Reader in Metabolism and Inflammation joins the Institute of Inflammation and Ageing

Dr Claudio Mauro joins the Institute of Inflammation and Ageing at the University of Birmingham as a Reader in Metabolism and Inflammation. He has held a British Heart Foundation Fellowship for the past five years.

Dr Mauro will be deepening common research interests in the metabolic control of inflammation applied to major clinical challenges of our society, such as cardiovascular and autoimmune disease and ageing, which are major strengths of the research at the University of Birmingham.

Moving from Queen Mary University of London, Dr Mauro has spent the last seven years establishing himself as an emerging leading investigator in the field of immune-metabolism and metabolite-dependent regulation of the inflammatory response. He is applying these novel concepts to highly translational projects in the fields of cardiovascular and autoimmune disease.

Dr Mauro joins the University of Birmingham at an extremely exciting time following the recent investment of over £0.5 billion for the realisation of a brand new super-hospital, the Queen Elizabeth Hospital Birmingham, where translational research is at its heart.

“I am delighted to have joined the Institute of Inflammation and Ageing at the University of Birmingham. We are investigating how small metabolites, like lactate, which accumulates locally in the inflamed tissue or systemically during acute and chronic inflammation can impact the fate of the immune-inflammatory response via induction of  intracellular metabolic rewiring with immediate effect on broad range human diseases. We are also investigating how fatty acids can impact the outcomes of an immune response, with repercussions on obesity-related diseases." – Dr Claudio Mauro

His lab is based within the Queen Elizabeth Hospital Birmingham, in the multi-centre award winning Institute of Inflammation and Ageing, enabling fast track translation of novel biological discoveries, such as the one he recently led that a lactate/SLC5A12-induced-metabolic-signalling-network represents a key mediator of inflammation via modulation of CD4+ T-cell effector functions.

"The University of Birmingham hosts some of the best basic and translational science in UK in immunology and inflammatory diseases, with recent investments in people and infrastructures to become a national and international hub for high-throughput metabolic and metabolomics studies; the Phenome Centre and MTAC are just some examples. This is a great fit for me and my research, and I look forward to interact with colleagues and develop our studies here.” – Dr Claudio Mauro

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