Study co-author Professor Alan McNally, from the University of Birmingham, commented: “CRAB poses a serious risk to hospitalised patients and can cause severe disease including pneumonia, urinary tract infection, bacteraemia, meningitis, and soft tissue infections – all of which can be very difficult to treat due to the bacteria’s multidrug-resistance.
“The quantity of CRAB found in this ICU highlights the urgent need for targeted infection prevention and control measures in healthcare facilities where such large accumulations of the bacteria are likely, so that we can stem the global spread of this pathogen.”
The study highlights the environment’s important role in CRAB persistence and eventual acquisition by patients. Researchers call for build-up of the bacteria to be tackled with infection prevention and control measures, including:
- Thorough and regular deep-cleaning of surfaces touched by patients and staff;
- Isolation of patients known to carry CRAB;
- Minimisation of patient relocation between beds; and
- Enhanced staff hand-washing protocols.
Researchers sampled the entire ICU, including staff, patients, and the environment, to reveal a remarkable diversity of CRAB in this setting - introduced to the unit as patients were admitted and driving the bacteria’s spread within the ICU.
CRAB can persist for prolonged periods on hospital surfaces and medical equipment, and colonise patients within 48 hours of admission - facilitated by hospital staff, shared equipment, airflow and plumbing. Outbreaks of CRAB can require interventions or changes to infrastructure that impose clinical, logistical, and financial burdens.
Antibiotic-resistant infections are a major threat to global public health. CRAB infections are found worldwide with severely limited treatment options prompting the World Health Organisation to designate CRAB a priority organism for which novel therapeutics are urgently required.
Professor McNally added: “In the absence of new therapeutic agents, effective CRAB IPC strategies are vital, if we are to limit the morbidity and mortality caused by the bacteria in hospitals. We must develop a thorough understanding of the persistence, transmission, and evolution of CRAB populations in such environments.”
