Deficiency in PITX2 gene leads to less efficient mitochondria in heart cells of patients with Atrial Fibrillation
Patients with a common heart arrhythmia called Atrial Fibrillation could benefit from future treatments that target inefficiencies in heart cell metabolism, a new paper has found.
A study published in Cardiovascular Research Journal discovered that a gene deficiency found in patients with atrial fibrillation may be leading to reduced energy production in heart cells. Deficiencies in the PITX2 gene in heart cells leads to some mitochondria, which are parts of the cell that produce energy, being smaller and less efficient.
The team led by researchers from the Institute of Cardiovascular Sciences at the University of Birmingham and from University Medical Center Hamburg-Eppendorf in Germany studied lab-grown PITX2-deficient cardiac cells and compared to normal cardiac cells to study the effect of PITX2 on cell development and function.
This study shows how a specific gene affects the heart's ability to produce energy and maintain a regular rhythm, providing new insights into potential treatments for atrial fibrillation.
Professor Larissa Fabritz, Chair of Inherited Cardiac Conditions, University Center of Cardiovascular Science and Honorary Chair, Institute of Cardiovascular Sciences, University of Birmingham said:
“This study shows how a specific gene affects the heart's ability to produce energy and maintain a regular rhythm, providing new insights into potential treatments for atrial fibrillation.
“We observed that the deficiencies in the PITX2 gene leads to heart cells not functioning properly, including having a smaller and less efficient system for producing energy. This means that those heart cells are having to increasingly rely on glycolysis to produce energy which introduces oxygen stress into the mix.
“Normal cardiac metabolism uses free fatty acids as the primary energy source in resting conditions. It burns glucose when exerted as glucose metabolism is not dependent on oxygen, as opposed to fatty acid oxidation. In PITX2 deficiency, there is reduced mitochondrial respiration, pushing the heart cells into an oxygen-deficient stress state that uses glucose for energy. This shift is linked to increased spontaneous beating rates and irregularities in the heart cells' electrical activity.”
The findings could lead to new potential treatments for atrial fibrillation that target improving energy production in heart cells, particularly in those with PITX2-related deficiencies.
Honorary Professor
Professor Larissa Fabritz, Honorary Professor at the Department of Cardiovascular Sciences, University of Birmingham.
Honorary Professor
Staff profile of Professor Paulus Kirchhof, Honorary Professor at the Department of Cardiovascular Sciences, University of Birmingham
PhD Student
Staff profile for Laura Sommerfeld, PhD Student with the Heart Failure and Arrhythmia's Cluster, Institute of Cardiovascular Sciences.
