into music. The brain cells, grown from human stem cells, are monitored in special plates with microelectrodes. Initially silent, the cells begin to communicate after a few weeks, creating a harmonious network. When drugs that induce seizures are added, the cells’ distress is audible, mimicking seizures and epilepsy. Remarkably, the cells recover once the drug is removed.
Creating Music from Brain Cells
Collaborators at Axion Biosystems recorded signals from the cells before, during, and after treatment with a seizure-inducing drug. Michael Sebastian, a musician, coded the electrical data to a synth chord voice, allowing the voices to open when neurons fired. He then added instruments and textures to create a beautiful piece of music.
This innovative approach not only advances our understanding of seizures but also beautifully illustrates the intersection of science and art
Tubular Cells is named after Mike Oldfield’s 1973 album, Tubular Bells. The music is copyrighted to Michael Sebastian, and the podcast was created by Paul Gisby of Talking Leaders.
Chair in Drug Discovery
Professor Ruth Roberts is Chair in Drug Discovery at the School of Biosciences and has an extensive career in drug discovery and development.
